PMID- 31037926
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2008-076X (Print)
IS  - 2008-0778 (Electronic)
IS  - 2008-0778 (Linking)
VI  - 13
IP  - 2
DP  - 2019 Jul
TI  - Impact of Metformin and Pioglitazone on Serum Level of Tumor Necrosis 
      Factor-Alpha and Lipid Profiles during Implantation Window in Diabetic Rats.
PG  - 148-153
LID - 10.22074/ijfs.2019.5636 [doi]
AB  - BACKGROUND: The present study was designed to evaluate serum lipid profile and 
      tumor necrosis factor-alpha (TNF-a) level in diabetic rats at implantation time. 
      Type 2 diabetes mellitus (T2DM) could affect various systems, including innate 
      immune system and it causes chronic low-grade inflammation, increasing level of 
      TNF-a. Furthermore, T2DM is often accompanied by impaired lipid profile. 
      Metformin and pioglitazone are used as the first and second lines of treatment 
      for T2DM. MATERIALS AND METHODS: In this experimental study, 35 adult virgin 
      female wistar rats, weighting 175-225 g, were randomly categorized into five 
      groups: i. Control, ii. Sham, iii. Nicotinamide (NA)+streptozotocin (STZ) induced 
      T2DM, iv. Diabetic+pioglitazone (20 mg/kg/day for 28 days oral administration), 
      and v. Diabetic+metformin (100 mg/kg/day for 28 days oral administration). At the 
      time of implantation, TNF-a level in serum of rats was measured by ELISA kit. 
      Glucose was measured using photometric method and lipid profiles were calculated 
      by enzymatic methods. RESULTS: Level of TNF-a in the diabetic group was 
      significantly higher than other groups (P<0.001). In metformin treated group, 
      TNF-a serum level was also significantly higher than pioglitazone treated group 
      (P<0.001). Fasting blood sugar (FBS) and lipid profiles were significantly higher 
      in diabetic group. CONCLUSION: Metformin and pioglitazone have similar effects on 
      glucose, lipid profiles and TNF-a serum levels. Among these drugs, pioglitazone 
      has more efficient influence on TNF-alpha serum level, in comparison with metformin.
CI  - Copyright(c) by Royan Institute. All rights reserved.
FAU - Bakhteyari, Abbas
AU  - Bakhteyari A
AD  - Department of Anatomical Sciences, Faculty of Medicine, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
FAU - Nikpour, Parvaneh
AU  - Nikpour P
AD  - Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
AD  - Child Growth and Development Research Center, Research Institute for Primordial 
      Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
FAU - Mostafavi, Fatemah Sadat
AU  - Mostafavi FS
AD  - Department of Anatomical Sciences, Faculty of Medicine, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
FAU - Eskandari, Nahid
AU  - Eskandari N
AD  - Department of Immunology, Faculty of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Matinfar, Mohammad
AU  - Matinfar M
AD  - Department of Internal Medicine Faculty of Medicine, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
FAU - Soleimani Asl, Sara
AU  - Soleimani Asl S
AD  - Endometrium and Endometriosis Research Center, Hamedan University of Medical 
      Sciences, Hamedan, Iran.
FAU - Aboutorabi, Roshanak
AU  - Aboutorabi R
AD  - Department of Anatomical Sciences, Faculty of Medicine, Isfahan University of 
      Medical Sciences, Isfahan, Iran.Electronic Address: abutorabi@med.mui.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20190427
PL  - Iran
TA  - Int J Fertil Steril
JT  - International journal of fertility & sterility
JID - 101487941
PMC - PMC6500083
OTO - NOTNLM
OT  - Diabetes Mellitus
OT  - Embryo Implantation
OT  - Metformin
OT  - Pioglitazone
OT  - Tumor Necrosis Factor-Alpha
COIS- The authors declare no conflicts of interest.
EDAT- 2019/05/01 06:00
MHDA- 2019/05/01 06:01
PMCR- 2019/07/01
CRDT- 2019/05/01 06:00
PHST- 2018/07/02 00:00 [received]
PHST- 2018/11/13 00:00 [accepted]
PHST- 2019/05/01 06:00 [entrez]
PHST- 2019/05/01 06:00 [pubmed]
PHST- 2019/05/01 06:01 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - 10.22074/ijfs.2019.5636 [doi]
PST - ppublish
SO  - Int J Fertil Steril. 2019 Jul;13(2):148-153. doi: 10.22074/ijfs.2019.5636. Epub 
      2019 Apr 27.