PMID- 31045466
OWN - NLM
STAT- MEDLINE
DCOM- 20200529
LR  - 20200529
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 17
IP  - 6
DP  - 2019 Jul/Aug
TI  - Homocysteine Levels are Associated with Endothelial Function in Newly Diagnosed 
      Type 2 Diabetes Mellitus Patients.
PG  - 323-327
LID - 10.1089/met.2019.0011 [doi]
AB  - Background: Endothelial dysfunction is the earliest indicator of atherosclerosis. 
      Both type 2 diabetes mellitus (T2DM) and hyperhomocysteinemia (HHCY) are the risk 
      factors of endothelial dysfunction. However, the combined effect of T2DM and HHCY 
      on endothelial dysfunction is not clear. We investigated the endothelial function 
      in T2DM patients with HHCY in this study. Material and Methods: Fifty newly 
      diagnosed T2DM patients and 54 healthy subjects were recruited from Beijing 
      Chaoyang hospital. T2DM patients were divided into two subgroups as T2DM + NHCY 
      (n = 30) and T2DM + HHCY (n = 20) according to plasma homocysteine (HCY). HHCY 
      was defined as plasma HCY level higher than 15 mumol/L. Endothelial function was 
      measured by the reactive hyperemia index (RHI) with Endo PAT-2000. Results: Sex 
      and age were matched between T2DM group and healthy controls. T2DM group had 
      significantly higher HCY level (14.44 +/- 4.30 vs. 12.09 +/- 2.48 mmol/L, P < 0.05) 
      and lower RHI (1.73 +/- 0.50 vs. 2.05 +/- 0.49, P < 0.01) than controls. In the 
      subgroup analysis, T2DM with HHCY had significantly lower RHI than T2DM patients 
      without HHCY (1.53 +/- 0.20 vs. 1.86 +/- 0.59, P < 0.05). RHI was negatively 
      correlated with HCY (r = -0.325, P < 0.01), low-density lipoprotein cholesterol 
      (LDL-C) (r = -0.268, P < 0.01), HbA1c (r = -0.219, P < 0.05), and HOMA-IR 
      (r = -0.226, P < 0.05). Multiple linear regressions analysis was performed and 
      HCY, LDL-C, HbA1c, and HOMA-IR were entered in the model. Analysis showed that 
      HCY levels were independent negatively associated with RHI (beta = -0.032, 
      P < 0.05). Conclusions: T2DM patients with HHCY had poor endothelial function. 
      Serum HCY levels were negatively associated with RHI.
FAU - Hu, Yanjin
AU  - Hu Y
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Xu, Yuan
AU  - Xu Y
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Wang, Guang
AU  - Wang G
AD  - Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190502
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications/diagnosis/*physiopathology
MH  - Diabetic Angiopathies/*blood/etiology/physiopathology
MH  - Endothelium, Vascular/*physiology
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/complications/physiopathology
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - endothelial dysfunction
OT  - homocysteine
OT  - hyperhomocysteinemia
OT  - insulin resistance
OT  - type 2 diabetes
EDAT- 2019/05/03 06:00
MHDA- 2020/05/30 06:00
CRDT- 2019/05/03 06:00
PHST- 2019/05/03 06:00 [pubmed]
PHST- 2020/05/30 06:00 [medline]
PHST- 2019/05/03 06:00 [entrez]
AID - 10.1089/met.2019.0011 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2019 Jul/Aug;17(6):323-327. doi: 10.1089/met.2019.0011. 
      Epub 2019 May 2.