PMID- 31045779
OWN - NLM
STAT- MEDLINE
DCOM- 20190528
LR  - 20221207
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 18
DP  - 2019 May
TI  - Presence of diabetic retinopathy is lower in type 2 diabetic patients with 
      non-alcoholic fatty liver disease.
PG  - e15362
LID - 10.1097/MD.0000000000015362 [doi]
LID - e15362
AB  - To analyze the association between non-alcoholic fatty liver disease (NAFLD) and 
      the presence of diabetic retinopathy (DR) in patients with type 2 diabetes 
      mellitus (T2DM).Total 411 T2DM patients were divided into NAFLD and control 
      groups. NAFLD was diagnosed by ultrasound. Retinopathy was diagnosed by fundus 
      photography. All patients were screened based on medical history, physical 
      examinations, and laboratory measurements.The prevalence of NAFLD and DR in T2DM 
      patients was 60.8% and 40.9%, respectively. The presence of DR was associated 
      with diabetes duration, systolic blood pressure (SBP), glycated hemoglobin 
      (HbA1c), and proteinuria (all P < .001) using univariate and multivariate 
      regression analyses. The prevalence of DR was lower in patients with NAFLD than 
      those without NAFLD (37.2% vs 46.6%, P = .065), and significantly lower in 
      patients with moderate and severe NAFLD (30.2% vs 46.6%, P = .012; 14.3% vs 
      46.6%, P = .024). The presence of DR in NAFLD patients was associated with 
      diabetes duration (P = .032) in Chi-squared analysis.NAFLD and DR were highly 
      prevalent in T2DM patients. Diabetes duration, SBP, HbA1c, and proteinuria were 
      risk factors for DR in T2DM patients. The presence of DR was lower in T2DM 
      patients with NAFLD, which was mainly due to their shorter diabetes duration.
FAU - Zhang, Meng
AU  - Zhang M
AD  - Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing.
AD  - Department of Gastroenterology, Xian XD Group Hospital, Xi'an, Shaanxi Province, 
      China.
FAU - Li, Li
AU  - Li L
AD  - Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing.
FAU - Chen, Jing
AU  - Chen J
AD  - Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing.
FAU - Li, Bei
AU  - Li B
AD  - Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing.
FAU - Zhan, Yutao
AU  - Zhan Y
AD  - Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing.
FAU - Zhang, Chuan
AU  - Zhang C
AD  - Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Pressure
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Retinopathy/*epidemiology/*etiology
MH  - Female
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Non-alcoholic Fatty Liver Disease/*epidemiology
MH  - Prevalence
MH  - Proteinuria/epidemiology
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Time Factors
PMC - PMC6504314
COIS- The authors have no conflicts of interest to declare.
EDAT- 2019/05/03 06:00
MHDA- 2019/05/29 06:00
PMCR- 2019/05/03
CRDT- 2019/05/03 06:00
PHST- 2019/05/03 06:00 [entrez]
PHST- 2019/05/03 06:00 [pubmed]
PHST- 2019/05/29 06:00 [medline]
PHST- 2019/05/03 00:00 [pmc-release]
AID - 00005792-201905030-00024 [pii]
AID - MD-D-18-06581 [pii]
AID - 10.1097/MD.0000000000015362 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 May;98(18):e15362. doi: 10.1097/MD.0000000000015362.