PMID- 31028857
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20200106
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 239
DP  - 2019 Jul 15
TI  - Chrysanthemum indicum extract inhibits NLRP3 and AIM2 inflammasome activation via 
      regulating ASC phosphorylation.
PG  - 111917
LID - S0378-8741(19)30342-3 [pii]
LID - 10.1016/j.jep.2019.111917 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Chrysanthemum indicum (C. indicum), a perennial 
      plant, has long been used to treat inflammation-related disorders, such as 
      pneumonia, hypertension, gastritis, and gastroenteritis. AIM OF THE STUDY: The 
      inhibitory effect of C. indicum extract (C.I) on inflammasome activation was 
      investigated to validate its potential in treating inflammation related 
      disorders. MATERIALS AND METHODS: LPS-primed bone marrow-derived macrophages 
      (BMDMs) were used to confirm the inhibitory effect of C.I on selective 
      inflammasome activation in vitro. A monosodium urate (MSU)-induced murine 
      peritonitis model was employed to study the effect of C.I in vivo. RESULTS: C.I 
      inhibited activation of NLRP3 and AIM2 inflammasomes, leading to suppression of 
      interleukin-1beta secretion in vitro. Further, C.I regulates the phosphorylation of 
      apoptosis-associated speck-like protein containing a CARD (ASC), which could be 
      the main contribution to attenuate these inflammasomes activation. C.I also 
      suppressed secretion of pro-inflammatory cytokines and neutrophils recruitment in 
      MSU-induced murine peritonitis model. CONCLUSIONS: This study provides scientific 
      evidence substantiating the traditional use of C. indicum in the treatment of 
      inflammatory diseases, including gout, which is induced by physiologically 
      analogous cause to MSU-induced peritonitis.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Yu, Sang-Hyeun
AU  - Yu SH
AD  - Department of Applied Life Science, Graduate School, BK21 Plus Glocal Education 
      Program of Neutraceuticals Development, Konkuk University, Chungju, South Korea.
FAU - Sun, Xiao
AU  - Sun X
AD  - Department of Applied Life Science, Graduate School, BK21 Plus Glocal Education 
      Program of Neutraceuticals Development, Konkuk University, Chungju, South Korea.
FAU - Kim, Myong-Ki
AU  - Kim MK
AD  - Department of Food Science and Engineering, Seowon University, Cheongju, South 
      Korea.
FAU - Akther, Mahbuba
AU  - Akther M
AD  - Department of Applied Life Science, Graduate School, BK21 Plus Glocal Education 
      Program of Neutraceuticals Development, Konkuk University, Chungju, South Korea.
FAU - Han, Jun-Hyuk
AU  - Han JH
AD  - Department of Applied Life Science, Graduate School, BK21 Plus Glocal Education 
      Program of Neutraceuticals Development, Konkuk University, Chungju, South Korea.
FAU - Kim, Tae-Yeon
AU  - Kim TY
AD  - Department of Applied Life Science, Graduate School, BK21 Plus Glocal Education 
      Program of Neutraceuticals Development, Konkuk University, Chungju, South Korea.
FAU - Jiang, Jun
AU  - Jiang J
AD  - Key Laboratory of Natural Resource of Changbai Mountain and Functional Molecules 
      (Ministry of Education), College of Agriculture, Yanbian University, Yanji, 
      Jilin, China.
FAU - Kang, Tae-Bong
AU  - Kang TB
AD  - Department of Biotechnology, College of Biomedical & Health Science, Research 
      Institute of Inflammatory Diseases, Konkuk University, Chungju, South Korea.
FAU - Lee, Kwang-Ho
AU  - Lee KH
AD  - Department of Applied Life Science, Graduate School, BK21 Plus Glocal Education 
      Program of Neutraceuticals Development, Konkuk University, Chungju, South Korea; 
      Department of Biotechnology, College of Biomedical & Health Science, Research 
      Institute of Inflammatory Diseases, Konkuk University, Chungju, South Korea. 
      Electronic address: kwangho@kku.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20190425
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Aim2 protein, mouse)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (CARD Signaling Adaptor Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Gout Suppressants)
RN  - 0 (Inflammasomes)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Nlrp3 protein, mouse)
RN  - 0 (Plant Extracts)
RN  - 0 (Pycard protein, mouse)
RN  - 268B43MJ25 (Uric Acid)
RN  - EC 2.7.12.2 (MAP Kinase Kinase 4)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology/therapeutic use
MH  - CARD Signaling Adaptor Proteins/*metabolism
MH  - *Chrysanthemum
MH  - DNA-Binding Proteins/*metabolism
MH  - Female
MH  - Gout/drug therapy/metabolism
MH  - Gout Suppressants/pharmacology/therapeutic use
MH  - Inflammasomes/*metabolism
MH  - MAP Kinase Kinase 4/metabolism
MH  - Mice, Inbred C57BL
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/*metabolism
MH  - Peritonitis/chemically induced/drug therapy/*metabolism
MH  - Phosphorylation/drug effects
MH  - Plant Components, Aerial
MH  - Plant Extracts/*pharmacology/therapeutic use
MH  - Uric Acid
OTO - NOTNLM
OT  - ASC phosphorylation
OT  - Chrysanthemum indicum
OT  - Inflammasome
OT  - MSU-Induced peritonitis
OT  - NLRP3
EDAT- 2019/04/28 06:00
MHDA- 2020/01/07 06:00
CRDT- 2019/04/28 06:00
PHST- 2019/01/24 00:00 [received]
PHST- 2019/04/22 00:00 [revised]
PHST- 2019/04/23 00:00 [accepted]
PHST- 2019/04/28 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2019/04/28 06:00 [entrez]
AID - S0378-8741(19)30342-3 [pii]
AID - 10.1016/j.jep.2019.111917 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2019 Jul 15;239:111917. doi: 10.1016/j.jep.2019.111917. Epub 
      2019 Apr 25.