PMID- 3104710
OWN - NLM
STAT- MEDLINE
DCOM- 19870427
LR  - 20190701
IS  - 0024-3205 (Print)
IS  - 0024-3205 (Linking)
VI  - 40
IP  - 13
DP  - 1987 Mar 30
TI  - The involvement of central cholinergic mechanisms in cardiovascular responses to 
      intracerebroventricular and intravenous administration of thyrotropin-releasing 
      hormone.
PG  - 1293-9
AB  - Intracerebroventricular (i.c.v.) administration of thyrotropin-releasing hormone 
      (TRH) in a range from 0.1 to 100 micrograms induced a dose-related increase in 
      blood pressure in conscious rats, whereas TRH-free acid (TRH-OH) and 
      histidyl-proline diketopiperazine (His-Pro-DKP), metabolites of TRH, did not. The 
      blood pressure responses to intravenous (i.v.) injection of 5 mg/Kg TRH were 
      similar to those induced by TRH (i.c.v.). Pretreatment with atropine (50 
      micrograms, i.c.v.) significantly reduced the pressor effect of TRH administered 
      through either route. Hemicholinium-3 (50 micrograms, i.c.v.), an inhibitor of 
      choline uptake, also prevented the increase in blood pressure induced by TRH (10 
      micrograms, i.c.v.). These results indicate that both centrally and peripherally 
      administered TRH have pressor effects that are mediated by central cholinergic 
      mechanisms, probably by activating cholinergic neurons.
FAU - Okuda, C
AU  - Okuda C
FAU - Mizobe, T
AU  - Mizobe T
FAU - Miyazaki, M
AU  - Miyazaki M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Peptides, Cyclic)
RN  - 0 (Piperazines)
RN  - 24769-58-2 (thyrotropin-releasing hormone, deamido-)
RN  - 312-45-8 (Hemicholinium 3)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - 6EE945D3OK (Mecamylamine)
RN  - 7C0697DR9I (Atropine)
RN  - Q10817UXVT (histidyl-proline diketopiperazine)
RN  - SZB83O1W42 (Pyrrolidonecarboxylic Acid)
SB  - IM
MH  - Animals
MH  - Atropine/pharmacology
MH  - Blood Pressure/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Heart Rate/drug effects
MH  - Hemicholinium 3/pharmacology
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Male
MH  - Mecamylamine/pharmacology
MH  - Peptides, Cyclic/pharmacology
MH  - Piperazines/pharmacology
MH  - Pyrrolidonecarboxylic Acid/analogs & derivatives
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Thyrotropin-Releasing Hormone/administration & dosage/analogs & 
      derivatives/antagonists & inhibitors/*pharmacology
EDAT- 1987/03/30 00:00
MHDA- 1987/03/30 00:01
CRDT- 1987/03/30 00:00
PHST- 1987/03/30 00:00 [pubmed]
PHST- 1987/03/30 00:01 [medline]
PHST- 1987/03/30 00:00 [entrez]
AID - 0024-3205(87)90586-8 [pii]
AID - 10.1016/0024-3205(87)90586-8 [doi]
PST - ppublish
SO  - Life Sci. 1987 Mar 30;40(13):1293-9. doi: 10.1016/0024-3205(87)90586-8.