PMID- 31027346
OWN - NLM
STAT- MEDLINE
DCOM- 20190819
LR  - 20200225
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 9
DP  - 2019 Apr 26
TI  - Regulation of Autophagy by Nuclear GAPDH and Its Aggregates in Cancer and 
      Neurodegenerative Disorders.
LID - 10.3390/ijms20092062 [doi]
LID - 2062
AB  - Several studies indicate that the cytosolic enzyme glyceraldehyde-3-phosphate 
      dehydrogenase (GAPDH) has pleiotropic functions independent of its canonical role 
      in glycolysis. The GAPDH functional diversity is mainly due to post-translational 
      modifications in different amino acid residues or due to protein-protein 
      interactions altering its localization from cytosol to nucleus, mitochondria or 
      extracellular microenvironment. Non-glycolytic functions of GAPDH include the 
      regulation of cell death, autophagy, DNA repair and RNA export, and they are 
      observed in physiological and pathological conditions as cancer and 
      neurodegenerative disorders. In disease, the knowledge of the mechanisms 
      regarding GAPDH-mediated cell death is becoming fundamental for the 
      identification of novel therapies. Here, we elucidate the correlation between 
      autophagy and GAPDH in cancer, describing the molecular mechanisms involved and 
      its impact in cancer development. Since autophagy is a degradative pathway 
      associated with the regulation of cell death, we discuss recent evidence 
      supporting GAPDH as a therapeutic target for autophagy regulation in cancer 
      therapy. Furthermore, we summarize the molecular mechanisms and the cellular 
      effects of GAPDH aggregates, which are correlated with mitochondrial malfunctions 
      and can be considered a potential therapeutic target for various diseases, 
      including cancer and neurodegenerative disorders.
FAU - Butera, Giovanna
AU  - Butera G
AD  - Department of Neurosciences, Biomedicine and Movement Sciences, Section of 
      Biochemistry, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy. 
      giovanna.butera@univr.it.
FAU - Mullappilly, Nidula
AU  - Mullappilly N
AD  - Department of Neurosciences, Biomedicine and Movement Sciences, Section of 
      Biochemistry, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy. 
      nidula.mullappilly@univr.it.
FAU - Masetto, Francesca
AU  - Masetto F
AD  - Department of Neurosciences, Biomedicine and Movement Sciences, Section of 
      Biochemistry, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy. 
      francesca.masetto@univr.it.
FAU - Palmieri, Marta
AU  - Palmieri M
AD  - Department of Neurosciences, Biomedicine and Movement Sciences, Section of 
      Biochemistry, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy. 
      marta.palmieri@univr.it.
FAU - Scupoli, Maria Teresa
AU  - Scupoli MT
AD  - Department of Neurosciences, Biomedicine and Movement Sciences, Section of 
      Biochemistry, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy. 
      mariateresa.scupoli@univr.it.
AD  - Research Center LURM (Interdepartmental Laboratory of Medical Research), 
      University of Verona, 37134 Verona, Italy. mariateresa.scupoli@univr.it.
FAU - Pacchiana, Raffaella
AU  - Pacchiana R
AD  - Department of Neurosciences, Biomedicine and Movement Sciences, Section of 
      Biochemistry, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy. 
      raffaella.pacchiana@univr.it.
FAU - Donadelli, Massimo
AU  - Donadelli M
AD  - Department of Neurosciences, Biomedicine and Movement Sciences, Section of 
      Biochemistry, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy. 
      massimo.donadelli@univr.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190426
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - EC 1.2.1.- (Glyceraldehyde-3-Phosphate Dehydrogenases)
MH  - Animals
MH  - Autophagy/*physiology
MH  - Glyceraldehyde-3-Phosphate Dehydrogenases/*metabolism
MH  - Humans
MH  - Models, Biological
MH  - Neoplasms/*metabolism
MH  - Neurodegenerative Diseases/*metabolism
PMC - PMC6539768
OTO - NOTNLM
OT  - GAPDH
OT  - aggregates
OT  - autophagy
OT  - cancer
OT  - cell death
COIS- The authors declare no conflicts of interest.
EDAT- 2019/04/28 06:00
MHDA- 2019/08/20 06:00
PMCR- 2019/05/01
CRDT- 2019/04/28 06:00
PHST- 2019/03/28 00:00 [received]
PHST- 2019/04/21 00:00 [revised]
PHST- 2019/04/23 00:00 [accepted]
PHST- 2019/04/28 06:00 [entrez]
PHST- 2019/04/28 06:00 [pubmed]
PHST- 2019/08/20 06:00 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - ijms20092062 [pii]
AID - ijms-20-02062 [pii]
AID - 10.3390/ijms20092062 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Apr 26;20(9):2062. doi: 10.3390/ijms20092062.