PMID- 31036516
OWN - NLM
STAT- MEDLINE
DCOM- 20191206
LR  - 20191217
IS  - 1473-0502 (Print)
IS  - 1473-0502 (Linking)
VI  - 58
IP  - 3
DP  - 2019 Jun
TI  - The Turkish experience with therapeutic plasma exchange: A national survey.
PG  - 287-292
LID - S1473-0502(19)30064-3 [pii]
LID - 10.1016/j.transci.2019.04.015 [doi]
AB  - Therapeutic plasma exchange (TPE) is used to treat more than 60 diseases 
      worldwide and has drawn growing interest. Little is known about the current 
      situation of TPE activity in Turkey, so we developed a survey to obtain 
      information about this timely topic. We collected data on TPE from 28 apheresis 
      units throughout Turkey. We performed a total of 24,912 TPE procedures with 3203 
      patients over the past decade. Twenty years ago, the majority of procedures were 
      performed for neurological and hematological disorders, and today, most TPE 
      procedures are done for the same reasons. The only historical change has been an 
      increase in TPE procedures in renal conditions. Currently, renal conditions were 
      more frequently an indication for TPE than rheumatic conditions. Fresh frozen 
      plasma was the most frequently used replacement fluid, followed by 5% albumin, 
      used in 57.9% and 34.6% of procedures, respectively. The most frequently used 
      anticoagulants in TPE were ACD-A and heparin/ACD-A, used with 1671 (52.2%) and 
      1164 (36.4%) patients, respectively. The frequency of adverse events (AEs) was 
      12.6%. The most common AEs were hypocalcemia-related symptoms, hypotension, and 
      urticaria. We encountered no severe AEs that led to severe morbidity and 
      mortality. Overall, more than two thirds of the patients showed improvement in 
      the underlying disease. Here, we report on a nationwide survey on TPE activity in 
      Turkey. We conclude that there has been a great increase in apheresis science, 
      and the number of TPE procedures conducted in Turkey has increased steadily over 
      time. Finally, we would like to point out that our past experiences and published 
      international guidelines were the most important tools in gaining expertise 
      regarding TPE.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Korkmaz, Serdal
AU  - Korkmaz S
AD  - University of Health Sciences, Kayseri Training and Research Hospital, Department 
      of Hematology, Kayseri, Turkey. Electronic address: baranserdalkorkmaz@gmail.com.
FAU - Solmaz Medeni, Serife
AU  - Solmaz Medeni S
AD  - University of Health Sciences, Bozyaka Training and Research Hospital, Department 
      of Hematology, Izmir, Turkey.
FAU - Demirkan, Fatih
AU  - Demirkan F
AD  - Dokuz Eylul University, Faculty of Medicine, Department of Internal Medicine, 
      Division of Hematology, HCT Unit, Izmir, Turkey.
FAU - Kalayoglu Besisik, Sevgi
AU  - Kalayoglu Besisik S
AD  - Istanbul University, Istanbul Medical Faculty, Department of Internal Medicine, 
      Division of Hematology, Istanbul, Turkey.
FAU - Altay Dadin, Senem
AU  - Altay Dadin S
AD  - Istanbul University, Istanbul Medical Faculty, Department of Internal Medicine, 
      Division of Hematology, Istanbul, Turkey.
FAU - Akgun Cagliyan, Gulsum
AU  - Akgun Cagliyan G
AD  - Pamukkale University, Department of Internal Medicine, Division of Hematology, 
      Denizli, Turkey.
FAU - Kabukcu Hacioglu, Sibel
AU  - Kabukcu Hacioglu S
AD  - Pamukkale University, Department of Internal Medicine, Division of Hematology, 
      Denizli, Turkey.
FAU - Sari, Ismail
AU  - Sari I
AD  - Pamukkale University, Department of Internal Medicine, Division of Hematology, 
      Denizli, Turkey.
FAU - Goren Sahin, Deniz
AU  - Goren Sahin D
AD  - Istanbul Bilim University Medical School, Department of Hematology, Istanbul, 
      Turkey; Sisli Florence Nightingale Hospital, Stem Cell Transplantation Unit, 
      Istanbul, Turkey.
FAU - Arat, Mutlu
AU  - Arat M
AD  - Sisli Florence Nightingale Hospital, Stem Cell Transplantation Unit, Istanbul, 
      Turkey.
FAU - Dagdas, Simten
AU  - Dagdas S
AD  - Ankara Numune Training and Research Hospital, Department of Hematology, Ankara, 
      Turkey.
