PMID- 31028655
OWN - NLM
STAT- MEDLINE
DCOM- 20200109
LR  - 20200309
IS  - 2092-9293 (Electronic)
IS  - 1976-9571 (Linking)
VI  - 41
IP  - 8
DP  - 2019 Aug
TI  - Correlation of constitutive photomorphogenic 1 (COP1) and p27 tumor suppressor 
      protein expression in ovarian cancer.
PG  - 879-884
LID - 10.1007/s13258-019-00818-6 [doi]
AB  - BACKGROUND: Constitutive photomorphogenic 1 (COP1) is an E3 ubiquitin ligase that 
      regulates important target proteins for cell growth including p27. The tumor 
      suppressor p27 negatively regulates the cell cycle by inhibiting cyclin-dependent 
      kinase. COP1 negatively regulates p27 stability by mediating its nuclear export 
      and degradation. OBJECTIVE: Even if COP1 and p27 are tightly related and have 
      significant roles in tumor progression, the expression patterns and relationship 
      of both proteins in cancer have not yet been studied. METHOD: We analyzed the 
      expression patterns and relationship between COP1 and p27 using an ovarian cancer 
      tissue microarray by dual immunofluorescence analysis. RESULTS: The expression 
      levels of COP1 and p27 proteins were not significantly different between ovarian 
      cancer tissue and normal control tissue. Other clinical data including age, tumor 
      type, tumor grade, and stage were not significantly related to expression of the 
      two proteins. The co-relationship between COP1 and p27 proteins was significantly 
      high (Pearson correlation coefficient 0.79, p = 8.65 x 10(-22)). CONCLUSIONS: Our 
      results demonstrate that while the expression levels of COP1 and p27 are highly 
      correlated, they are not significantly related to cancer progression in ovarian 
      cancer.
FAU - Ko, Eun-Ji
AU  - Ko EJ
AD  - Department of Parasitology and Genetics, Kosin University College of Medicine, 
      Busan, Republic of Korea.
AD  - Department of Biological Sciences, College of Natural Sciences, Pusan National 
      University, Busan, Republic of Korea.
FAU - Oh, Young Lim
AU  - Oh YL
AD  - Department of Obstetrics and Gynecology, Kosin University College of Medicine, 
      Busan, Republic of Korea.
FAU - Kim, Heung Yeol
AU  - Kim HY
AD  - Department of Obstetrics and Gynecology, Kosin University College of Medicine, 
      Busan, Republic of Korea.
FAU - Eo, Wan Kyu
AU  - Eo WK
AD  - Department of Internal Medicine, Kyung Hee University, Seoul, Republic of Korea.
FAU - Kim, Hongbae
AU  - Kim H
AD  - Department of Obstetrics and Gynecology, Hallym University College of Medicine, 
      Chuncheon, Republic of Korea.
FAU - Kim, Ki Hyung
AU  - Kim KH
AD  - Department of Obstetrics and Gynecology, Pusan National University School of 
      Medicine, Busan, Republic of Korea.
AD  - Biomedical Research Institute and Pusan Cancer Center, Pusan National University 
      Hospital, Busan, Republic of Korea.
FAU - Koh, Suk Bong
AU  - Koh SB
AD  - Department of Obstetrics and Gynecology, School of Medicine, Catholic University 
      of Daegu, Daegu, Republic of Korea.
FAU - Ock, Mee Sun
AU  - Ock MS
AD  - Department of Parasitology and Genetics, Kosin University College of Medicine, 
      Busan, Republic of Korea.
FAU - Choi, Yung Hyun
AU  - Choi YH
AD  - Department of Biochemistry, College of Oriental Medicine, Dongeui University, 
      Busan, Republic of Korea.
FAU - Kim, Ari
AU  - Kim A
AD  - Department of Obstetrics and Gynecology, Chicago Medical School, Rosalind 
      Franklin University of Medicine and Science, Vernon Hills, IL, USA.
FAU - Choi, Hyun Ho
AU  - Choi HH
AD  - Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The 
      Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
AD  - Research Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun 
      Yat-sen University, Guangzhou, China.
FAU - Park, Eun Joo
AU  - Park EJ
AD  - Department of Obstetrics and Gynecology, Eulji Medical Center, Eulji University, 
      Seoul, Republic of Korea. pej3119@eulji.ac.kr.
FAU - Cha, Hee-Jae
AU  - Cha HJ
AUID- ORCID: 0000-0002-6963-2685
AD  - Department of Parasitology and Genetics, Kosin University College of Medicine, 
      Busan, Republic of Korea. hcha@kosin.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20190426
PL  - Korea (South)
TA  - Genes Genomics
JT  - Genes & genomics
JID - 101481027
RN  - 147604-94-2 (Cyclin-Dependent Kinase Inhibitor p27)
RN  - EC 2.3.2.27 (COP1 protein, human)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
MH  - Cyclin-Dependent Kinase Inhibitor p27/*genetics/metabolism
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Ovarian Neoplasms/genetics/*metabolism
MH  - Ubiquitin-Protein Ligases/*genetics/metabolism
OTO - NOTNLM
OT  - COP1
OT  - Expression
OT  - Ovarian cancer
OT  - Tissue microarray
OT  - p27
EDAT- 2019/04/28 06:00
MHDA- 2020/01/10 06:00
CRDT- 2019/04/28 06:00
PHST- 2019/01/23 00:00 [received]
PHST- 2019/04/02 00:00 [accepted]
PHST- 2019/04/28 06:00 [pubmed]
PHST- 2020/01/10 06:00 [medline]
PHST- 2019/04/28 06:00 [entrez]
AID - 10.1007/s13258-019-00818-6 [pii]
AID - 10.1007/s13258-019-00818-6 [doi]
PST - ppublish
SO  - Genes Genomics. 2019 Aug;41(8):879-884. doi: 10.1007/s13258-019-00818-6. Epub 
      2019 Apr 26.