PMID- 31028920
OWN - NLM
STAT- MEDLINE
DCOM- 20200210
LR  - 20200210
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 197
DP  - 2019 Aug 15
TI  - Enhanced high-frequency precuneus-cortical effective connectivity is associated 
      with decreased sensory gating following total sleep deprivation.
PG  - 255-263
LID - S1053-8119(19)30343-X [pii]
LID - 10.1016/j.neuroimage.2019.04.057 [doi]
AB  - Sleep deprivation decreases an individual's cognitive function. When cognitive 
      impairment reaches a certain level, human errors occur and may even result in 
      accidents. Previous research has shown that sensory gating is a basic mechanism 
      in cognitive function, but only limited studies have so far reported how it is 
      affected by sleep deprivation. This study aimed to analyze the effects of sleep 
      deprivation on sensory gating and its cognitive and neural mechanisms. Thirty-six 
      healthy subjects participated in our study. The resting-state, auditory P50-task 
      electroencephalography (EEG) recordings and the psychomotor vigilance task (PVT) 
      were performed at resting wakefulness (RW) and after 36 h of total sleep 
      deprivation (TSD). Changes in P50 suppression before and after sleep deprivation 
      were recorded, and the isolated effective coherence (iCoh) was employed for 
      analyzing effective connectivity based on EEG data during the resting-state and 
      P50 tasks. Subjects demonstrated reduced P50 suppression and prolonged PVT 
      reaction time after TSD compared with RW. Effective connectivity analysis of 
      resting-state EEG data showed that sleep deprivation decreased the connectivity 
      from the right middle occipital gyrus (RMOG)/Rcuneus to left inferior/middle 
      temporal gyrus (LITG/LMTG) and left parahippocampal/fusiform gyrus (LPH/LFG). EEG 
      data analysis during the P50 task showed that, in addition to the aforementioned 
      connectivity changes, the directed high-frequency effective connectivity from the 
      left precuneus to the left superior/middle frontal gyrus (LSFG/LMFG), LITG/LMTG, 
      LPH/LFG, and left middle occipital gyrus (LMOG)/Lcuneus increased. P50 
      suppression in Cz positively correlated with PVT reaction time. This study 
      reveals that the precuneus is a key brain region in neural network correlates of 
      sensory gating, and that changes in its effective connectivity with other regions 
      (including LSFG/LMFG, LPH/LFG, LMOG/LCuneus, and LITG/LMTG) are important for 
      decreasing sensory gating after TSD.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Zhang, Liwei
AU  - Zhang L
AD  - Department of Psychology, Beijing Sport University, Beijing, 100084, China; 
      School of Biological Science and Medical Engineering, Beihang University, 
      Beijing, 100083, China; Beijing Advanced Innovation Centre for Biomedical 
      Engineering, Beihang University, Beijing, 102402, China.
FAU - Huang, Yue
AU  - Huang Y
AD  - Department of Medical Psychology, Army Medical University, Chongqing, 400038, 
      China.
FAU - Zhang, Ying
AU  - Zhang Y
AD  - The Eighth Medical Center, The General Hospital of the People's Liberation Army, 
      Beijing, 100091, China.
FAU - Xin, Wei
AU  - Xin W
AD  - The Sixth Medical Center, The General Hospital of the People's Liberation Army, 
      Beijing, 100048, China.
FAU - Shao, Yongcong
AU  - Shao Y
AD  - Department of Psychology, Beijing Sport University, Beijing, 100084, China. 
      Electronic address: budeshao@aliyun.com.
FAU - Yang, Yebing
AU  - Yang Y
AD  - The Sixth Medical Center, The General Hospital of the People's Liberation Army, 
      Beijing, 100048, China. Electronic address: yangyebing2005@aliyun.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190425
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Cerebral Cortex/*physiopathology
MH  - Electroencephalography
MH  - Evoked Potentials, Auditory
MH  - Female
MH  - Humans
MH  - Male
MH  - Neural Pathways/physiopathology
MH  - Parietal Lobe/*physiopathology
MH  - Psychomotor Performance
MH  - Reaction Time
MH  - Sensory Gating/*physiology
MH  - Sleep Deprivation/*physiopathology
MH  - Young Adult
OTO - NOTNLM
OT  - Effective connectivity
OT  - Electroencephalogram
OT  - Sensory gating function
OT  - Sleep deprivation
EDAT- 2019/04/28 06:00
MHDA- 2020/02/11 06:00
CRDT- 2019/04/28 06:00
PHST- 2019/01/16 00:00 [received]
PHST- 2019/04/13 00:00 [revised]
PHST- 2019/04/20 00:00 [accepted]
PHST- 2019/04/28 06:00 [pubmed]
PHST- 2020/02/11 06:00 [medline]
PHST- 2019/04/28 06:00 [entrez]
AID - S1053-8119(19)30343-X [pii]
AID - 10.1016/j.neuroimage.2019.04.057 [doi]
PST - ppublish
SO  - Neuroimage. 2019 Aug 15;197:255-263. doi: 10.1016/j.neuroimage.2019.04.057. Epub 
      2019 Apr 25.