PMID- 31032197
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2223-4292 (Print)
IS  - 2223-4306 (Electronic)
IS  - 2223-4306 (Linking)
VI  - 9
IP  - 3
DP  - 2019 Mar
TI  - Functional endoscopy techniques for tracking stem cell fate.
PG  - 510-520
LID - 10.21037/qims.2019.02.12 [doi]
AB  - Tracking and monitoring implanted stem cells are essential to maximize benefits 
      and to minimize the side effects of stem cell therapy for personalized or 
      "precision" medicine. Previously, we proposed a comprehensive biological Global 
      Positioning System (bGPS) to track and monitor stem cells in vivo. Magnetic 
      resonance imaging (MRI), positron emission tomography (PET), bioluminescent 
      imaging, fluorescence imaging, and single-photon emission computerized tomography 
      (SPECT) have been utilized to track labeled or genetically-modified cells in vivo 
      in rats and humans. A large amount of research has been dedicated to the design 
      of reporter genes and molecular probes for imaging and the visualization of the 
      biodistribution of the implanted cells in high resolution. On the other hand, 
      optical-based functional imaging, such as photoacoustic imaging (PAI), optical 
      coherence tomography (OCT), and multiphoton microscopy (MPM), has been 
      implemented into small endoscopes to image cells inside the body. The optical 
      fiber allows miniaturization of the imaging probe while maintaining high 
      resolution due to light-based imaging. Upon summarizing the recent progress in 
      the design and application of functional endoscopy techniques for stem cell 
      monitoring, we offer perspectives for the future development of endoscopic 
      molecular imaging tools for in vivo tracking of spatiotemporal changes in 
      subclonal evolution at the single cell level.
FAU - Miao, Yusi
AU  - Miao Y
AD  - Beckman Laser Institute, University of California Irvine, Irvine, CA, USA.
FAU - Chen, Zhongping
AU  - Chen Z
AD  - Beckman Laser Institute, University of California Irvine, Irvine, CA, USA.
FAU - Li, Shengwen Calvin
AU  - Li SC
AD  - Department of Neurology, University of California Irvine School of Medicine, 
      Orange, CA, USA.
AD  - Department of Biological Science, California State University, Fullerton, CA, 
      USA.
AD  - CHOC Children's Research Institute, Children's Hospital of Orange County (CHOC), 
      University of California Irvine, Orange, CA, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - Quant Imaging Med Surg
JT  - Quantitative imaging in medicine and surgery
JID - 101577942
PMC - PMC6462564
OTO - NOTNLM
OT  - Endoscopy
OT  - biological GPS
OT  - cell tracking
OT  - stem cell research
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2019/04/30 06:00
MHDA- 2019/04/30 06:01
PMCR- 2019/03/01
CRDT- 2019/04/30 06:00
PHST- 2019/04/30 06:00 [entrez]
PHST- 2019/04/30 06:00 [pubmed]
PHST- 2019/04/30 06:01 [medline]
PHST- 2019/03/01 00:00 [pmc-release]
AID - qims-09-03-510 [pii]
AID - 10.21037/qims.2019.02.12 [doi]
PST - ppublish
SO  - Quant Imaging Med Surg. 2019 Mar;9(3):510-520. doi: 10.21037/qims.2019.02.12.