PMID- 31031497
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 0259-1162 (Print)
IS  - 2229-7685 (Electronic)
IS  - 2229-7685 (Linking)
VI  - 13
IP  - 1
DP  - 2019 Jan-Mar
TI  - Comparison of Heparin Quick Penetrating Solution and Diclofenac Quick Penetrating 
      Solution for the Prevention of Superficial Thrombophlebitis Caused by Peripheral 
      Venous Cannulation: A Randomized Double-Blind Study.
PG  - 155-157
LID - 10.4103/aer.AER_189_18 [doi]
AB  - BACKGROUND AND AIMS: The association of superficial thrombophlebitis (ST) with 
      deep-venous thrombosis varies between 6% and 44%. Thus, prevention of ST is 
      important. The aim of this study was to compare the efficacy of topical quick 
      penetrating solution (QPS) of heparin 1000 IU/mL versus diclofenac QPS for 
      prevention of postinfusion ST. SETTINGS AND DESIGN: This is a randomized, 
      controlled, double-blind study. MATERIALS AND METHODS: The study was done after 
      ethical clearance and Clinical Trial Registry- India registration to compare 100 
      patients for the prevention of ST with application of heparin QPS and diclofenac 
      QPS at regular intervals. Patients were randomized into two groups (Group H 
      [control group] - heparin QPS group and Group D - diclofenac QPS group) and the 
      assigned treatment was applied four times daily. The appearance of 
      thrombophlebitis was graded on the basis of infusion nursing society scale. The 
      site of venous cannulation was inspected every 6 h for any changes for the next 5 
      days. STATISTICAL ANALYSIS: The parametric data were analyzed using Student's 
      t-test and nonparametric data were analyzed by Kruskal-Wallis test. RESULTS: Of 
      98, only 10 patients developed thrombophlebitis and all belonged to Group D 
      (23%). No patient belonging to Group H developed thrombophlebitis (0%). This 
      difference was statistically significant (P = 0.034). CONCLUSION: The QPS 
      formulation of heparine and diclofenac was effective in preventing 
      thrombophlebitis. Heparine QPS is more effective than diclofenac QPS for the 
      same.
FAU - Akhileshwar
AU  - Akhileshwar
AD  - Department of Anaesthesiology, Indira Gandhi Institute of Medical Sciences, 
      Patna, Bihar, India.
FAU - Singh, Swati
AU  - Singh S
AD  - Department of Anaesthesiology, Indira Gandhi Institute of Medical Sciences, 
      Patna, Bihar, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Anesth Essays Res
JT  - Anesthesia, essays and researches
JID - 101578762
PMC - PMC6444970
OTO - NOTNLM
OT  - Diclofenac
OT  - heparin
OT  - thrombophlebitis
OT  - vein
COIS- There are no conflicts of interest.
EDAT- 2019/04/30 06:00
MHDA- 2019/04/30 06:01
PMCR- 2019/01/01
CRDT- 2019/04/30 06:00
PHST- 2019/04/30 06:00 [entrez]
PHST- 2019/04/30 06:00 [pubmed]
PHST- 2019/04/30 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - AER-13-155 [pii]
AID - 10.4103/aer.AER_189_18 [doi]
PST - ppublish
SO  - Anesth Essays Res. 2019 Jan-Mar;13(1):155-157. doi: 10.4103/aer.AER_189_18.