PMID- 31042638
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2213-2945 (Print)
IS  - 2213-2953 (Linking)
VI  - 6
IP  - 2
DP  - 2017 Mar-Apr
TI  - Sensitivity of fine-needle aspiration biopsy for diagnosing and grading 
      follicular lymphomas using a multiparameter approach in a cancer center.
PG  - 80-88
LID - S2213-2945(16)30426-4 [pii]
LID - 10.1016/j.jasc.2016.12.001 [doi]
AB  - OBJECTIVES: The diagnosis and grading of follicular lymphomas (FLs) by 
      fine-needle aspiration biopsy (FNAB) has not been systematically compared with 
      core needle biopsy (CNB). We evaluated the sensitivity of FNAB in diagnosing and 
      grading FLs using a multiparameter approach in a large cancer center. METHODS: We 
      retrospectively identified CNBs of lymph nodes diagnosed as FL that also had a 
      concurrently acquired FNAB on the same site. The majority of cases had flow 
      cytometric analysis and these results were available for interpretation of both 
      the FNAB and CNB. RESULTS: Out of 342 patients, CNB diagnoses included 291 (85%) 
      low-grade (LG) FLs, 30 (9%) high-grade (HG) FLs, and 21 (6%) non-graded 
      FLs/other. FNAB diagnoses included 194 (57%) LG FLs, 19 (6%) HG FLs, 93 (27%) 
      non-graded FLs, 9 (3%) large B-cell lymphomas (LBCL) of follicle center origin, 
      and 27 (7%) insufficient for diagnosis/other. Review of non-graded FLs showed 45% 
      LG, 35% indeterminate due to polymorphous lymphoid cells with increased numbers 
      of large cells, and 20% scant cellularity. Sensitivity of FNAB for diagnosing FL 
      was 89%, and 66% for LG FL. The latter increased (94%), however, when grading was 
      performed. CONCLUSION: FNAB is highly sensitive for diagnosing FLs when cellular 
      material for cytomorphology and flow cytometric analysis is obtained, and grading 
      is feasible for most LG FLs. A subset of FLs composed of a polymorphous lymphoid 
      population with increased numbers of large cells may be more difficult to grade, 
      and HG FLs can be difficult to distinguish from CD10-positive diffuse LBCLs.
CI  - Copyright (c) 2016 American Society of Cytopathology. Published by Elsevier Inc. 
      All rights reserved.
FAU - McCroskey, Zulfia
AU  - McCroskey Z
AD  - Section of Cytopathology, Department of Pathology, The University of Texas MD 
      Anderson Cancer Center, Houston, Texas.
FAU - Khoury, Joseph D
AU  - Khoury JD
AD  - Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 
      Houston, Texas.
FAU - Stewart, John M
AU  - Stewart JM
AD  - Section of Cytopathology, Department of Pathology, The University of Texas MD 
      Anderson Cancer Center, Houston, Texas.
FAU - Caraway, Nancy P
AU  - Caraway NP
AD  - Section of Cytopathology, Department of Pathology, The University of Texas MD 
      Anderson Cancer Center, Houston, Texas. Electronic address: 
      ncaraway@mdanderson.org.
LA  - eng
PT  - Journal Article
DEP - 20161223
PL  - United States
TA  - J Am Soc Cytopathol
JT  - Journal of the American Society of Cytopathology
JID - 101613234
OTO - NOTNLM
OT  - Core needle biopsy
OT  - Cytology
OT  - Fine-needle aspiration
OT  - Flow cytometry
OT  - Follicular lymphoma
OT  - Grading lymphomas
EDAT- 2017/01/01 00:00
MHDA- 2017/01/01 00:01
CRDT- 2019/05/03 06:00
PHST- 2016/11/10 00:00 [received]
PHST- 2016/12/14 00:00 [revised]
PHST- 2016/12/19 00:00 [accepted]
PHST- 2019/05/03 06:00 [entrez]
PHST- 2017/01/01 00:00 [pubmed]
PHST- 2017/01/01 00:01 [medline]
AID - S2213-2945(16)30426-4 [pii]
AID - 10.1016/j.jasc.2016.12.001 [doi]
PST - ppublish
SO  - J Am Soc Cytopathol. 2017 Mar-Apr;6(2):80-88. doi: 10.1016/j.jasc.2016.12.001. 
      Epub 2016 Dec 23.