PMID- 31028817
OWN - NLM
STAT- MEDLINE
DCOM- 20200312
LR  - 20200312
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 86
DP  - 2019 Jun
TI  - Parental perinatal exposure to bisphenol A reduces the threshold to disrupt 
      blastocyst implantation via decreasing talin, occudin and E-cadherin levels.
PG  - 86-97
LID - S0890-6238(19)30071-1 [pii]
LID - 10.1016/j.reprotox.2019.04.005 [doi]
AB  - The aim was to evaluate the effect of perinatal BPA exposure of one or both 
      parents on the implantation index and expression of talin, occludin and 
      E-cadherin in the uterine epithelial cells (UEC) of the offspring. Pregnant 
      Wistar dams (F0) received BPA or vehicle from gestational day (GD) 6 to lactation 
      day 21. F1 animals were mated forming four groups: Control dam-Control sire 
      (Cfemale symbol-Cmale symbol), BPA dam -Control sire (Bfemale symbol-Cmale symbol), Control dam -BPA sire (Cfemale symbol-Bmale symbol), BPA dam 
      -BPA sire (Bfemale symbol-Bmale symbol). F1 dams were sacrificed at GD 6. Significantly decreased 
      number of implantation sites was observed in the Bfemale symbol-Bmale symbol group as compared to the 
      Cfemale symbol-Cmale symbol group, which correlated with decreased talin apical/basal expression ratio, 
      occludin apical expression, and E-cadherin apical/lateral expression ratio in the 
      UEC. Furthermore, decreased E-cadherin expression in the blastocyst was observed. 
      Our data suggest that reduced protein expressions in F1 BPA offspring could 
      result from decreased progesterone serum levels.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Martinez-Pena, Annia A
AU  - Martinez-Pena AA
AD  - Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de 
      Mexico, Ciudad de Mexico 04510, Mexico.
FAU - Pena-Castillo, Andrea
AU  - Pena-Castillo A
AD  - Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de 
      Mexico, Ciudad de Mexico 04510, Mexico.
FAU - Parra-Forero, L Yuliana
AU  - Parra-Forero LY
AD  - Departamento de Toxicologia, Centro de Investigacion y de Estudios Avanzados del 
      Instituto Politecnico Nacional (Cinvestav), Ciudad de Mexico 07360, Mexico.
FAU - Hernandez-Ochoa, Isabel
AU  - Hernandez-Ochoa I
AD  - Departamento de Toxicologia, Centro de Investigacion y de Estudios Avanzados del 
      Instituto Politecnico Nacional (Cinvestav), Ciudad de Mexico 07360, Mexico.
FAU - Hernandez-Barrientos, Luis R
AU  - Hernandez-Barrientos LR
AD  - Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de 
      Mexico, Ciudad de Mexico 04510, Mexico.
FAU - Morimoto, Sumiko
AU  - Morimoto S
AD  - Instituto Nacional de Ciencias Medicas y de la Nutricion Salvador Zubiran, Ciudad 
      de Mexico 14080, Mexico.
FAU - Mendoza-Rodriguez, C Adriana
AU  - Mendoza-Rodriguez CA
AD  - Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de 
      Mexico, Ciudad de Mexico 04510, Mexico. Electronic address: adrimed@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190424
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (CDH1 protein, rat)
RN  - 0 (Cadherins)
RN  - 0 (Occludin)
RN  - 0 (Ocln protein, rat)
RN  - 0 (Phenols)
RN  - 0 (Talin)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Benzhydryl Compounds/*toxicity
MH  - Cadherins/*metabolism
MH  - Embryo Implantation/*drug effects
MH  - Estradiol/blood
MH  - Female
MH  - Male
MH  - *Maternal-Fetal Exchange
MH  - Occludin/*metabolism
MH  - Phenols/*toxicity
MH  - Pregnancy
MH  - Progesterone/blood
MH  - Rats, Wistar
MH  - Talin/*metabolism
MH  - Uterus/drug effects/metabolism
OTO - NOTNLM
OT  - Bisphenol-A
OT  - Blastocyst
OT  - E-cadherin
OT  - Implantation
OT  - Occluding
OT  - Talin
OT  - Uterus
EDAT- 2019/04/28 06:00
MHDA- 2020/03/13 06:00
CRDT- 2019/04/28 06:00
PHST- 2019/02/20 00:00 [received]
PHST- 2019/04/06 00:00 [revised]
PHST- 2019/04/22 00:00 [accepted]
PHST- 2019/04/28 06:00 [pubmed]
PHST- 2020/03/13 06:00 [medline]
PHST- 2019/04/28 06:00 [entrez]
AID - S0890-6238(19)30071-1 [pii]
AID - 10.1016/j.reprotox.2019.04.005 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2019 Jun;86:86-97. doi: 10.1016/j.reprotox.2019.04.005. Epub 2019 
      Apr 24.