PMID- 31031709
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200225
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 10
DP  - 2019
TI  - Plasma Low-Density Lipoprotein Cholesterol Correlates With Heart Function in 
      Individuals With Type 2 Diabetes Mellitus: A Cross-Sectional Study.
PG  - 234
LID - 10.3389/fendo.2019.00234 [doi]
LID - 234
AB  - Background: Heart failure is a frequent complication of type 2 diabetes mellitus 
      (T2DM). Plasma cholesterol, particularly the proatherogenic low-density 
      lipoprotein (LDL) cholesterol, impairs heart function by promoting atheroma 
      formation and ventricular dysfunction. Considering the established effect of 
      cholesterol on the cardiovascular system, we hypothesized that plasma LDL 
      cholesterol may influence left ventricular function in individuals with T2DM. 
      Methods: This cross-sectional study was conducted at a tertiary care hospital in 
      Taiwan. Enrollment criteria were patients exceeding 21 years of age with T2DM who 
      received antidiabetic and cholesterol-lowering medications. Candidates were 
      excluded if they had heart failure, acute cardiovascular events, or familial 
      hypercholesterolemia. Participants received blood sampling for plasma lipids 
      after a 12-h fast, followed by transthoracic echocardiography in the cardiology 
      clinic. Results: The study enrolled 118 participants who were divided into two 
      groups according to their plasma LDL cholesterol levels. Demographic 
      characteristics including age (69.7 vs. 66.9 years, P = 0.159), body mass index 
      (26.2 vs. 25.9 kg/m(2), P = 0.66), diabetes duration (5.4 vs. 5.1 years, P = 
      0.48), hemoglobin A(1c) (7.2 vs. 7.5%, P = 0.225), and systolic blood pressure 
      (129 vs. 130 mm Hg, P = 0.735) were similar between these groups. Moreover, all 
      participants received similar antihypertensive medications. Participants with 
      lower plasma LDL cholesterol levels had better heart function, as measured by the 
      left ventricular ejection fraction (LVEF), than patients with higher LDL 
      cholesterol levels (58.0 vs. 50.5%, P = 0.022). Multivariate regression analysis 
      also showed an inverse correlation between plasma LDL cholesterol and left 
      ventricular function (beta coefficient: -0.110, P = 0.024). Conclusion: This study 
      observed an inverse correlation between plasma LDL cholesterol and heart function 
      in individuals with T2DM. Patients with higher levels of plasma LDL cholesterol 
      had worse left ventricular function. Therefore, plasma LDL cholesterol may be a 
      modifiable risk factor of heart failure in diabetes, but prospective studies are 
      necessary to confirm this finding.
FAU - Cheng, Po-Chung
AU  - Cheng PC
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Changhua Christian Hospital, Changhua, Taiwan.
FAU - Hsu, Shang-Ren
AU  - Hsu SR
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Changhua Christian Hospital, Changhua, Taiwan.
FAU - Li, Jung-Chi
AU  - Li JC
AD  - Division of Cardiology, Department of Internal Medicine, Changhua Christian 
      Hospital, Changhua, Taiwan.
FAU - Chen, Ching-Pei
AU  - Chen CP
AD  - Division of Cardiology, Department of Internal Medicine, Changhua Christian 
      Hospital, Changhua, Taiwan.
FAU - Chien, Szu-Chi
AU  - Chien SC
AD  - Division of Cardiology, Department of Internal Medicine, Changhua Christian 
      Hospital, Changhua, Taiwan.
FAU - Tu, Shih-Te
AU  - Tu ST
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Changhua Christian Hospital, Changhua, Taiwan.
FAU - Cheng, Yun-Chung
AU  - Cheng YC
AD  - Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan.
FAU - Liu, Yu-Hsiu
AU  - Liu YH
AD  - Department of Accounting and Information Systems, National Taichung University of 
      Science and Technology, Taichung, Taiwan.
FAU - Kuo, Jeng-Fu
AU  - Kuo JF
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Changhua Christian Hospital, Changhua, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20190411
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC6470411
OTO - NOTNLM
OT  - heart failure
OT  - heart function
OT  - hyperlipidemia
OT  - left ventricular ejection fraction
OT  - low-density lipoprotein cholesterol
OT  - type 2 diabetes mellitus
EDAT- 2019/04/30 06:00
MHDA- 2019/04/30 06:01
PMCR- 2019/01/01
CRDT- 2019/04/30 06:00
PHST- 2018/12/30 00:00 [received]
PHST- 2019/03/25 00:00 [accepted]
PHST- 2019/04/30 06:00 [entrez]
PHST- 2019/04/30 06:00 [pubmed]
PHST- 2019/04/30 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2019.00234 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2019 Apr 11;10:234. doi: 10.3389/fendo.2019.00234. 
      eCollection 2019.