PMID- 31027123
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20210112
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 17
DP  - 2019 Apr
TI  - A cohort study of age and sex specific risk of pyogenic liver abscess incidence 
      in patients with type 2 diabetes mellitus.
PG  - e15366
LID - 10.1097/MD.0000000000015366 [doi]
LID - e15366
AB  - To investigate the age-sex-specific incidence and relative risk of pyogenic liver 
      abscess (PLA) in patients with type 2 diabetes mellitus (T2DM), and to assess the 
      joint effects of T2DM and other clinical risk factors for PLA on PLA incidence. 
      We used a population-based cohort design with Taiwan's National Health Insurance 
      claim data. Study subjects included 613,921 T2DM patients and 614,613 controls 
      identified in 2000 and were followed to the end of 2010. Cox regression model was 
      employed to calculate the hazard ratio (HR) and 95% confidence interval (CI) of 
      PLA in relation to T2DM. Over an 11-year follow-up, 5336 T2DM and 1850 controls 
      were admitted for PLA, representing a cumulative incidence of 0.87% and 0.30%, 
      respectively. T2DM was significantly associated with increased hazard of PLA (HR, 
      2.88; 95% CI, 2.73-3.04). We also found that age and gender may significantly 
      modify the relationship between T2DM and PLA, with a higher HR noted in males 
      patients and those aged <45 years. Biliary tract diseases (HR, 8.60; 95% CI, 
      7.87-9.40) and liver cirrhosis (HR, 7.52; 95% CI, 6.58-8.59) may add 
      substantially additional risk to the incidence of PLA in T2DM patients. The 
      increased risk of PLA in T2DM was greater in male and younger patients. Careful 
      management of biliary tract diseases and liver cirrhosis may also help reduce the 
      incidence of PLA in T2DM patients.
FAU - Ko, Ming-Chung
AU  - Ko MC
AD  - Department of Urology, Taipei City Hospital.
AD  - Department of Health Care Management, National Taipei University of Nursing and 
      Health Sciences, Taipei.
FAU - Lin, Wei-Hung
AU  - Lin WH
AD  - Department of Internal Medicine, National Cheng Kung University Hospital, College 
      of Medicine, National Cheng Kung University, Tainan, Taiwan.
FAU - Martini, Santi
AU  - Martini S
AD  - Department of Epidemiology, Faculty of Public Health, Universitas Airlangga, 
      Surabaya, Indonesia.
FAU - Chang, Ya-Hui
AU  - Chang YH
AD  - Department of Public Health, College of Medicine, National Cheng Kung University.
FAU - Chiu, Chang-Ta
AU  - Chiu CT
AD  - Department of Dentistry, An Nan Hospital, China Medical University, Tainan.
FAU - Li, Chung-Yi
AU  - Li CY
AD  - Department of Epidemiology, Faculty of Public Health, Universitas Airlangga, 
      Surabaya, Indonesia.
AD  - Department of Public Health, College of Medicine, National Cheng Kung University.
AD  - Department of Public Health, College of Public Health, China Medical University, 
      Taichung, Taiwan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Biliary Tract Diseases/epidemiology
MH  - Cohort Studies
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Liver Abscess, Pyogenic/*epidemiology
MH  - Liver Cirrhosis/epidemiology
MH  - Male
MH  - Middle Aged
MH  - National Health Programs
MH  - Risk Factors
MH  - Sex Factors
MH  - Taiwan
PMC - PMC6831277
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2019/04/28 06:00
MHDA- 2019/05/21 06:00
PMCR- 2019/04/26
CRDT- 2019/04/28 06:00
PHST- 2019/04/28 06:00 [entrez]
PHST- 2019/04/28 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
PHST- 2019/04/26 00:00 [pmc-release]
AID - 00005792-201904260-00074 [pii]
AID - MD-D-18-07323 [pii]
AID - 10.1097/MD.0000000000015366 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Apr;98(17):e15366. doi: 10.1097/MD.0000000000015366.