PMID- 31033214 OWN - NLM STAT- MEDLINE DCOM- 20200826 LR - 20200826 IS - 1613-6829 (Electronic) IS - 1613-6810 (Linking) VI - 15 IP - 24 DP - 2019 Jun TI - Mesoporous Silica-Based Materials with Bactericidal Properties. PG - e1900669 LID - 10.1002/smll.201900669 [doi] AB - Bacterial infections are the main cause of chronic infections and even mortality. In fact, due to extensive use of antibiotics and, then, emergence of antibiotic resistance, treatment of such infections by conventional antibiotics has become a major concern worldwide. One of the promising strategies to treat infection diseases is the use of nanomaterials. Among them, mesoporous silica materials (MSMs) have attracted burgeoning attention due to high surface area, tunable pore/particle size, and easy surface functionalization. This review discusses how one can exploit capacities of MSMs to design and fabricate multifunctional/controllable drug delivery systems (DDSs) to combat bacterial infections. At first, the emergency of bacterial and biofilm resistance toward conventional antimicrobials is described and then how nanoparticles exert their toxic effects upon pathogenic cells is discussed. Next, the main aspects of MSMs (e.g., physicochemical properties, multifunctionality, and biosafety) which one should consider in the design of MSM-based DDSs against bacterial infections are introduced. Finally, a comprehensive analysis of all the papers published dealing with the use of MSMs for delivery of antibacterial chemicals (antimicrobial agents functionalized/adsorbed on mesoporous silica (MS), MS-loaded with antimicrobial agents, gated MS-loaded with antimicrobial agents, MS with metal-based nanoparticles, and MS-loaded with metal ions) is provided. CI - (c) 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. FAU - Bernardos, Andrea AU - Bernardos A AD - Instituto Interuniversitario de Investigacion de Reconocimiento Molecular y Desarrollo Tecnologico (IDM), Universitat Politecnica de Valencia, Universitat de Valencia. Cami de Vera s/n, 46022, Valencia, Spain. AD - CIBER de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), Unidad Mixta UPV-CIPF de Investigacion en Mecanismos de Enfermedades y Nanomedicina, Valencia, Universitat Politecnica de Valencia, Centro de Investigacion Principe Felipe, 46012, Valencia, Spain. FAU - Piacenza, Elena AU - Piacenza E AD - Faculty of Science, Department of Biological Sciences, University of Calgary, Calgary, AB, Canada. FAU - Sancenon, Felix AU - Sancenon F AD - Instituto Interuniversitario de Investigacion de Reconocimiento Molecular y Desarrollo Tecnologico (IDM), Universitat Politecnica de Valencia, Universitat de Valencia. Cami de Vera s/n, 46022, Valencia, Spain. AD - CIBER de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), Unidad Mixta UPV-CIPF de Investigacion en Mecanismos de Enfermedades y Nanomedicina, Valencia, Universitat Politecnica de Valencia, Centro de Investigacion Principe Felipe, 46012, Valencia, Spain. AD - Departamento de Quimica, Universitat Politecnica de Valencia, Cami de Vera s/n, 46022, Valencia, Spain. AD - Unidad Mixta de Investigacion en Nanomedicina y Sensores, Universitat Politecnica de Valencia, Instituto de Investigacion Sanitaria La Fe, 46026, Valencia, Spain. FAU - Hamidi, Mehrdad AU - Hamidi M AD - Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, 45139-56184, Zanjan, Iran. FAU - Maleki, Aziz AU - Maleki A AD - Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, 45139-56184, Zanjan, Iran. FAU - Turner, Raymond J AU - Turner RJ AD - Faculty of Science, Department of Biological Sciences, University of Calgary, Calgary, AB, Canada. FAU - Martinez-Manez, Ramon AU - Martinez-Manez R AUID- ORCID: 0000-0001-5873-9674 AD - Instituto Interuniversitario de Investigacion de Reconocimiento Molecular y Desarrollo Tecnologico (IDM), Universitat Politecnica de Valencia, Universitat de Valencia. Cami de Vera s/n, 46022, Valencia, Spain. AD - CIBER de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), Unidad Mixta UPV-CIPF de Investigacion en Mecanismos de Enfermedades y Nanomedicina, Valencia, Universitat Politecnica de Valencia, Centro de Investigacion Principe Felipe, 46012, Valencia, Spain. AD - Departamento de Quimica, Universitat Politecnica de Valencia, Cami de Vera s/n, 46022, Valencia, Spain. AD - Unidad Mixta de Investigacion en Nanomedicina y Sensores, Universitat Politecnica de Valencia, Instituto de Investigacion Sanitaria La Fe, 46026, Valencia, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20190429 PL - Germany TA - Small JT - Small (Weinheim an der Bergstrasse, Germany) JID - 101235338 RN - 0 (Anti-Bacterial Agents) RN - 0 (Biocompatible Materials) RN - 0 (Drug Carriers) RN - 7631-86-9 (Silicon Dioxide) SB - IM MH - Anti-Bacterial Agents/chemistry/*pharmacology MH - Bacteria/drug effects/growth & development MH - Bacterial Physiological Phenomena/drug effects MH - Biocompatible Materials/chemistry/*pharmacology MH - Biofilms/drug effects MH - Drug Carriers/chemistry/pharmacology MH - Drug Delivery Systems MH - Humans MH - Microbial Sensitivity Tests MH - Nanostructures/*chemistry/therapeutic use MH - Porosity MH - Silicon Dioxide/*chemistry/pharmacology OTO - NOTNLM OT - antibiotics OT - controllable drug delivery systems OT - mesoporous silica materials OT - nanoparticles EDAT- 2019/04/30 06:00 MHDA- 2020/08/28 06:00 CRDT- 2019/04/30 06:00 PHST- 2019/02/05 00:00 [received] PHST- 2019/03/25 00:00 [revised] PHST- 2019/04/30 06:00 [pubmed] PHST- 2020/08/28 06:00 [medline] PHST- 2019/04/30 06:00 [entrez] AID - 10.1002/smll.201900669 [doi] PST - ppublish SO - Small. 2019 Jun;15(24):e1900669. doi: 10.1002/smll.201900669. Epub 2019 Apr 29.