PMID- 31035539
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 8
IP  - 5
DP  - 2019 Apr 27
TI  - Preoperative Health-Related Quality of Life Predicts Minimal Clinically Important 
      Difference and Survival after Surgical Resection of Hepatocellular Carcinoma.
LID - 10.3390/jcm8050576 [doi]
LID - 576
AB  - Despite the growing use of minimal clinically important difference (MCID) as a 
      cancer outcome measure, no study has reported clinically significant outcomes in 
      cancer patients. We defined MCID and evaluated the use of preoperative HRQoL for 
      predicting MCID and survival after surgical resection of hepatocellular carcinoma 
      (HCC). In total, 369 patients completed the Functional Assessment of Cancer 
      Therapy-Hepatobiliary (FACT-Hep) and the SF-36 at baseline and at two years 
      post-operative at three tertiary academic hospitals. The corresponding MCID 
      values were 3.6 (SF-36 physical component summary), 4.2 (SF-36 mental component 
      summary), 5.4 (FACT-General total score), and 6.7 (FACT-Hep total score). The 
      predictors of achieving postoperative MCID were significantly higher in patients 
      who had low preoperative HRQoL score, advanced age, high education level, and 
      high BMI (p < 0.05). However, patients with a high preoperative HRQoL score, high 
      education level, high BMI, and low Charlson comorbidity index score were 
      significantly associated with survival (p < 0.05). Preoperative HRQoL scores were 
      predictive of MCID and overall survival after surgical resection of HCC. The 
      findings of this study may be useful for managing the preoperative expectations 
      of candidates for HCC resection and for developing shared decision-making 
      procedures for patients undergoing surgical resection of HCC.
FAU - Chiu, Chong-Chi
AU  - Chiu CC
AUID- ORCID: 0000-0002-1696-2648
AD  - Department of General Surgery, Chi Mei Medical Center, Liouying 73657, Taiwan. 
      sdp0127@gmail.com.
AD  - Department of General Surgery, Chi Mei Medical Center, Tainan 71004, Taiwan. 
      sdp0127@gmail.com.
AD  - Department of Electrical Engineering, Southern Taiwan University of Science and 
      Technology, Tainan 71005, Taiwan. sdp0127@gmail.com.
FAU - Lee, King-Teh
AU  - Lee KT
AD  - Division of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical 
      University Hospital, Kaohsiung 80708, Taiwan. ktlee@kmu.edu.tw.
AD  - Department of Healthcare Administration and Medical Informatics, Kaohsiung 
      Medical University, Kaohsiung 80708, Taiwan. ktlee@kmu.edu.tw.
FAU - Wang, Jhi-Joung
AU  - Wang JJ
AD  - Department of Medical Research, Chi Mei Medical Center, Tainan 71004, Taiwan. 
      400002@mail.chimei.org.tw.
FAU - Sun, Ding-Ping
AU  - Sun DP
AD  - Department of General Surgery, Chi Mei Medical Center, Tainan 71004, Taiwan. 
      sdp0127@gmail.com.
FAU - Lee, Hao-Hsien
AU  - Lee HH
AD  - Department of General Surgery, Chi Mei Medical Center, Liouying 73657, Taiwan. 
      hao_hsien@hotmail.com.
FAU - Huang, Chien-Cheng
AU  - Huang CC
AD  - Department of Emergency Medicine, Chi Mei Medical Center, Tainan 71004, Taiwan. 
      honyi6165@yahoo.com.
AD  - Department of Senior Services, Southern Taiwan University of Science and 
      Technology, Tainan 71005, Taiwan. honyi6165@yahoo.com.
FAU - Shi, Hon-Yi
AU  - Shi HY
AD  - Department of Healthcare Administration and Medical Informatics, Kaohsiung 
      Medical University, Kaohsiung 80708, Taiwan. hshi@kmu.edu.tw.
AD  - Department of Business Management, National Sun Yat-sen University, Kaohsiung 
      80424, Taiwan. hshi@kmu.edu.tw.
AD  - Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 
      80708, Taiwan. hshi@kmu.edu.tw.
LA  - eng
GR  - CLFHR 10301 & 10409/The Chi Mei Medical Center, Liouying, Research Grant/
GR  - 107CM-KMU/The Chi-Mei Medical Center and the Kaohsiung Medical University 
      Research Foundation/
PT  - Journal Article
DEP - 20190427
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC6572462
OTO - NOTNLM
OT  - health-related quality of life
OT  - hepatocellular carcinoma
OT  - minimal clinically important difference
OT  - survival
COIS- There authors declare no conflict of interest.
EDAT- 2019/05/01 06:00
MHDA- 2019/05/01 06:01
PMCR- 2019/04/27
CRDT- 2019/05/01 06:00
PHST- 2019/02/23 00:00 [received]
PHST- 2019/04/13 00:00 [revised]
PHST- 2019/04/22 00:00 [accepted]
PHST- 2019/05/01 06:00 [entrez]
PHST- 2019/05/01 06:00 [pubmed]
PHST- 2019/05/01 06:01 [medline]
PHST- 2019/04/27 00:00 [pmc-release]
AID - jcm8050576 [pii]
AID - jcm-08-00576 [pii]
AID - 10.3390/jcm8050576 [doi]
PST - epublish
SO  - J Clin Med. 2019 Apr 27;8(5):576. doi: 10.3390/jcm8050576.