PMID- 31026534
OWN - NLM
STAT- MEDLINE
DCOM- 20191223
LR  - 20191223
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 705
DP  - 2019 Jul 13
TI  - Levodopa imparts a normalizing effect on default-mode network connectivity in 
      non-demented Parkinson's disease.
PG  - 159-166
LID - S0304-3940(19)30284-8 [pii]
LID - 10.1016/j.neulet.2019.04.042 [doi]
AB  - INTRODUCTION: Parkinson's disease (PD) is characterized with reduced dopamine 
      level in the brain, resulting from the nigral degeneration. It is commonly 
      accepted that the function of default mode network (DMN) is disturbed in PD, even 
      in those who have no significant cognitive impairment. However, the relationship 
      between the depletion of dopamine and DMN dysconnectivity is not fully clear. The 
      aim of this study was to investigate the seed-based DMN connectivity and the 
      influence of dopaminergic therapy on the DMN integrity in non-demented PD by 
      using resting-state fMRI. MATERIAL AND METHODS: Resting-state fMRI data was 
      collected from 24 non-demented PD patients before and after taking levodopa and 
      36 healthy controls (HCs). Functional connectivity (FC) was examined by a 
      seed-based correlation approach. RESULTS: Compared with HCs, decreased DMN 
      connectivity in PD patients was observed, a number of which were significantly 
      improved after taking levodopa therapy. Moreover, by directly comparing the DMN 
      connectivity between ON- and OFF-medication conditions, we found significantly 
      enhanced FC in a set of regions of DMN in the ON- medication condition. 
      Conversely, we also found that the PCC revealed decreased FC with left inferior 
      temporal. CONCLUSION: DMN connectivity was found to be impaired in no-demented PD 
      patients, and levodopa has the ability to impart a normalizing effect on DMN 
      connectivity.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Zhong, Jianguo
AU  - Zhong J
AD  - Department of Radiology, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China; Department of Radiology, Zhejiang Provincial 
      People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, 
      China.
FAU - Guan, Xiaojun
AU  - Guan X
AD  - Department of Radiology, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Zhong, Xia
AU  - Zhong X
AD  - The First School of Medicine, Zhejiang Chinese Medical University, Hangzhou, 
      China.
FAU - Cao, Fang
AU  - Cao F
AD  - Department of Radiology, Zhejiang Provincial People's Hospital, People's Hospital 
      of Hangzhou Medical College, Hangzhou, China.
FAU - Gu, Quanquan
AU  - Gu Q
AD  - Department of Radiology, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Guo, Tao
AU  - Guo T
AD  - Department of Radiology, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Zhou, Cheng
AU  - Zhou C
AD  - Department of Radiology, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Zeng, Qiaoling
AU  - Zeng Q
AD  - Department of Radiology, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Wang, Jiaqiu
AU  - Wang J
AD  - Department of Neurology, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Gao, Ting
AU  - Gao T
AD  - Department of Neurology, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Zhang, Minming
AU  - Zhang M
AD  - Department of Radiology, the Second Affiliated Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China. Electronic address: zhangminming@zju.edu.cn.
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190423
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 46627O600J (Levodopa)
SB  - IM
MH  - Aged
MH  - Brain/*physiopathology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Levodopa/*therapeutic use
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/*physiopathology
MH  - Parkinson Disease/*drug therapy/*physiopathology
MH  - Rest
OTO - NOTNLM
OT  - Default mode network
OT  - Functional connectivity
OT  - Parkinson's disease
OT  - Resting-state functional MRI
EDAT- 2019/04/27 06:00
MHDA- 2019/12/24 06:00
CRDT- 2019/04/27 06:00
PHST- 2018/10/12 00:00 [received]
PHST- 2019/04/07 00:00 [revised]
PHST- 2019/04/20 00:00 [accepted]
PHST- 2019/04/27 06:00 [pubmed]
PHST- 2019/12/24 06:00 [medline]
PHST- 2019/04/27 06:00 [entrez]
AID - S0304-3940(19)30284-8 [pii]
AID - 10.1016/j.neulet.2019.04.042 [doi]
PST - ppublish
SO  - Neurosci Lett. 2019 Jul 13;705:159-166. doi: 10.1016/j.neulet.2019.04.042. Epub 
      2019 Apr 23.