PMID- 31044730
OWN - NLM
STAT- MEDLINE
DCOM- 20200110
LR  - 20200110
IS  - 2468-6530 (Electronic)
IS  - 2468-6530 (Linking)
VI  - 3
IP  - 5
DP  - 2019 May
TI  - Multicolor Fundus Imaging of Polypoidal Choroidal Vasculopathy.
PG  - 400-409
LID - S2468-6530(18)30485-8 [pii]
LID - 10.1016/j.oret.2019.01.009 [doi]
AB  - PURPOSE: Polypoidal choroidal vasculopathy (PCV) is a variant of neovascular 
      age-related macular degeneration with distinct phenotypes, treatment, and visual 
      prognosis. Multicolor imaging is a novel noninvasive imaging method that enables 
      visualization of structures located at different layers of the retina and may be 
      useful in detecting features of diseases. The features of PCV seen on multicolor 
      imaging have not been studied. We aimed to describe the features of PCV detected 
      using multicolor imaging and to compare these with standard color fundus 
      photography (CFP). DESIGN: Hospital-based, cross-sectional study. PARTICIPANTS: 
      Fifty consecutive treatment-naive patients diagnosed with PCV seen in a tertiary 
      referral center. METHODS: Multimodal imaging was performed using standardized 
      protocols, and included CFP, multicolor imaging, fluorescein angiography, and 
      indocyanine green angiography (ICGA). The CFP and ICGA images were independently 
      graded by reading center-certified retinal specialists to confirm the diagnosis 
      of PCV and identify lesion components. The features of the lesion components seen 
      on multicolor images were compared with those detected using CFP and ICGA. MAIN 
      OUTCOME MEASURES: Frequency and features of lesions associated with PCV, 
      specifically, polyps, branching vascular network (BVN), pigment epithelial 
      detachments (PEDs), hemorrhages, and drusen. RESULTS: The mean age of the 50 
      participants was 67.9 years, and 60% were male. Polyps were most clearly seen on 
      the infrared reflectance image and detected in 49 of 50 eyes (98%), appearing as 
      dark gray oval lesions with distinct margins. On the multicolor composite images, 
      polyps appeared as dark green oval lesions. The BVN appeared as mottled gray 
      regions on infrared reflectance imaging and were seen less frequently compared 
      with polyps (30/50 eyes, 60%). The margins of the BVN were less distinct compared 
      with polyps. Other clinical features detected using multicolor imaging included 
      PEDs (26%), subretinal hemorrhages (40%), and drusen (66%). CONCLUSIONS: 
      Multicolor imaging is able to detect polypoidal lesions in most patients with 
      PCV. The appearance of PCV lesions on multicolor imaging differs from standard 
      CFP, although the location and shape of lesions correlate well with features seen 
      on CFP and ICGA. Multicolor imaging is a useful, noninvasive adjunct to detect 
      features suggestive of PCV, which may prompt definitive investigations such as 
      ICGA.
CI  - Copyright (c) 2019 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Tan, Colin S
AU  - Tan CS
AD  - Fundus Image Reading Centre, National Healthcare Group Eye Institute, Singapore; 
      National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore; 
      Duke-NUS Medical School, Singapore; Lee Kong Chian School of Medicine, Nanyang 
      Technological University, Singapore. Electronic address: 
      Colintan_eye@yahoo.com.sg.
FAU - Ting, Dominic S
AU  - Ting DS
AD  - National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore; Yong 
      Loo Lin School of Medicine, National University of Singapore, Singapore.
FAU - Lim, Louis W
AU  - Lim LW
AD  - National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190118
PL  - United States
TA  - Ophthalmol Retina
JT  - Ophthalmology. Retina
JID - 101695048
SB  - IM
MH  - Aged
MH  - Choroidal Neovascularization/diagnostic imaging/*pathology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fluorescein Angiography/methods
MH  - Fundus Oculi
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multimodal Imaging
MH  - Ophthalmoscopy/*methods
MH  - Photography/methods
MH  - Prospective Studies
EDAT- 2019/05/03 06:00
MHDA- 2020/01/11 06:00
CRDT- 2019/05/03 06:00
PHST- 2018/08/11 00:00 [received]
PHST- 2018/12/05 00:00 [revised]
PHST- 2019/01/09 00:00 [accepted]
PHST- 2019/05/03 06:00 [entrez]
PHST- 2019/05/03 06:00 [pubmed]
PHST- 2020/01/11 06:00 [medline]
AID - S2468-6530(18)30485-8 [pii]
AID - 10.1016/j.oret.2019.01.009 [doi]
PST - ppublish
SO  - Ophthalmol Retina. 2019 May;3(5):400-409. doi: 10.1016/j.oret.2019.01.009. Epub 
      2019 Jan 18.