PMID- 31040268
OWN - NLM
STAT- MEDLINE
DCOM- 20200826
LR  - 20231011
IS  - 2044-4052 (Electronic)
IS  - 2044-4052 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Apr 30
TI  - Association of hemoglobin A1C with circulating metabolites in Dutch with 
      European, African Surinamese and Ghanaian background.
PG  - 15
LID - 10.1038/s41387-019-0082-0 [doi]
LID - 15
AB  - BACKGROUND: The prevalence of type 2 diabetes mellitus (T2DM) varies 
      significantly across ethnic groups. A better understanding of the mechanisms 
      underlying the variation in different ethnic groups may help to elucidate the 
      pathophysiology of T2DM. The present work aims to generate a hypothesis regarding 
      "why do subjects with African background have excess burden of T2DM?". METHODS: 
      In the current study, we performed metabolite profiling of plasma samples derived 
      from 773 subjects of three ethnic groups (Dutch with European, Ghanaian and 
      African Surinamese background). We performed Bayesian lognormal regression 
      analyses to assess associations between HbA1c and circulating metabolites. 
      RESULTS: Here we show that subjects with African Surinamese and Ghanaian 
      background had similar associations of HbA1c with circulating amino acids and 
      triglyceride-rich lipoproteins as subjects with European background. In contrast, 
      subjects with Ghanaian and African Surinamese background had different 
      associations of HbA1c with acetoacetate, small LDL particle and small HDL 
      particle concentrations, compared to the subjects with European background. 
      CONCLUSIONS: On the basis of the observations, we hypothesize that the excess 
      burden of T2DM in subjects with African background may be due to impaired 
      cholesterol efflux capacity or abnormal cholesterol uptake.
FAU - Zhang, Xiang
AU  - Zhang X
AUID- ORCID: 0000-0002-3878-9196
AD  - Department of Experimental Vascular Medicine, Amsterdam University Medical 
      Center, University of Amsterdam, Amsterdam, The Netherlands. 
      xiang.zhang@amsterdamumc.nl.
FAU - van den Munckhof, Inge C L
AU  - van den Munckhof ICL
AD  - Department of Internal Medicine, Radboud university medical center, Nijmegen, The 
      Netherlands.
FAU - Rutten, Joost H W
AU  - Rutten JHW
AD  - Department of Internal Medicine, Radboud university medical center, Nijmegen, The 
      Netherlands.
FAU - Netea, Mihai G
AU  - Netea MG
AD  - Department of Internal Medicine, Radboud university medical center, Nijmegen, The 
      Netherlands.
AD  - Radboud Center for Infectious Diseases, Radboud university medical Center, 
      Nijmegen, The Netherlands.
AD  - Department for Genomics & Immunoregulation, Life and Medical Sciences Institute 
      (LIMES), University of Bonn, Bonn, Germany.
FAU - Groen, Albert K
AU  - Groen AK
AD  - Department of Experimental Vascular Medicine, Amsterdam University Medical 
      Center, University of Amsterdam, Amsterdam, The Netherlands.
AD  - Department of Pediatrics, University Medical Center Groningen, University of 
      Groningen, Groningen, The Netherlands.
FAU - Zwinderman, Aeilko H
AU  - Zwinderman AH
AD  - Clinical Epidemiology, Biostatistics, and Bioinformatics, Amsterdam University 
      Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190430
PL  - England
TA  - Nutr Diabetes
JT  - Nutrition & diabetes
JID - 101566341
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipoproteins)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Black People
MH  - Blood Glucose/metabolism
MH  - Cholesterol/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Glycated Hemoglobin/*analysis
MH  - Humans
MH  - Lipoproteins/blood
MH  - Male
MH  - *Metabolome
MH  - Middle Aged
MH  - Netherlands
MH  - White People
MH  - Young Adult
PMC - PMC6491479
COIS- The authors declare that they have no conflict of interest.
EDAT- 2019/05/02 06:00
MHDA- 2020/08/28 06:00
PMCR- 2019/04/30
CRDT- 2019/05/02 06:00
PHST- 2019/01/09 00:00 [received]
PHST- 2019/04/11 00:00 [accepted]
PHST- 2019/03/28 00:00 [revised]
PHST- 2019/05/02 06:00 [entrez]
PHST- 2019/05/02 06:00 [pubmed]
PHST- 2020/08/28 06:00 [medline]
PHST- 2019/04/30 00:00 [pmc-release]
AID - 10.1038/s41387-019-0082-0 [pii]
AID - 82 [pii]
AID - 10.1038/s41387-019-0082-0 [doi]
PST - epublish
SO  - Nutr Diabetes. 2019 Apr 30;9(1):15. doi: 10.1038/s41387-019-0082-0.