PMID- 31029883
OWN - NLM
STAT- MEDLINE
DCOM- 20200720
LR  - 20200720
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 401
DP  - 2019 Jun 15
TI  - Clinical correlates of repetitive speech disorders in Parkinson's disease.
PG  - 67-71
LID - S0022-510X(19)30169-8 [pii]
LID - 10.1016/j.jns.2019.04.012 [doi]
AB  - OBJECTIVES: This study aimed to explore clinical correlates of repetitive speech 
      disorders in patients with Parkinson's disease (PD). METHODS: This study 
      investigated speech function (Assessment of Motor Speech for Dysarthria and 
      Stuttering Severity Instrument-3), motor function (Unified Parkinson's Disease 
      Rating Scale III [UPDRS-III] and UPDRS-IV), cognitive function (Mini-Mental State 
      Examination [MMSE], Montreal Cognitive Assessment [MoCA], Stroop color-word test, 
      verbal fluency, digit span tests, and line orientation), and activities of daily 
      living of 113 PD patients. Comparison between groups (independent t-tests, 
      Mann-Whitney U tests, or chi(2) test) and linear regression analyses were performed 
      to determine clinical correlates of repetitive speech disorders. RESULTS: 
      Totally, 65 patients (57.5%) had repetitive speech disorders. Patients with 
      repetitive speech disorders had significantly worse UPDRS-III (P = .049), MoCA 
      (P = .030), and speech function and higher levodopa equivalent daily dose (LEDD; 
      P = .031) than those without repetitive speech disorders. Males were 
      significantly predominant in patients with repetitive speech disorders (64.6%) 
      compared to those without repetitive speech disorders (18.7%; P < .001). The 
      univariate and subsequent multiple linear regression analyses revealed that the 
      severity of repetitive speech disorders significantly correlated with gender 
      (P < .001), MoCA (P = .006), and speech variables (abnormal rate, P = .007; 
      imprecise consonants, P = .043), independent from disease duration, UPDRS III, 
      and LEDD. CONCLUSIONS: PD patients with repetitive speech disorders had worse 
      motor, cognitive, and speech functions than those without repetitive speech 
      disorders. The most influential factor for repetitive speech disorders might be 
      male gender.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Tsuboi, Takashi
AU  - Tsuboi T
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Watanabe, Hirohisa
AU  - Watanabe H
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan; Brain and Mind Research Center, Nagoya University, Nagoya, Japan. 
      Electronic address: nabe@med.nagoya-u.ac.jp.
FAU - Tanaka, Yasuhiro
AU  - Tanaka Y
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Ohdake, Reiko
AU  - Ohdake R
AD  - Brain and Mind Research Center, Nagoya University, Nagoya, Japan.
FAU - Sato, Maki
AU  - Sato M
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Hattori, Makoto
AU  - Hattori M
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Kawabata, Kazuya
AU  - Kawabata K
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Hara, Kazuhiro
AU  - Hara K
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Nakatsubo, Daisuke
AU  - Nakatsubo D
AD  - Department of Neurosurgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Maesawa, Satoshi
AU  - Maesawa S
AD  - Department of Neurosurgery, Nagoya University Graduate School of Medicine, 
      Nagoya, Japan.
FAU - Kajita, Yasukazu
AU  - Kajita Y
AD  - Department of Neurosurgery, National Hospital Organization Nagoya Medical Center, 
      Nagoya, Japan.
FAU - Katsuno, Masahisa
AU  - Katsuno M
AD  - Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, 
      Japan.
FAU - Sobue, Gen
AU  - Sobue G
AD  - Brain and Mind Research Center, Nagoya University, Nagoya, Japan. Electronic 
      address: sobueg@med.nagoya-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20190411
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Antiparkinson Agents)
RN  - 46627O600J (Levodopa)
SB  - IM
MH  - Activities of Daily Living
MH  - Aged
MH  - Antiparkinson Agents/administration & dosage/therapeutic use
MH  - Cognition
MH  - Dyskinesias/etiology/physiopathology
MH  - Female
MH  - Humans
MH  - Levodopa/administration & dosage/therapeutic use
MH  - Male
MH  - Memory
MH  - Mental Status and Dementia Tests
MH  - Middle Aged
MH  - Parkinson Disease/*complications/*psychology
MH  - Sex Factors
MH  - Speech Disorders/*etiology/*psychology
MH  - Speech Production Measurement
MH  - Stroop Test
MH  - Verbal Behavior
OTO - NOTNLM
OT  - Cognitive dysfunction
OT  - Gender
OT  - Parkinson's disease
OT  - Repetitive speech disorders
EDAT- 2019/04/29 06:00
MHDA- 2020/07/21 06:00
CRDT- 2019/04/29 06:00
PHST- 2018/06/22 00:00 [received]
PHST- 2019/04/01 00:00 [revised]
PHST- 2019/04/09 00:00 [accepted]
PHST- 2019/04/29 06:00 [pubmed]
PHST- 2020/07/21 06:00 [medline]
PHST- 2019/04/29 06:00 [entrez]
AID - S0022-510X(19)30169-8 [pii]
AID - 10.1016/j.jns.2019.04.012 [doi]
PST - ppublish
SO  - J Neurol Sci. 2019 Jun 15;401:67-71. doi: 10.1016/j.jns.2019.04.012. Epub 2019 
      Apr 11.