PMID- 31037832
OWN - NLM
STAT- MEDLINE
DCOM- 20200218
LR  - 20230919
IS  - 2211-5463 (Electronic)
IS  - 2211-5463 (Linking)
VI  - 9
IP  - 7
DP  - 2019 Jul
TI  - LncRNA MALAT1 increases the stemness of gastric cancer cells via enhancing SOX2 
      mRNA stability.
PG  - 1212-1222
LID - 10.1002/2211-5463.12649 [doi]
AB  - Gastric cancer is one of the most common malignancies globally; cancer stem cells 
      (CSCs) are regarded as being at the root of tumor progression, and there is thus 
      a need to identify potential drugs to target CSCs. The long non-coding RNA MALAT1 
      promotes epithelial-mesenchymal transition and angiogenesis in colorectal cancer, 
      but it is unknown whether it affects the stemness of gastric cancer cells. Here, 
      we found that knockdown (KD) of MALAT1 attenuated the stemness of non-adherent 
      gastric cancer cell spheroids, as evidenced by a decrease in primary and 
      secondary spheroid formation capacity and expression of stemness markers. In 
      contrast, overexpression (OE) of MALAT1 enhanced the stemness of adherent gastric 
      cancer cells. Notably, KD of MALAT1 enhanced radiosensitivity and 
      chemosensitivity of gastric cancer cell spheroids. We report that MALAT1 directly 
      binds to sox2 mRNA (which encodes a critical master pluripotency factor), 
      enhances the mRNA stability and increases its expression; KD of sox2 partially 
      reversed the effect of MALAT1 OE on the stemness of gastric cancer cells. 
      Importantly, expression of MALAT1 and sox2 exhibited a positive correlation in 
      clinical samples. Therefore, our results indicate the existence of a novel 
      MALAT1-sox2 axis which promotes the stemness of gastric cancer cells and may be a 
      potential target for gastric cancer.
CI  - (c) The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
FAU - Xiao, Yiwen
AU  - Xiao Y
AD  - Department of Oncology, Changzhou Second People's Hospital, China.
FAU - Pan, Jingjing
AU  - Pan J
AD  - Department of Oncology, Changzhou Second People's Hospital, China.
FAU - Geng, Qian
AU  - Geng Q
AD  - Department of Oncology, Changzhou Second People's Hospital, China.
FAU - Wang, Ge
AU  - Wang G
AD  - Department of Oncology, Changzhou Second People's Hospital, China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20190602
PL  - England
TA  - FEBS Open Bio
JT  - FEBS open bio
JID - 101580716
RN  - 0 (MALAT1 long non-coding RNA, human)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (RNA, Messenger)
RN  - 0 (SOX2 protein, human)
RN  - 0 (SOXB1 Transcription Factors)
SB  - IM
RIN - FEBS Open Bio. 2023 Sep 19;:. PMID: 37724913
MH  - Cell Differentiation/*genetics
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - Drug Resistance, Neoplasm
MH  - Epithelial-Mesenchymal Transition
MH  - Humans
MH  - Neoplastic Stem Cells/metabolism/*pathology
MH  - RNA Stability
MH  - RNA, Long Noncoding/genetics/*metabolism
MH  - RNA, Messenger/genetics
MH  - SOXB1 Transcription Factors/*genetics/metabolism
MH  - Spheroids, Cellular
MH  - Stomach Neoplasms/*genetics/metabolism/pathology
PMC - PMC6609564
OTO - NOTNLM
OT  - Sox2
OT  - MALAT1
OT  - chemosensitivity
OT  - gastric cancer
OT  - radiosensitivity
OT  - stemness
COIS- The authors declare no conflict of interest.
EDAT- 2019/05/01 06:00
MHDA- 2020/02/19 06:00
PMCR- 2019/06/02
CRDT- 2019/05/01 06:00
PHST- 2019/03/13 00:00 [received]
PHST- 2019/04/15 00:00 [revised]
PHST- 2019/04/25 00:00 [accepted]
PHST- 2019/05/01 06:00 [pubmed]
PHST- 2020/02/19 06:00 [medline]
PHST- 2019/05/01 06:00 [entrez]
PHST- 2019/06/02 00:00 [pmc-release]
AID - FEB412649 [pii]
AID - 10.1002/2211-5463.12649 [doi]
PST - ppublish
SO  - FEBS Open Bio. 2019 Jul;9(7):1212-1222. doi: 10.1002/2211-5463.12649. Epub 2019 
      Jun 2.