FAU - Ozet, Gulsum
AU  - Ozet G
AD  - Ankara Numune Training and Research Hospital, Department of Hematology, Ankara, 
      Turkey.
FAU - Kutlu, Nermin
AU  - Kutlu N
AD  - Hacettepe University, School of Medicine, Therapeutic Apheresis Unit, Ankara, 
      Turkey.
FAU - Karaagac Akyol, Tulay
AU  - Karaagac Akyol T
AD  - Hacettepe University, School of Medicine, Therapeutic Apheresis Unit, Ankara, 
      Turkey.
FAU - Ozcebe, Osman Ilhami
AU  - Ozcebe OI
AD  - Hacettepe University, School of Medicine, Department of Hematology, Ankara, 
      Turkey.
FAU - Uskudar Teke, Hava
AU  - Uskudar Teke H
AD  - Eskisehir Osmangazi University, School of Medicine, Department of Internal 
      Medicine, Division of Hematology, Eskisehir, Turkey.
FAU - Kiper Unal, Demet
AU  - Kiper Unal D
AD  - Izmir Katip Celebi University, Ataturk Training and Research Hospital, Department 
      of Hematology, Izmir, Turkey.
FAU - Guner, Naile
AU  - Guner N
AD  - Izmir Katip Celebi University, Ataturk Training and Research Hospital, Department 
      of Hematology, Izmir, Turkey.
FAU - Tombak, Anil
AU  - Tombak A
AD  - Mersin University, Faculty of Medicine, Department of Internal Medicine, Division 
      of Heamatology, Mersin, Turkey.
FAU - Celik, Halil
AU  - Celik H
AD  - Mersin University, Faculty of Medicine, Department of Internal Medicine, Mersin, 
      Turkey.
FAU - Bay, Ilker
AU  - Bay I
AD  - Ataturk University, School of Medicine, Department of Internal Medicine, Division 
      of Hematology, Erzurum, Turkey.
FAU - Kiki, Ilhami
AU  - Kiki I
AD  - Ataturk University, School of Medicine, Department of Internal Medicine, Division 
      of Hematology, Erzurum, Turkey.
FAU - Ozgur, Gokhan
AU  - Ozgur G
AD  - Gulhane Training and Research Hospital, Hematology and HCT Clinic, Ankara, 
      Turkey.
FAU - Erkurt, Mehmet Ali
AU  - Erkurt MA
AD  - Inonu University, Faculty of Medicine, Department of Internal Medicine, Division 
      of Hematology, Malatya, Turkey.
FAU - Ozatli, Duzgun
AU  - Ozatli D
AD  - Ondokuz Mayis University, Faculty of Medicine, Department of Hematology, Samsun, 
      Turkey.
FAU - Meletli, Ozgur
AU  - Meletli O
AD  - Ondokuz Mayis University, Faculty of Medicine, Department of Hematology, Samsun, 
      Turkey.
FAU - Demircioglu, Sinan
AU  - Demircioglu S
AD  - Yuzuncu Yil University, Faculty of Medicine, Department of Internal Medicine, 
      Division of Hematology, Van, Turkey.
FAU - Demir, Cengiz
AU  - Demir C
AD  - Yuzuncu Yil University, Faculty of Medicine, Department of Internal Medicine, 
      Division of Hematology, Van, Turkey.
FAU - Kurtoglu, Erdal
AU  - Kurtoglu E
AD  - University of Health Sciences, Antalya Training and Research Hospital, Department 
      of Hematology, Antalya, Turkey.
FAU - Vural, Filiz
AU  - Vural F
AD  - Ege University, Faculty of Medicine, Department of Internal Medicine, Division of 
      Hematology, Izmir, Turkey.
FAU - Tobu, Mahmut
AU  - Tobu M
AD  - Ege University, Faculty of Medicine, Department of Internal Medicine, Division of 
      Hematology, Izmir, Turkey.
FAU - Karakus, Abdullah
AU  - Karakus A
AD  - Dicle University, Faculty of Medicine, Department of Internal Medicine, Division 
      of Hematology, Diyarbakir, Turkey.
FAU - Ayyildiz, Orhan
AU  - Ayyildiz O
AD  - Dicle University, Faculty of Medicine, Department of Internal Medicine, Division 
      of Hematology, Diyarbakir, Turkey.
FAU - Dal, Mehmet Sinan
AU  - Dal MS
AD  - University of Health Sciences, Ankara Oncology Training and Research Hospital, 
      Department of Hematology and BMT Unit, Ankara, Turkey.
