PMID- 31035928
OWN - NLM
STAT- MEDLINE
DCOM- 20200128
LR  - 20221207
IS  - 1471-2318 (Electronic)
IS  - 1471-2318 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Apr 29
TI  - Prevalence of and factors associated with sarcopenia among multi-ethnic 
      ambulatory older Asians with type 2 diabetes mellitus in a primary care setting.
PG  - 122
LID - 10.1186/s12877-019-1137-8 [doi]
LID - 122
AB  - BACKGROUND: Sarcopenia is the age-related loss of muscle mass and function, which 
      increases fall risks in older persons. Hyperglycemia relating to Type-2 Diabetes 
      Mellitus (T2DM) is postulated to aggravate sarcopenia. This study aimed to 
      determine the prevalence of sarcopenia among ambulatory community-dwelling older 
      patients, aged 60-89 years, with T2DM in a primary care setting and to identify 
      factors which mitigate sarcopenia. METHODS: A total of 387 patients were 
      recruited from a public primary care clinic in Singapore. Data on their 
      socio-demography, clinical and functional status, levels of physical activity 
      (International Physical Activity Questionnaire) and frailty status was collected. 
      The Asian Working Group for Sarcopenia (AWGS) criteria were used to define 
      sarcopenia based on muscle mass, grip strength and gait speed. RESULTS: The study 
      population comprised men (53%), Chinese (69%), mean age = 68.3 +/- SD5.66 years, 
      lived in public housing (90%), had hypertension (88%) and dyslipidemia (96%). 
      Their mean muscle mass was 6.3 +/- SD1.2 kg/m(2); mean gait speed was 
      1.0 +/- SD0.2 m/s and mean grip strength was 25.5 +/- SD8.1 kg. Overall, 30% had 
      pre-sarcopenia, 24% with sarcopenia and 4% with severe sarcopenia. Age 
      (OR = 1.14; 95%CI = 1.09-1.20;p < 0.001), multi-morbidity 
      (OR = 1.25;95%CI = 1.05-1.49;p = 0.011) diabetic nephropathy 
      (OR = 2.50;95%CI = 1.35-5.13;p = 0.004), hip circumference 
      (OR = 0.86;95%CI = 0.82-0.90;p < 0.001) and number of clinic visits in past 1 
      year (OR = 0.74; 95%CI = 0.59-0.92;p = 0.008) were associated with sarcopenia. 
      CONCLUSIONS: Using AWGS criteria, 58% of older patients with T2DM had 
      pre-sarcopenia and sarcopenia. Age, diabetic nephropathy, hip circumference, 
      multi-morbidity and fewer clinic visits, but not a recent single HBA1c reading, 
      were significantly associated with sarcopenia among patients with T2DM. A 
      longitudinal relationship between clinic visits and sarcopenia should be further 
      evaluated. (250 words).
FAU - Fung, Foon Yin
AU  - Fung FY
AUID- ORCID: 0000-0002-6414-9301
AD  - Duke NUS Medical School, 8 College Road, Singapore, 169857, Singapore. 
      fung.foon.yin@u.duke.nus.edu.
FAU - Koh, Yi Ling Eileen
AU  - Koh YLE
AD  - SingHealth Polyclinics, 167 Jalan Bukit Merah Connection One Tower 5 #15-10, 
      Singapore, 150167, Singapore.
FAU - Malhotra, Rahul
AU  - Malhotra R
AD  - Duke NUS Medical School, 8 College Road, Singapore, 169857, Singapore.
FAU - Ostbye, Truls
AU  - Ostbye T
AD  - Duke NUS Medical School, 8 College Road, Singapore, 169857, Singapore.
FAU - Lee, Ping Yein
AU  - Lee PY
AD  - Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, 
      Serdang, Selangor Darul Ehsan, Malaysia.
FAU - Shariff Ghazali, Sazlina
AU  - Shariff Ghazali S
AD  - Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, 
      Serdang, Selangor Darul Ehsan, Malaysia.
FAU - Tan, Ngiap Chuan
AU  - Tan NC
AD  - Duke NUS Medical School, 8 College Road, Singapore, 169857, Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190429
PL  - England
TA  - BMC Geriatr
JT  - BMC geriatrics
JID - 100968548
SB  - IM
RPI - BMC Geriatr. 2020 Oct 20;20(1):415. PMID: 33081718
CIN - BMC Geriatr. 2021 Dec 11;21(1):690. PMID: 34895174
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/*ethnology
MH  - Diabetes Mellitus, Type 2/diagnosis/*ethnology/therapy
MH  - Exercise/physiology
MH  - Female
MH  - Frailty/diagnosis/ethnology/therapy
MH  - Hand Strength/physiology
MH  - Humans
MH  - *Independent Living/trends
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Primary Health Care/*methods
MH  - Sarcopenia/diagnosis/*ethnology/therapy
MH  - Singapore/epidemiology
PMC - PMC6489356
OTO - NOTNLM
OT  - Aging
OT  - Diabetes
OT  - Hip circumference
OT  - Sarcopenia
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: This study was reviewed and approved 
      by the SingHealth Centralized Institutional Review Board (CIRB reference 
      2017/2393). Participants were provided the approved patient information sheet, 
      clarified on their queries and recruited after the investigator obtained their 
      informed written consent. CONSENT FOR PUBLICATION: Not applicable. COMPETING 
      INTERESTS: The authors declare that they have no competing interests. PUBLISHER'S 
      NOTE: Springer Nature remains neutral with regard to jurisdictional claims in 
      published maps and institutional affiliations.
EDAT- 2019/05/01 06:00
MHDA- 2020/01/29 06:00
PMCR- 2019/04/29
CRDT- 2019/05/01 06:00
PHST- 2018/09/12 00:00 [received]
PHST- 2019/04/15 00:00 [accepted]
PHST- 2019/05/01 06:00 [entrez]
PHST- 2019/05/01 06:00 [pubmed]
PHST- 2020/01/29 06:00 [medline]
PHST- 2019/04/29 00:00 [pmc-release]
AID - 10.1186/s12877-019-1137-8 [pii]
AID - 1137 [pii]
AID - 10.1186/s12877-019-1137-8 [doi]
PST - epublish
SO  - BMC Geriatr. 2019 Apr 29;19(1):122. doi: 10.1186/s12877-019-1137-8.