PMID- 31047777
OWN - NLM
STAT- MEDLINE
DCOM- 20200915
LR  - 20200915
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 33
IP  - 7
DP  - 2019 Jul
TI  - The association between serum uric acid to creatinine ratio and renal disease 
      progression in type 2 diabetic patients in Chinese communities.
PG  - 473-476
LID - S1056-8727(18)30745-1 [pii]
LID - 10.1016/j.jdiacomp.2018.10.013 [doi]
AB  - AIMS: Serum uric acid (UA) increases in patients with kidney disease due to the 
      impaired UA clearance. The present study sought to evaluate the association 
      between UA/creatinine ratio (UA/Cr) and renal disease progression in patients 
      with type 2 diabetes mellitus (T2DM) in Chinese communities. METHODS: In the 
      present retrospective longitudinal study, 3432 Chinese T2DM patients recruited 
      from 11 community healthcare centers in Nanjing, China were included. Renal 
      disease progression was defined as the occurrence of estimated glomerular 
      filtration rate (eGFR) <15 mL/min/1.73 m(2) or doubling of baseline serum 
      creatinine level. Cox regression analysis was used to estimate the association 
      between UA/Cr and renal disease progression. RESULTS: During a median follow-up 
      of 30 months, 58 (1.70%) patients experienced progression of renal disease, which 
      was more common among those with older ages, longer diabetes duration, and higher 
      baseline eGFR. Multivariate analysis revealed that UA/Cr was an independent risk 
      factor for renal disease progress (hazard ratio 1.364 [95% CI 1.131-1.646], 
      P = 0.001) independently of age, sex, and other potential confounders. 
      CONCLUSIONS: UA/Cr might be a novel predictor of chronic kidney disease 
      progression in T2DM patients.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Chunlei, Yao
AU  - Chunlei Y
AD  - Department of Nephrology, The First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital, Jiangsu, China; Department of Nephrology, 
      Tai zhou NO.2 People's Hospital, Tai zhou, Jiangsu, China.
FAU - Liubao, Gu
AU  - Liubao G
AD  - Department of Endocrinology and Metabolism, Jiangsu Province Official Hospital, 
      Nanjing, China.
FAU - Tao, Wang
AU  - Tao W
AD  - Department of Nephrology, Tai zhou NO.2 People's Hospital, Tai zhou, Jiangsu, 
      China.
FAU - Changying, Xing
AU  - Changying X
AD  - Department of Nephrology, The First Affiliated Hospital of Nanjing Medical 
      University, Jiangsu Province Hospital, Jiangsu, China. Electronic address: 
      cyxing62@126.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20181103
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 268B43MJ25 (Uric Acid)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - China
MH  - Creatinine/*blood
MH  - Diabetes Mellitus, Type 2/*blood/complications/pathology
MH  - Diabetic Nephropathies/blood/*pathology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Renal Insufficiency, Chronic/blood/*pathology
MH  - Retrospective Studies
MH  - Uric Acid/*blood
OTO - NOTNLM
OT  - Chinese
OT  - Renal disease progress
OT  - Risk factor
OT  - Type 2 diabetes mellitus
OT  - Uric acid
EDAT- 2019/05/03 06:00
MHDA- 2020/09/17 06:00
CRDT- 2019/05/04 06:00
PHST- 2018/07/19 00:00 [received]
PHST- 2018/09/27 00:00 [revised]
PHST- 2018/10/20 00:00 [accepted]
PHST- 2019/05/03 06:00 [pubmed]
PHST- 2020/09/17 06:00 [medline]
PHST- 2019/05/04 06:00 [entrez]
AID - S1056-8727(18)30745-1 [pii]
AID - 10.1016/j.jdiacomp.2018.10.013 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2019 Jul;33(7):473-476. doi: 
      10.1016/j.jdiacomp.2018.10.013. Epub 2018 Nov 3.