FAU - Afacan Ozturk, Berna
AU  - Afacan Ozturk B
AD  - University of Health Sciences, Diskapi Yildirim Beyazit Training and Research 
      Hospital, Hematology and HCT Clinic, Ankara, Turkey.
FAU - Albayrak, Murat
AU  - Albayrak M
AD  - University of Health Sciences, Diskapi Yildirim Beyazit Training and Research 
      Hospital, Hematology and HCT Clinic, Ankara, Turkey.
FAU - Ocakci, Serkan
AU  - Ocakci S
AD  - Medical Park Izmir Hospital, Department of Hematology, Izmir, Turkey.
FAU - Bolaman, Zahit
AU  - Bolaman Z
AD  - Adnan Menderes University, Faculty of Medicine, Department of Internal Medicine, 
      Division of Hematology, Aydin, Turkey.
FAU - Sonmez, Mehmet
AU  - Sonmez M
AD  - Karadeniz Technical University, Faculty of Medicine, Department of Internal 
      Medicine, Division of Hematology, Trabzon, Turkey.
FAU - Karakus, Volkan
AU  - Karakus V
AD  - Mugla Sitki Kocman University Training and Research Hospital, Department of 
      Hematology, Mugla, Turkey.
FAU - Gokmen Sevindik, Omur
AU  - Gokmen Sevindik O
AD  - Firat University, Faculty of Medicine, Department of Internal Medicine, Division 
      of Hematology, Elazig, Turkey.
FAU - Berber, Ilhami
AU  - Berber I
AD  - Malatya Training and Research Hospital, Division of Hematology, Malatya, Turkey.
FAU - Dogu, Mehmet Hilmi
AU  - Dogu MH
AD  - Istanbul Training and Research Hospital, Hematology Clinic, Istanbul, Turkey.
FAU - Gulturk, Emine
AU  - Gulturk E
AD  - Kartal Dr. Lutfi Kirdar Training and Research Hospital, Department of Internal 
      Medicine, Division of Hematology, Istanbul, Turkey.
FAU - Ulas, Turgay
AU  - Ulas T
AD  - Near East University, Department of Internal Medicine, Division of Hematology, 
      Nicosia, Cyprus.
FAU - Payzin, Bahriye
AU  - Payzin B
AD  - Izmir Katip Celebi University, Ataturk Training and Research Hospital, Department 
      of Hematology, Izmir, Turkey.
FAU - Kuku, Irfan
AU  - Kuku I
AD  - Inonu University, Faculty of Medicine, Department of Internal Medicine, Division 
      of Hematology, Malatya, Turkey.
FAU - Cagirgan, Seckin
AU  - Cagirgan S
AD  - Adnan Menderes University, Faculty of Medicine, Department of Internal Medicine, 
      Division of Hematology, Aydin, Turkey.
FAU - Altuntas, Fevzi
AU  - Altuntas F
AD  - University of Health Sciences, Ankara Oncology Training and Research Hospital, 
      Department of Hematology and BMT Unit, Ankara, Turkey; Yildirim Beyazit 
      University, Faculty of Medicine, Department of Internal Medicine, Division of 
      Hematology, Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20190423
PL  - England
TA  - Transfus Apher Sci
JT  - Transfusion and apheresis science : official journal of the World Apheresis 
      Association : official journal of the European Society for Haemapheresis
JID - 101095653
RN  - 0 (Anticoagulants)
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticoagulants/*administration & dosage/adverse effects
MH  - *Blood Component Removal
MH  - Female
MH  - *Hematologic Diseases/metabolism/pathology/therapy
MH  - Humans
MH  - Hypocalcemia/etiology/mortality
MH  - Hypotension/etiology/mortality
MH  - Male
MH  - Middle Aged
MH  - *Nervous System Diseases/epidemiology/mortality/therapy
MH  - *Plasma
MH  - *Plasma Exchange
MH  - Turkey/epidemiology
MH  - Urticaria/etiology/mortality
OTO - NOTNLM
OT  - National survey
OT  - Therapeutic plasma exchange
OT  - Turkish experience
EDAT- 2019/05/01 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/05/01 06:00
PHST- 2019/05/01 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/05/01 06:00 [entrez]
AID - S1473-0502(19)30064-3 [pii]
AID - 10.1016/j.transci.2019.04.015 [doi]
PST - ppublish
SO  - Transfus Apher Sci. 2019 Jun;58(3):287-292. doi: 10.1016/j.transci.2019.04.015. 
      Epub 2019 Apr 23.