PMID- 31033198
OWN - NLM
STAT- MEDLINE
DCOM- 20201002
LR  - 20201002
IS  - 2151-4658 (Electronic)
IS  - 2151-464X (Linking)
VI  - 72
IP  - 7
DP  - 2020 Jul
TI  - Comparison of the Birmingham Vasculitis Activity Score and the Five-Factor Score 
      to Assess Survival in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: 
      A Study of 550 Patients From Spain (REVAS Registry).
PG  - 1001-1010
LID - 10.1002/acr.23912 [doi]
AB  - OBJECTIVE: To compare the accuracy of the Birmingham Vasculitis Activity Score 
      (BVAS), version 3, and the Five Factor Score (FFS), version 1996 and version 
      2009, to assess survival in antineutrophil cytoplasmic antibody-associated 
      vasculitis (AAV). METHODS: A total of 550 patients with AAV (41.1% with 
      granulomatosis with polyangiitis, 37.3% with microscopic polyangiitis, and 21.6% 
      with eosinophilic granulomatosis with polyangiitis), diagnosed between 1990 and 
      2016, were analyzed. Receiver operating characteristic (ROC) curves and 
      multivariable Cox analysis were used to assess the relationships between the 
      outcome and the different scores. RESULTS: Overall mortality was 33.1%. The mean 
      +/- SD BVAS at diagnosis was 17.96 +/- 7.82 and was significantly higher in 
      nonsurvivors than in survivors (mean +/- SD 20.0 +/- 8.14 versus 16.95 +/- 7.47, 
      respectively; P < 0.001). The mean +/- SD 1996 FFS and 2009 FFS were 0.81 +/- 0.94 
      and 1.47 +/- 1.16, respectively, and were significantly higher in nonsurvivors than 
      in survivors (mean +/- SD 1996 FFS 1.17 +/- 1.07 versus 0.63 +/- 0.81 [P < 0.001] and 
      2009 FFS 2.13 +/- 1.09 versus 1.15 +/- 1.05 [P < 0.001], respectively). Mortality 
      rates increased according to the different 1996 FFS and 2009 FFS categories. In 
      multivariate analysis, BVAS, 1996 FFS, and 2009 FFS were significantly related to 
      death (P = 0.007, P = 0.020, P < 0.001, respectively), but the stronger predictor 
      was the 2009 FFS (hazard ratio 2.9 [95% confidence interval 2.4-3.6]). When the 
      accuracy of BVAS, 1996 FFS, and 2009 FFS to predict survival was compared in the 
      global cohort, ROC analysis yielded area under the curve values of 0.60, 0.65, 
      and 0.74, respectively, indicating that 2009 FFS had the best performance. 
      Similar results were obtained when comparing these scores in patients diagnosed 
      before and after 2001 and when assessing the 1-year, 5-year, and long-term 
      mortality. Correlation among BVAS and 1996 FFS was modest (r = 0.49; P < 0.001) 
      but higher than between BVAS and the 2009 FFS (r = 0.28; P < 0.001). CONCLUSION: 
      BVAS and FFS are useful to predict survival in AAV, but the 2009 FFS has the best 
      prognostic accuracy at any point of the disease course.
CI  - (c) 2019, American College of Rheumatology.
FAU - Solans-Laque, Roser
AU  - Solans-Laque R
AUID- ORCID: 0000-0002-0058-1293
AD  - Hospital Valle Hebron, Barcelona, Spain.
FAU - Rodriguez-Carballeira, Monica
AU  - Rodriguez-Carballeira M
AD  - Mutua Terrassa, Barcelona, Spain.
FAU - Rios-Blanco, Juan Jose
AU  - Rios-Blanco JJ
AD  - Hospital La Paz, Madrid, Spain.
FAU - Fraile, Guadalupe
AU  - Fraile G
AD  - Hospital Ramon y Cajal, Madrid, Spain.
FAU - Saez-Comet, Luis
AU  - Saez-Comet L
AD  - Hospital Miguel Servet, Zaragoza, Spain.
FAU - Martinez-Zapico, Aleida
AU  - Martinez-Zapico A
AD  - Hospital Central de Asturias, Asturias, Spain.
FAU - Frutos, Begona
AU  - Frutos B
AD  - Hospital Fuenlabrada, Madrid, Spain.
FAU - Solanich, Xavier
AU  - Solanich X
AD  - Hospital Bellvitge, Barcelona, Spain.
FAU - Fonseca-Aizpuru, Eva
AU  - Fonseca-Aizpuru E
AD  - Hospital Cabuenes, Asturias, Spain.
FAU - Pasquau-Liano, Francisco
AU  - Pasquau-Liano F
AD  - Hospital Marina Baixa, Villajoyosa, Alicante, Spain.
FAU - Zamora, Monica
AU  - Zamora M
AD  - Hospital Virgen de las Nieves, Granada, Spain.
FAU - Oristrell, Joaquim
AU  - Oristrell J
AD  - Hospital Parc Tauli, Sabadell, Barcelona, Spain.
FAU - Fanlo, Patricia
AU  - Fanlo P
AD  - Hospital Clinica de Navarra, Spain.
FAU - Lopez-Dupla, Miguel
AU  - Lopez-Dupla M
AD  - Hospital Joan XXIII, Tarragona, Spain.
FAU - Abdilla, Monica
AU  - Abdilla M
AD  - Hospital La Ribera, Alzira, Valencia, Spain.
FAU - Garcia-Sanchez, Isabel
AU  - Garcia-Sanchez I
AD  - Hospital Infanta Leonor, Madrid, Spain.
FAU - Sopena, Bernardo
AU  - Sopena B
AD  - Centro Hospitalario de Vigo, Vigo, Spain.
FAU - Castillo, Maria Jesus
AU  - Castillo MJ
AD  - Hospital Virgen del Rocio, Seville, Spain.
FAU - Perales, Isabel
AU  - Perales I
AD  - Hospital Rey Juan Carlos, Madrid, Spain.
FAU - Callejas, Jose Luis
AU  - Callejas JL
AD  - Hospital San Cecilio, Granada, Spain.
CN  - Spanish Registry of Systemic Vasculitis, the Autoimmune Systemic Diseases Study 
      Group, and the Spanish Society of Internal Medicine
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20200612
PL  - United States
TA  - Arthritis Care Res (Hoboken)
JT  - Arthritis care & research
JID - 101518086
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*mortality
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Registries
MH  - *Severity of Illness Index
MH  - Spain
MH  - Young Adult
EDAT- 2019/04/30 06:00
MHDA- 2020/10/03 06:00
CRDT- 2019/04/30 06:00
PHST- 2018/08/05 00:00 [received]
PHST- 2019/04/23 00:00 [accepted]
PHST- 2019/04/30 06:00 [pubmed]
PHST- 2020/10/03 06:00 [medline]
PHST- 2019/04/30 06:00 [entrez]
AID - 10.1002/acr.23912 [doi]
PST - ppublish
SO  - Arthritis Care Res (Hoboken). 2020 Jul;72(7):1001-1010. doi: 10.1002/acr.23912. 
      Epub 2020 Jun 12.