PMID- 31049195
OWN - NLM
STAT- MEDLINE
DCOM- 20200122
LR  - 20200309
IS  - 2045-709X (Electronic)
IS  - 2045-709X (Linking)
VI  - 27
DP  - 2019
TI  - How big is the effect of spinal manipulation on the pressure pain threshold and 
      for how long does it last? - secondary analysis of data from a systematic review.
PG  - 22
LID - 10.1186/s12998-019-0240-4 [doi]
LID - 22
AB  - BACKGROUND: Spinal manipulation (SM) has been shown in a systematic review to 
      have a statistically significant effect on the pressure pain threshold (PPT) in 
      asymptomatic subjects, when SM is compared to a sham intervention. The magnitude 
      and duration of this effect is unclear. OBJECTIVES: To determine the effect-size 
      of SM in asymptomatic subjects and its duration. METHOD: This is a secondary 
      analysis of data from a previous review. We sought to compare the effect-sizes in 
      the various articles but had to calculate them ourselves, at different follow-up 
      time measurements. Effect-sizes (Cohen's d or Hedge's g coefficient) were 
      considered low, medium, and large, at the cut points of 0.2, 0.5, and 0.8, 
      respectively. RESULTS: Effect-sizes were reported in 6/8 studies, but all had 
      calculated 'within-group' changes, not 'between-group' differences. Immediately 
      after SM, only one study of four (with four measurements) had a statistically 
      significant 'medium' effect size (d = 0.56; 95% CI: 00.4-1.08 to d = 0.70; 95% 
      CI:0.18-1.22). Five minutes after SM, 4/5 studies found a statistically 
      significant 'medium to large' effect-size (d = 0.51; 95% CI: 0.04-0.98 to 
      d = 1.24; 95% CI: 0.28-2.20). Ten minutes after SM, two studies reported a 
      'medium' effect-size with statistical significance (d = 0.58; 95% CI: 0.11-1.05 
      to d = 0.80; 95% CI: 0.12-1.48). We drew no conclusions for the effect-sizes at 
      one minute and thirty minutes after SM, as no between-group statistical 
      difference was found. CONCLUSION: Authors need to revise their approach to 
      'effect size'. Our calculations showed that the effect-size of SM on PPT may go 
      from 'medium' to 'large' within the first five minutes but appears to diminish 
      again within ten minutes. Research of this type should collect information for 
      longer periods and compare results to other interventions to put results into 
      perspective.
FAU - Honore, Margaux
AU  - Honore M
AUID- ORCID: 0000-0003-3462-5781
AD  - 1CIAMS, University of Paris-Sud, University of Paris-Saclay, F-91405 Orsay Cedex, 
      France.
AD  - 2CIAMS, University of Orleans, F-45067 Orleans, France.
AD  - Institut Franco Europeen de Chiropraxie, 24 boulevard Paul Vaillant-Couturier, 
      F-94200 Ivry sur Seine, France.
FAU - Leboeuf-Yde, Charlotte
AU  - Leboeuf-Yde C
AD  - 1CIAMS, University of Paris-Sud, University of Paris-Saclay, F-91405 Orsay Cedex, 
      France.
AD  - 2CIAMS, University of Orleans, F-45067 Orleans, France.
AD  - Institut Franco Europeen de Chiropraxie, 24 boulevard Paul Vaillant-Couturier, 
      F-94200 Ivry sur Seine, France.
AD  - 4University of Southern Denmark, Institute for Regional Health Research, Odense, 
      Denmark.
FAU - Gagey, Olivier
AU  - Gagey O
AD  - 1CIAMS, University of Paris-Sud, University of Paris-Saclay, F-91405 Orsay Cedex, 
      France.
AD  - 2CIAMS, University of Orleans, F-45067 Orleans, France.
FAU - Wedderkopp, Niels
AU  - Wedderkopp N
AD  - 4University of Southern Denmark, Institute for Regional Health Research, Odense, 
      Denmark.
AD  - 5Orthopedic Department, Hospital of Southwestern Jutland, Esbjerg, Denmark.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20190424
PL  - England
TA  - Chiropr Man Therap
JT  - Chiropractic & manual therapies
JID - 101551481
SB  - IM
MH  - Humans
MH  - *Manipulation, Spinal
MH  - *Pain Management
MH  - Pain Threshold
MH  - Randomized Controlled Trials as Topic
MH  - Time Factors
PMC - PMC6480891
OTO - NOTNLM
OT  - Asymptomatic subjects
OT  - Duration
OT  - Effect size
OT  - Pressure pain threshold
OT  - Spinal manipulation
COIS- Not applicable.Not applicable.The authors report that they have no competing 
      interests.Springer Nature remains neutral with regard to jurisdictional claims in 
      published maps and institutional affiliations.
EDAT- 2019/05/03 06:00
MHDA- 2020/01/23 06:00
PMCR- 2019/04/24
CRDT- 2019/05/04 06:00
PHST- 2018/12/12 00:00 [received]
PHST- 2019/02/25 00:00 [accepted]
PHST- 2019/05/04 06:00 [entrez]
PHST- 2019/05/03 06:00 [pubmed]
PHST- 2020/01/23 06:00 [medline]
PHST- 2019/04/24 00:00 [pmc-release]
AID - 240 [pii]
AID - 10.1186/s12998-019-0240-4 [doi]
PST - epublish
SO  - Chiropr Man Therap. 2019 Apr 24;27:22. doi: 10.1186/s12998-019-0240-4. 
      eCollection 2019.