PMID- 31038770
OWN - NLM
STAT- MEDLINE
DCOM- 20200504
LR  - 20200505
IS  - 1440-1746 (Electronic)
IS  - 0815-9319 (Linking)
VI  - 34
IP  - 10
DP  - 2019 Oct
TI  - Effects of smoking on the association of human leukocyte antigen with ulcerative 
      colitis.
PG  - 1777-1783
LID - 10.1111/jgh.14695 [doi]
AB  - BACKGROUND AND AIM: Tobacco smoking is a risk factor for gastrointestinal 
      disorders, causing mucosal damage and impairing immune responses. However, 
      smoking has been found to be protective against ulcerative colitis (UC). Human 
      leukocyte antigen (HLA) is a major susceptibility locus for UC, and 
      HLA-DRB1*15:02 has the strongest effect in Asians. This study investigated the 
      effects of smoking on the association between HLA and UC. METHODS: The study 
      enrolled 882 patients with UC, including 526 never, 151 current, and 205 former 
      smokers, and 3091 healthy controls, including 2124 never, 502 current, and 465 
      former smokers. Smoking-stratified analyses of HLA data were performed using a 
      case-control approach. RESULTS: In a case-control approach, HLA-DRB1*15:02 was 
      associated with UC in never smokers (OR(never smokers)  = 3.20, P(never smokers) 
       = 7.88 x 10(-23) ) but not in current or former smokers (P(current smokers) 
       = 0.72 and P(former smokers)  = 0.33, respectively). In current smokers, 
      HLA-DQB1*06 was associated with UC (OR(current smokers)  = 2.59, P(current 
      smokers)  = 6.39 x 10(-12) ). No variants reached genome-wide significance in 
      former smokers. CONCLUSIONS: An association between UC and HLA-DRB1*15:02 was 
      limited to never smokers. Our findings highlight that tobacco smoking modifies 
      the effects of HLA on the risk of UC.
CI  - (c) 2019 Journal of Gastroenterology and Hepatology Foundation and John Wiley & 
      Sons Australia, Ltd.
FAU - Lee, Ho-Su
AU  - Lee HS
AD  - Department of Biochemistry and Molecular Biology, University of Ulsan College of 
      Medicine, Seoul, Republic of Korea.
AD  - Stem Cell Immunomodulation Research Center, University of Ulsan College of 
      Medicine, Seoul, Republic of Korea.
FAU - Kim, Kihyun
AU  - Kim K
AD  - Department of Biochemistry and Molecular Biology, University of Ulsan College of 
      Medicine, Seoul, Republic of Korea.
FAU - Jung, Seulgi
AU  - Jung S
AD  - Department of Biochemistry and Molecular Biology, University of Ulsan College of 
      Medicine, Seoul, Republic of Korea.
FAU - Hong, Myunghee
AU  - Hong M
AD  - Department of Biochemistry and Molecular Biology, University of Ulsan College of 
      Medicine, Seoul, Republic of Korea.
FAU - Kim, Byoung Mok
AU  - Kim BM
AD  - Department of Biochemistry and Molecular Biology, University of Ulsan College of 
      Medicine, Seoul, Republic of Korea.
FAU - Yoo, Dae-Sung
AU  - Yoo DS
AD  - Division of Veterinary Epidemiology, Animal and Plant Quarantine Agency, Ministry 
      of Agriculture Food and Rural Affair, Gimcheon, Republic of Korea.
FAU - Moon, Jung Won
AU  - Moon JW
AD  - Department of Biochemistry and Molecular Biology, University of Ulsan College of 
      Medicine, Seoul, Republic of Korea.
FAU - Baek, Jiwon
AU  - Baek J
AD  - Department of Biochemistry and Molecular Biology, University of Ulsan College of 
      Medicine, Seoul, Republic of Korea.
FAU - Hwang, Sung Wook
AU  - Hwang SW
AD  - Department of Gastroenterology and Inflammatory Bowel Disease Center, Asan 
      Medical Center, University of Ulsan College of Medicine, Seoul, Republic of 
      Korea.
FAU - Park, Sang Hyoung
AU  - Park SH
AD  - Department of Gastroenterology and Inflammatory Bowel Disease Center, Asan 
      Medical Center, University of Ulsan College of Medicine, Seoul, Republic of 
      Korea.
FAU - Yang, Suk-Kyun
AU  - Yang SK
AD  - Department of Gastroenterology and Inflammatory Bowel Disease Center, Asan 
      Medical Center, University of Ulsan College of Medicine, Seoul, Republic of 
      Korea.
FAU - Han, Buhm
AU  - Han B
AD  - Department of Medicine, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Song, Kyuyoung
AU  - Song K
AD  - Department of Biochemistry and Molecular Biology, University of Ulsan College of 
      Medicine, Seoul, Republic of Korea.
FAU - Ye, Byong Duk
AU  - Ye BD
AD  - Department of Gastroenterology and Inflammatory Bowel Disease Center, Asan 
      Medical Center, University of Ulsan College of Medicine, Seoul, Republic of 
      Korea.
LA  - eng
GR  - 2018R1A5A2020732/National Research Foundation of Korea (NRF) MRC grant/
GR  - 2017R1A2A1A05001119/Mid-Career Researcher Program grant from the National 
      Research Foundation of Korea/
PT  - Comparative Study
PT  - Journal Article
DEP - 20190619
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*15:20 antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Colitis, Ulcerative/diagnosis/*genetics/immunology
MH  - Female
MH  - *Gene-Environment Interaction
MH  - HLA-DRB1 Chains/*genetics/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Non-Smokers
MH  - Risk Assessment
MH  - Risk Factors
MH  - *Smokers
MH  - Smoking/adverse effects/*genetics/immunology
MH  - Smoking Cessation
OTO - NOTNLM
OT  - HLA
OT  - gene-environment interaction
OT  - smoking
OT  - ulcerative colitis
EDAT- 2019/05/01 06:00
MHDA- 2020/05/06 06:00
CRDT- 2019/05/01 06:00
PHST- 2019/02/14 00:00 [received]
PHST- 2019/04/16 00:00 [revised]
PHST- 2019/04/17 00:00 [accepted]
PHST- 2019/05/01 06:00 [pubmed]
PHST- 2020/05/06 06:00 [medline]
PHST- 2019/05/01 06:00 [entrez]
AID - 10.1111/jgh.14695 [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2019 Oct;34(10):1777-1783. doi: 10.1111/jgh.14695. Epub 
      2019 Jun 19.