PMID- 31043330
OWN - NLM
STAT- MEDLINE
DCOM- 20200113
LR  - 20200113
IS  - 1876-4754 (Electronic)
IS  - 1876-4754 (Linking)
VI  - 12
IP  - 5
DP  - 2019 Sep-Oct
TI  - Somatosensory-motor cortex interactions measured using dual-site transcranial 
      magnetic stimulation.
PG  - 1229-1243
LID - S1935-861X(19)30200-1 [pii]
LID - 10.1016/j.brs.2019.04.009 [doi]
AB  - BACKGROUND: Dual-site transcranial magnetic stimulation (ds-TMS) is a 
      neurophysiological technique to measure functional connectivity between cortical 
      areas. OBJECTIVE/HYPOTHESIS: To date, no study has used ds-TMS to investigate 
      short intra-hemispheric interactions between the somatosensory areas and primary 
      motor cortex (M1). METHODS: We examined somatosensory-M1 interactions in the left 
      hemisphere in six experiments using ds-TMS. In Experiment 1 (n = 16), the effects 
      of different conditioning stimulus (CS) intensities on somatosensory-M1 
      interactions were measured with 1 and 2.5 ms inter-stimulus intervals (ISIs). In 
      Experiment 2 (n = 16), the time-course of somatosensoy-M1 interactions was 
      studied using supra-threshold CS intensity at 6 different ISIs. In Experiment 3 
      (n = 16), the time-course of short-interval cortical inhibition (SICI) and 
      effects of different CS intensities on SICI were measured similar to Experiments 
      1 and 2. Experiment 4 (n = 13) examined the effects of active contraction on SICI 
      and somatosensory-M1 inhibition. Experiments 5 and 6 (n = 10) examined the 
      interactions between SAI with either 1 ms SICI or somatosensory-M1 inhibition. 
      RESULTS: Experiments 1 and 2 revealed reduced MEP amplitudes when applying 
      somatosensory CS 1 ms prior to M1 TS with 140 and 160% CS intensities. Experiment 
      3 demonstrated that SICI at 1 and 2.5 ms did not correlate with somatosensory-M1 
      inhibition. Experiment 4 found that SICI but not somatosensory-M1 inhibition was 
      abolished with active contraction. The results of Experiments 5-6 showed SAI was 
      disinhibited in presence of somatosensory-M1 while SAI was increased in presence 
      of SICI. CONCLUSION: Collectively, the results support the notion that the 
      somatosensory areas inhibit the ipsilateral M1 at very short latencies.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Brown, Matt J N
AU  - Brown MJN
AD  - Division of Brain, Imaging, & Behaviour - Systems Neuroscience, Krembil Brain 
      Institute, Toronto, Canada; Department of Kinesiology and Health Science, 
      California State University Sacramento, Sacramento, USA. Electronic address: 
      matt.brown@csus.edu.
FAU - Weissbach, Anne
AU  - Weissbach A
AD  - Division of Brain, Imaging, & Behaviour - Systems Neuroscience, Krembil Brain 
      Institute, Toronto, Canada; Institute of Neurogenetics, University of Lubeck, 
      Lubeck, Germany; Department of Neurology, University of Lubeck, Lubeck, Germany.
FAU - Pauly, Martje G
AU  - Pauly MG
AD  - Institute of Neurogenetics, University of Lubeck, Lubeck, Germany.
FAU - Vesia, Michael
AU  - Vesia M
AD  - Division of Brain, Imaging, & Behaviour - Systems Neuroscience, Krembil Brain 
      Institute, Toronto, Canada; School of Kinesiology, University of Michigan, Ann 
      Arbor, USA.
FAU - Gunraj, Carolyn
AU  - Gunraj C
AD  - Division of Brain, Imaging, & Behaviour - Systems Neuroscience, Krembil Brain 
      Institute, Toronto, Canada.
FAU - Baarbe, Julianne
AU  - Baarbe J
AD  - Division of Brain, Imaging, & Behaviour - Systems Neuroscience, Krembil Brain 
      Institute, Toronto, Canada; Division of Neurology, Department of Medicine, 
      University of Toronto, Toronto, Canada.
FAU - Munchau, Alexander
AU  - Munchau A
AD  - Institute of Neurogenetics, University of Lubeck, Lubeck, Germany.
FAU - Baumer, Tobias
AU  - Baumer T
AD  - Institute of Neurogenetics, University of Lubeck, Lubeck, Germany.
FAU - Chen, Robert
AU  - Chen R
AD  - Division of Brain, Imaging, & Behaviour - Systems Neuroscience, Krembil Brain 
      Institute, Toronto, Canada; Division of Neurology, Department of Medicine, 
      University of Toronto, Toronto, Canada.
LA  - eng
GR  - PDF 338973/CIHR/Canada
GR  - 357215/CIHR/Canada
GR  - FRN 154292/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190423
PL  - United States
TA  - Brain Stimul
JT  - Brain stimulation
JID - 101465726
SB  - IM
MH  - Adult
MH  - Electromyography/methods
MH  - Evoked Potentials, Motor/*physiology
MH  - Female
MH  - Functional Laterality/physiology
MH  - Humans
MH  - Male
MH  - Motor Cortex/*physiology
MH  - Neural Inhibition/*physiology
MH  - Somatosensory Cortex/*physiology
MH  - Transcranial Magnetic Stimulation/*methods
MH  - Young Adult
OTO - NOTNLM
OT  - Dual-site TMS
OT  - Motor
OT  - Paired-pulse TMS
OT  - Sensorimotor control
OT  - Somatosensory
OT  - TMS
EDAT- 2019/05/03 06:00
MHDA- 2020/01/14 06:00
CRDT- 2019/05/03 06:00
PHST- 2018/01/10 00:00 [received]
PHST- 2019/04/12 00:00 [revised]
PHST- 2019/04/16 00:00 [accepted]
PHST- 2019/05/03 06:00 [pubmed]
PHST- 2020/01/14 06:00 [medline]
PHST- 2019/05/03 06:00 [entrez]
AID - S1935-861X(19)30200-1 [pii]
AID - 10.1016/j.brs.2019.04.009 [doi]
PST - ppublish
SO  - Brain Stimul. 2019 Sep-Oct;12(5):1229-1243. doi: 10.1016/j.brs.2019.04.009. Epub 
      2019 Apr 23.