PMID- 31041191
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 9
DP  - 2019
TI  - Pretreatment Level of Red Cell Distribution Width as a Prognostic Indicator for 
      Survival in a Large Cohort Study of Male Laryngeal Squamous Carcinoma.
PG  - 271
LID - 10.3389/fonc.2019.00271 [doi]
LID - 271
AB  - Objective: High levels of red cell distribution width (RDW) may be associated 
      with adverse outcomes in patients with cancer. The purpose of the present study 
      was to investigate the prognostic impact of pretreatment RDW levels on overall 
      survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS) in 
      a large cohort of male laryngeal squamous cell cancer (LSCC) patients. Methods: A 
      total of 809 LSCC patients who were treated between 2007 and 2011 at the Eye & 
      ENT Hospital of Fudan University were enrolled and evaluated retrospectively. OS, 
      CSS, and DFS were analyzed using the Kaplan-Meier method. To evaluate the 
      prognostic significance of RDW levels, univariate, and multivariate Cox analyses 
      were applied. Results: Higher pretreatment RDW levels were significantly 
      associated with high death events, red blood cell count, hemoglobin, 
      radiotherapy, operation therapy, and advanced tumor stage (p < 0.05). From the 
      univariate analysis, we observed that the higher (13.2-13.5%) and the highest 
      (>13.5%) quartiles of RDW level were consistent factors for poor OS, CSS, and DFS 
      in LSCC patients. In the multivariate analysis, after adjusting for confounding 
      factors, the higher and highest quartiles of RDW levels were identified as 
      independent prognostic factors in male LSCC patients. Conclusion: Higher 
      pretreatment RDW levels were demonstrated to be associated with poor clinical 
      outcome in male LSCC patients and might be novel markers for patient 
      stratification in LSCC management.
FAU - Hsueh, Chi-Yao
AU  - Hsueh CY
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, 
      Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, China.
FAU - Lau, Hui-Ching
AU  - Lau HC
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, 
      Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, China.
FAU - Li, Shengjie
AU  - Li S
AD  - Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, 
      Fudan University, Shanghai, China.
FAU - Tao, Lei
AU  - Tao L
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, 
      Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, China.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, 
      Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, China.
FAU - Gong, Hongli
AU  - Gong H
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, 
      Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - Department of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, 
      Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20190416
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC6477051
OTO - NOTNLM
OT  - biomarker
OT  - laryngeal squamous cell cancer
OT  - male
OT  - prognosis
OT  - red cell distribution width
EDAT- 2019/05/02 06:00
MHDA- 2019/05/02 06:01
PMCR- 2019/01/01
CRDT- 2019/05/02 06:00
PHST- 2018/12/12 00:00 [received]
PHST- 2019/03/25 00:00 [accepted]
PHST- 2019/05/02 06:00 [entrez]
PHST- 2019/05/02 06:00 [pubmed]
PHST- 2019/05/02 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2019.00271 [doi]
PST - epublish
SO  - Front Oncol. 2019 Apr 16;9:271. doi: 10.3389/fonc.2019.00271. eCollection 2019.