PMID- 31039417
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20190613
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Linking)
VI  - 311
DP  - 2019 Sep 1
TI  - Intrauterine programming of the glucocorticoid-insulin-like growth factor 1 
      (GC-IGF1) axis mediates glomerulosclerosis in female adult offspring rats induced 
      by prenatal ethanol exposure.
PG  - 17-26
LID - S0378-4274(19)30112-2 [pii]
LID - 10.1016/j.toxlet.2019.04.022 [doi]
AB  - Prenatal ethanol exposure (PEE) causes intrauterine growth retardation (IUGR), 
      and the occurrence of glomerulosclerosis is closely related to IUGR. This study 
      aimed to confirm the kidney toxic effect of PEE and explore its intrauterine 
      programming mechanism in female offspring. The Wistar female fetuses on 
      gestational day (GD) 20 and the adult offspring at postnatal week 24 were 
      anesthetized and decapitated. The adult offspring kidneys in the PEE group 
      displayed glomerular hyperplasia and glomerulosclerosis. Blood urea nitrogen 
      (BUN) and the BUN / Serum creatinine (Scr) concentration ratio in the PEE group 
      was increased significantly compared to the control group (P<0.01, P<0.05). 
      Meanwhile, the renal glucocorticoid-activation system was inhibited, whereas the 
      insulin-like growth factor 1 (IGF1) signaling pathway was activated in the female 
      adult offspring of the PEE group. In the fetal kidney of the PEE group, 
      pathological observation showed kidney dysplasia, and the gene expression of the 
      glial-cell-line-derived neurotrophic factor/tyrosine kinase receptor (GDNF/c-Ret) 
      signaling pathway was reduced compared to that of the control group. Moreover, 
      the glucocorticoid-activation system was activated, whereas the IGF1 signaling 
      pathway was inhibited in the fetal kidneys of the PEE group. In conclusion, PEE 
      caused fetal kidney dysplasia and adult glomerulosclerosis in the female 
      offspring rats, and the intrauterine programming alteration of 
      glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis might be involved in 
      fetal-originated glomerulosclerosis.
CI  - Published by Elsevier B.V.
FAU - He, Hangyuan
AU  - He H
AD  - Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 
      430071, China; Department of Orthopaedic Surgery, Zhongnan Hospital of Wuhan 
      University, Wuhan, 430071, China.
FAU - Xiong, Ying
AU  - Xiong Y
AD  - Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 
      430071, China.
FAU - Li, Bin
AU  - Li B
AD  - Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 
      430071, China; Department of Orthopaedic Surgery, Zhongnan Hospital of Wuhan 
      University, Wuhan, 430071, China.
FAU - Zhu, Yanan
AU  - Zhu Y
AD  - Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 
      430071, China; Hubei Provincial Key Laboratory of Developmentally Originated 
      Disease, Wuhan, 430071, China.
FAU - Chen, Haiyun
AU  - Chen H
AD  - Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 
      430071, China; Hubei Provincial Key Laboratory of Developmentally Originated 
      Disease, Wuhan, 430071, China.
FAU - Ao, Ying
AU  - Ao Y
AD  - Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 
      430071, China; Hubei Provincial Key Laboratory of Developmentally Originated 
      Disease, Wuhan, 430071, China. Electronic address: yingao@whu.edu.cn.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 
      430071, China; Hubei Provincial Key Laboratory of Developmentally Originated 
      Disease, Wuhan, 430071, China. Electronic address: wanghui19@whu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190427
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Glucocorticoids)
RN  - 0 (insulin-like growth factor-1, rat)
RN  - 3K9958V90M (Ethanol)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-ret)
SB  - IM
MH  - Animals
MH  - Ethanol/*toxicity
MH  - Female
MH  - Fetal Development/drug effects
MH  - Gene Expression Regulation/drug effects
MH  - Gestational Age
MH  - Glial Cell Line-Derived Neurotrophic Factor/genetics/metabolism
MH  - Glucocorticoids/*metabolism
MH  - Insulin-Like Growth Factor I/genetics/*metabolism
MH  - Kidney Diseases/*chemically induced/genetics/metabolism/pathology
MH  - Kidney Glomerulus/*drug effects/metabolism/pathology
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Proto-Oncogene Proteins c-ret/genetics/metabolism
MH  - Rats, Wistar
MH  - Sex Factors
MH  - Signal Transduction/drug effects
OTO - NOTNLM
OT  - Glomerulosclerosis
OT  - Glucocorticoid-activation system
OT  - Glucocorticoid-insulin-like growth factor 1 axis
OT  - Intrauterine programming
OT  - Prenatal ethanol exposure
EDAT- 2019/05/01 06:00
MHDA- 2019/06/14 06:00
CRDT- 2019/05/01 06:00
PHST- 2018/11/29 00:00 [received]
PHST- 2019/03/06 00:00 [revised]
PHST- 2019/04/21 00:00 [accepted]
PHST- 2019/05/01 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2019/05/01 06:00 [entrez]
AID - S0378-4274(19)30112-2 [pii]
AID - 10.1016/j.toxlet.2019.04.022 [doi]
PST - ppublish
SO  - Toxicol Lett. 2019 Sep 1;311:17-26. doi: 10.1016/j.toxlet.2019.04.022. Epub 2019 
      Apr 27.