PMID- 31046149
OWN - NLM
STAT- MEDLINE
DCOM- 20200727
LR  - 20200727
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 130
IP  - 2
DP  - 2020 Feb
TI  - Salvage open partial horizontal laryngectomy after failed radiotherapy: A 
      multicentric study.
PG  - 431-436
LID - 10.1002/lary.27959 [doi]
AB  - OBJECTIVES: The primary aim of the present study was to report our 
      multi-institutional experience in surgical salvage with open partial horizontal 
      laryngectomies (OPHL) after failed radiotherapy (RT) for laryngeal squamous cell 
      carcinoma (LSCC). Secondary aims were to analyze the prognostic meaning of the 
      main clinical and pathological parameters in relation to the oncologic outcome 
      and to compare our results with the available literature. STUDY DESIGN: A 
      retrospective multicenter analysis of surgical oncological outcomes. METHODS: We 
      retrospectively review the clinical charts of 70 recurrent LSCC patients after 
      primary RT failure undergone salvage OPHL. RESULTS: At last follow-up, 46 
      patients (65%) were disease-free; six (9%) were alive with disease; nine (12%) 
      died because of the disease; and nine (12%) died without evidence of disease. The 
      final local control, overall survival, disease-specific survival, and 
      laryngectomy-free survival were 87%, 75%, 87%, and 91%, respectively. Twelve 
      patients (17%) experienced postoperative complications, whereas 18 patients (25%) 
      experienced late sequelae. In five patients (7%), decannulation was not possible 
      because of postoperative laryngeal stenosis. CONCLUSION: In selected patients, 
      when proper selection criteria for conservation laryngeal surgery are adopted, 
      OPHL can be considered for salvage after RT failure. LEVEL OF EVIDENCE: 4 
      Laryngoscope, 130:431-436, 2020.
CI  - (c) 2019 The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Bertolin, Andy
AU  - Bertolin A
AD  - Otorhinolaryngology Service, Vittorio Veneto Hospital, Treviso, Italy.
FAU - Lionello, Marco
AU  - Lionello M
AUID- ORCID: 0000-0002-2454-9618
AD  - Otorhinolaryngology Service, Vittorio Veneto Hospital, Treviso, Italy.
FAU - Ghizzo, Marco
AU  - Ghizzo M
AD  - Otorhinolaryngology Service, Vittorio Veneto Hospital, Treviso, Italy.
FAU - Cena, Isida
AU  - Cena I
AD  - Otorhinolaryngology Service, Vittorio Veneto Hospital, Treviso, Italy.
FAU - Leone, Federico
AU  - Leone F
AD  - Humanitas San Pio X Hospital, Milan, Italy.
FAU - Valerini, Sara
AU  - Valerini S
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Modena and 
      Reggio Emilia, Policlinico di Modena, Modena, Italy.
FAU - Mattioli, Francesco
AU  - Mattioli F
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Modena and 
      Reggio Emilia, Policlinico di Modena, Modena, Italy.
FAU - Crosetti, Erika
AU  - Crosetti E
AUID- ORCID: 0000-0003-4340-9677
AD  - Head Neck Oncology Unit Candiolo Cancer Institute-FPO IRCCS, Candiolo, Italy.
FAU - Presutti, Livio
AU  - Presutti L
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Modena and 
      Reggio Emilia, Policlinico di Modena, Modena, Italy.
FAU - Succo, Giovanni
AU  - Succo G
AD  - Head Neck Oncology Unit Candiolo Cancer Institute-FPO IRCCS, Candiolo, Italy.
AD  - Department of Oncology, University of Turin, Orbassano, Italy.
FAU - Rizzotto, Giuseppe
AU  - Rizzotto G
AD  - Otorhinolaryngology Service, Vittorio Veneto Hospital, Treviso, Italy.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20190502
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Carcinoma, Squamous Cell/diagnostic imaging/radiotherapy/*surgery
MH  - Female
MH  - Humans
MH  - Italy
MH  - Laryngeal Neoplasms/diagnostic imaging/radiotherapy/*surgery
MH  - Laryngectomy/*methods
MH  - Male
MH  - Middle Aged
MH  - Neck Dissection
MH  - Neoplasm Recurrence, Local
MH  - Patient Selection
MH  - Prognosis
MH  - Retrospective Studies
MH  - *Salvage Therapy
OTO - NOTNLM
OT  - OPHL
OT  - RT
OT  - laryngeal carcinoma
OT  - recurrence
OT  - salvage
EDAT- 2019/05/03 06:00
MHDA- 2020/07/28 06:00
CRDT- 2019/05/03 06:00
PHST- 2019/02/07 00:00 [received]
PHST- 2019/03/01 00:00 [revised]
PHST- 2019/03/11 00:00 [accepted]
PHST- 2019/05/03 06:00 [pubmed]
PHST- 2020/07/28 06:00 [medline]
PHST- 2019/05/03 06:00 [entrez]
AID - 10.1002/lary.27959 [doi]
PST - ppublish
SO  - Laryngoscope. 2020 Feb;130(2):431-436. doi: 10.1002/lary.27959. Epub 2019 May 2.