PMID- 31037370
OWN - NLM
STAT- MEDLINE
DCOM- 20190718
LR  - 20190718
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 411
IP  - 18
DP  - 2019 Jul
TI  - Performance of atmospheric pressure gas chromatography-tandem mass spectrometry 
      for the analysis of organochlorine pesticides in human serum.
PG  - 4185-4191
LID - 10.1007/s00216-019-01822-1 [doi]
AB  - A novel method of atmospheric pressure gas chromatography-tandem mass 
      spectrometry (APGC-MS/MS) for the analysis of organochlorine pesticides (OCPs) in 
      human serum was developed. Better sensitivity and selectivity were achieved 
      compared to conventional gas chromatography-mass spectrometry (GC-MS) and 
      GC-MS/MS. The limits of detection (LODs) of OCPs ranged from 0.22 to 0.90 pg/mL 
      for the analysis in serum samples. The recoveries and repeatability of the 
      developed method were evaluated from the analysis of spiked serum at three levels 
      (0.05, 0.5, and 5 ng/mL). The recoveries ranged from 84.5 to 118.2%, and the 
      relative standard deviations (RSDs) were less than 20%. The developed APGC-MS/MS 
      method was applied to measure OCPs in pooled human serum from the interlaboratory 
      comparison study. The obtained results of OCPs were within the acceptable ranges. 
      The method has been successfully applied to the analysis of OCPs in human serum 
      samples with the sample volume of up to 100 muL. Graphical abstract.
FAU - Fang, Jing
AU  - Fang J
AD  - State Key Laboratory of Environmental and Biological Analysis, Department of 
      Chemistry, Hong Kong Baptist University, Kowlong Tong, Hong Kong, SAR, China.
FAU - Zhao, Hongzhi
AU  - Zhao H
AD  - State Key Laboratory of Environmental and Biological Analysis, Department of 
      Chemistry, Hong Kong Baptist University, Kowlong Tong, Hong Kong, SAR, China.
FAU - Zhang, Yanhao
AU  - Zhang Y
AD  - State Key Laboratory of Environmental and Biological Analysis, Department of 
      Chemistry, Hong Kong Baptist University, Kowlong Tong, Hong Kong, SAR, China.
FAU - He, Yu
AU  - He Y
AD  - State Key Laboratory of Environmental and Biological Analysis, Department of 
      Chemistry, Hong Kong Baptist University, Kowlong Tong, Hong Kong, SAR, China.
AD  - MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of 
      Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China.
FAU - Sun, Qianqian
AU  - Sun Q
AD  - MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of 
      Chemistry, Fuzhou University, Fuzhou, 350116, Fujian, China.
FAU - Xu, Shunqing
AU  - Xu S
AD  - Key Laboratory of Environment and Health, Ministry of Education & Ministry of 
      Environmental Protection, and State Key Laboratory of Environmental Health 
      (Incubation), School of Public Health, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430030, Hubei, China. 
      xust@hust.edu.cn.
FAU - Cai, Zongwei
AU  - Cai Z
AD  - State Key Laboratory of Environmental and Biological Analysis, Department of 
      Chemistry, Hong Kong Baptist University, Kowlong Tong, Hong Kong, SAR, China. 
      zwcai@hkbu.edu.hk.
LA  - eng
GR  - 21437002/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20190430
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
SB  - IM
MH  - Atmospheric Pressure
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Limit of Detection
MH  - Pesticides/*blood
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - APGC
OT  - Human serum
OT  - OCPs
EDAT- 2019/05/01 06:00
MHDA- 2019/07/19 06:00
CRDT- 2019/05/01 06:00
PHST- 2018/12/30 00:00 [received]
PHST- 2019/03/29 00:00 [accepted]
PHST- 2019/02/15 00:00 [revised]
PHST- 2019/05/01 06:00 [pubmed]
PHST- 2019/07/19 06:00 [medline]
PHST- 2019/05/01 06:00 [entrez]
AID - 10.1007/s00216-019-01822-1 [pii]
AID - 10.1007/s00216-019-01822-1 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2019 Jul;411(18):4185-4191. doi: 10.1007/s00216-019-01822-1. 
      Epub 2019 Apr 30.