PMID- 31037565 OWN - NLM STAT- MEDLINE DCOM- 20210726 LR - 20210726 IS - 1868-601X (Electronic) IS - 1868-4483 (Linking) VI - 11 IP - 1 DP - 2020 Feb TI - Strictly Lobar Cerebral Microbleeds Are Associated with Increased White Matter Volume. PG - 29-38 LID - 10.1007/s12975-019-00704-z [doi] AB - Cerebral small vessel diseases (CSVD), such as white matter hyperintensities (WMH), have been acknowledged as a cause of brain atrophy. However, the relationship between brain volumes and cerebral microbleeds (CMBs) has not yet been determined. We aimed to evaluate whether the presence and topography of CMBs are associated with altered volumes of gray matter (GMV) and white matter (WMV). Non-stroke and non-demented subjects were prospectively recruited from the I-Lan Longitudinal Aging Study. High-resolution 3-T MRI was performed to quantify total and regional WMV and GMV, including Alzheimer's disease-susceptible areas. CMBs were assessed with susceptibility-weighted imaging. Six hundred and fifty-nine subjects (62.1 +/- 8.3 years, 290 (44%) men) were included. Thirty-two (4.9%) subjects had strictly lobar CMBs (SL-CMBs) and 51 (7.7%) had deep or infratentorial CMBs (DI-CMBs). We observed an association between CMBs and WMV, independent of age, sex, and vascular risk factors; the direction of association depended on the location of the CMBs. The SL-CMB group had an increased total, frontal, and occipital WMV compared with the no-CMB group, which remained significant after adjusting for other CSVDs (WMH volumes and lacune numbers). In contrast, the DI-CMB group had a decreased occipital WMV compared to the no-CMB group. However, this significance disappeared after taking other CSVDs into consideration. Our results showed no relationship between CMBs and GMV. In conclusion, the increased WMV in non-stroke, non-demented subjects with SL-CMBs observed here provides insight into the early pathogenesis of SL-CMBs. This may be a result of increased water content or amyloid accumulation. FAU - Wang, Pei-Ning AU - Wang PN AD - Department of Neurology, National Yang Ming University, Taipei, Taiwan. AD - Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan. AD - Brain Research Center, National Yang Ming University, Taipei, Taiwan. AD - Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan. FAU - Chou, Kun-Hsien AU - Chou KH AD - Brain Research Center, National Yang Ming University, Taipei, Taiwan. AD - School of Medicine, Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan. FAU - Peng, Li-Ning AU - Peng LN AD - Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan. AD - Department of Gerontology, National Yang Ming University, Taipei, Taiwan. AD - Center for Geriatric and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan. FAU - Liu, Li-Kuo AU - Liu LK AD - Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan. AD - Department of Gerontology, National Yang Ming University, Taipei, Taiwan. AD - Center for Geriatric and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan. FAU - Lee, Wei-Ju AU - Lee WJ AD - Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan. AD - Department of Gerontology, National Yang Ming University, Taipei, Taiwan. AD - Institute of Public Health, National Yang Ming University, Taipei, Taiwan. AD - Department of Family Medicine, Taipei Veterans General Hospital Yuanshan Branch, Yilan, Taiwan. FAU - Chen, Liang-Kung AU - Chen LK AD - Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan. AD - Department of Gerontology, National Yang Ming University, Taipei, Taiwan. AD - Center for Geriatric and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan. FAU - Lin, Ching-Po AU - Lin CP AD - Brain Research Center, National Yang Ming University, Taipei, Taiwan. AD - School of Medicine, Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan. FAU - Chung, Chih-Ping AU - Chung CP AUID- ORCID: 0000-0001-9419-9070 AD - Department of Neurology, National Yang Ming University, Taipei, Taiwan. cpchung@vghtpe.gov.tw. AD - Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan. cpchung@vghtpe.gov.tw. AD - Department of Neurology, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei, 112, Taiwan. cpchung@vghtpe.gov.tw. LA - eng GR - MOST 104-2314-B-075-MY3/Ministry of Science and Technology, Taiwan/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190429 PL - United States TA - Transl Stroke Res JT - Translational stroke research JID - 101517297 SB - IM MH - Aged MH - Aged, 80 and over MH - Brain/blood supply/diagnostic imaging/*pathology MH - Cerebral Hemorrhage/complications/diagnostic imaging/*pathology MH - Cerebral Small Vessel Diseases/complications/diagnostic imaging/*pathology MH - Female MH - Gray Matter/diagnostic imaging/pathology MH - Humans MH - Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - Prospective Studies MH - White Matter/diagnostic imaging/*pathology OTO - NOTNLM OT - Brain volume OT - Cerebral microbleeds OT - White matter volume EDAT- 2019/05/01 06:00 MHDA- 2021/07/27 06:00 CRDT- 2019/05/01 06:00 PHST- 2018/11/05 00:00 [received] PHST- 2019/03/28 00:00 [accepted] PHST- 2019/03/21 00:00 [revised] PHST- 2019/05/01 06:00 [pubmed] PHST- 2021/07/27 06:00 [medline] PHST- 2019/05/01 06:00 [entrez] AID - 10.1007/s12975-019-00704-z [pii] AID - 10.1007/s12975-019-00704-z [doi] PST - ppublish SO - Transl Stroke Res. 2020 Feb;11(1):29-38. doi: 10.1007/s12975-019-00704-z. Epub 2019 Apr 29.