PMID- 31040769
OWN - NLM
STAT- MEDLINE
DCOM- 20200113
LR  - 20200309
IS  - 1662-5110 (Electronic)
IS  - 1662-5110 (Linking)
VI  - 13
DP  - 2019
TI  - Lower Posttraumatic alpha-Synuclein Level Associated With Altered Default Mode 
      Network Connectivity Following Acute Mild Traumatic Brain Injury.
PG  - 26
LID - 10.3389/fncir.2019.00026 [doi]
LID - 26
AB  - This study aimed to investigate the changes of alpha-synuclein in serum and its 
      relationship with default mode network (DMN) connectivity after acute mild 
      traumatic brain injury (mild TBI). Fifty-two patients with mild TBI at the acute 
      phase and 47 matched healthy controls were enrolled in the study. All 
      participants received resting-state functional magnetic resonance imaging (fMRI) 
      and neuropsychological assessments. Relations between the levels of alpha-synuclein 
      in serum and clinical assessments were obtained using multivariate linear 
      regression. Results showed that the patients with lower alpha-synuclein presented 
      more complaints on post-concussion symptoms and depression. Moreover, patients 
      with high levels of alpha-synuclein exhibited significantly decreased functional 
      connectivity in the left precuneus and increased functional connectivity in both 
      the left anterior cingulate cortex and ventro-medial prefrontal cortex (MPFC) 
      compared with patients with low levels of alpha-synuclein. These findings supported 
      that alpha-synuclein may modulate the functional connectivity within the DMN and 
      suggest the feasibility of using alpha-synuclein as an objective biomarker for 
      diagnosis and prognosis of mild TBI.
FAU - Ye, Limei
AU  - Ye L
AD  - Department of Radiology, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, China.
AD  - Department of Radiology, Jinhua Municipal Central Hospital and Jinhua Hospital of 
      Zhejiang University, Jinhua, China.
FAU - Zhang, Danbin
AU  - Zhang D
AD  - Department of Radiology, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Shao, Meihua
AU  - Shao M
AD  - Department of Radiology, Tongde Hospital of Zhejiang Province, Hangzhou, China.
FAU - Zhao, Pinghui
AU  - Zhao P
AD  - Department of Radiology, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Yin, Bo
AU  - Yin B
AD  - Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Zhuang, Jinfei
AU  - Zhuang J
AD  - Department of Rehabilitation, The Second Affiliated Hospital and Yuying 
      Children's Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Wang, Feifei
AU  - Wang F
AD  - Department of MRI, The First Affiliated Hospital of Zhengzhou University, 
      Zhengzhou, China.
FAU - Yan, Zhihan
AU  - Yan Z
AD  - Department of Radiology, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, China.
FAU - Bai, Guanghui
AU  - Bai G
AD  - Department of Radiology, The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University, Wenzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190416
PL  - Switzerland
TA  - Front Neural Circuits
JT  - Frontiers in neural circuits
JID - 101477940
RN  - 0 (Biomarkers)
RN  - 0 (alpha-Synuclein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain Concussion/*blood/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/physiology/*physiopathology
MH  - Post-Concussion Syndrome/*blood
MH  - Young Adult
MH  - alpha-Synuclein/*blood
PMC - PMC6476917
OTO - NOTNLM
OT  - default mode network
OT  - functional connectivity
OT  - mild traumatic brain injury
OT  - rs-fMRI
OT  - alpha-synuclein
EDAT- 2019/05/02 06:00
MHDA- 2020/01/14 06:00
PMCR- 2019/01/01
CRDT- 2019/05/02 06:00
PHST- 2019/01/12 00:00 [received]
PHST- 2019/03/26 00:00 [accepted]
PHST- 2019/05/02 06:00 [entrez]
PHST- 2019/05/02 06:00 [pubmed]
PHST- 2020/01/14 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fncir.2019.00026 [doi]
PST - epublish
SO  - Front Neural Circuits. 2019 Apr 16;13:26. doi: 10.3389/fncir.2019.00026. 
      eCollection 2019.