PMID- 31052382
OWN - NLM
STAT- MEDLINE
DCOM- 20190812
LR  - 20200225
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 9
DP  - 2019 May 1
TI  - Dendritic Cell-Mediated Th2 Immunity and Immune Disorders.
LID - 10.3390/ijms20092159 [doi]
LID - 2159
AB  - Dendritic cells (DCs) are the professional antigen-presenting cells that 
      recognize and present antigens to naive T cells to induce antigen-specific 
      adaptive immunity. Among the T-cell subsets, T helper type 2 (Th2) cells produce 
      the humoral immune responses required for protection against helminthic disease 
      by activating B cells. DCs induce a Th2 immune response at a certain immune 
      environment. Basophil, eosinophil, mast cells, and type 2 innate lymphoid cells 
      also induce Th2 immunity. However, in the case of DCs, controversy remains 
      regarding which subsets of DCs induce Th2 immunity, which genes in DCs are 
      directly or indirectly involved in inducing Th2 immunity, and the detailed 
      mechanisms underlying induction, regulation, or maintenance of the DC-mediated 
      Th2 immunity against allergic environments and parasite infection. A recent study 
      has shown that a genetic defect in DCs causes an enhanced Th2 immunity leading to 
      severe atopic dermatitis. We summarize the Th2 immune-inducing DC subsets, the 
      genetic and environmental factors involved in DC-mediated Th2 immunity, and 
      current therapeutic approaches for Th2-mediated immune disorders. This review is 
      to provide an improved understanding of DC-mediated Th2 immunity and Th1/Th2 
      immune balancing, leading to control over their adverse consequences.
FAU - Kumar, Sunil
AU  - Kumar S
AD  - Science Research Center (SRC) for Immune Research on Non-Lymphoid Organ (CIRNO), 
      Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, Korea. 
      sunilkumar@skku.edu.
FAU - Jeong, Yideul
AU  - Jeong Y
AD  - Science Research Center (SRC) for Immune Research on Non-Lymphoid Organ (CIRNO), 
      Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, Korea. 
      skyiller@gmail.com.
AD  - Department of Biological Sciences, Sungkyunkwan University, Jangan-gu, Suwon, 
      Gyeonggi-do 16419, Korea. skyiller@gmail.com.
FAU - Ashraf, Muhammad Umer
AU  - Ashraf MU
AD  - Science Research Center (SRC) for Immune Research on Non-Lymphoid Organ (CIRNO), 
      Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, Korea. 
      drumerashraf@gmail.com.
AD  - Department of Biological Sciences, Sungkyunkwan University, Jangan-gu, Suwon, 
      Gyeonggi-do 16419, Korea. drumerashraf@gmail.com.
FAU - Bae, Yong-Soo
AU  - Bae YS
AD  - Science Research Center (SRC) for Immune Research on Non-Lymphoid Organ (CIRNO), 
      Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, Korea. 
      ysbae04@skku.edu.
AD  - Department of Biological Sciences, Sungkyunkwan University, Jangan-gu, Suwon, 
      Gyeonggi-do 16419, Korea. ysbae04@skku.edu.
LA  - eng
GR  - SRC-2017R1A5A1014560/National Research Foundation of Korea/
GR  - HI16C1074/Korea Health Industry Development Institute/Republic of Korea
GR  - 2018R1D1A1B07048567/National Research Foundation of Korea/
PT  - Journal Article
PT  - Review
DEP - 20190501
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune System Diseases/*immunology/therapy
MH  - Immunotherapy/methods
MH  - Th2 Cells/*immunology
PMC - PMC6539046
OTO - NOTNLM
OT  - Th2 disorders
OT  - Th2 immunity
OT  - dendritic cells
OT  - environmental factors
OT  - genetic factors
OT  - therapeutic approaches
COIS- The authors have no conflicts of interest to declare. The funders had no role in 
      the design of the study or in the writing of the manuscript.
EDAT- 2019/05/06 06:00
MHDA- 2019/08/14 06:00
PMCR- 2019/05/01
CRDT- 2019/05/05 06:00
PHST- 2019/03/30 00:00 [received]
PHST- 2019/04/29 00:00 [revised]
PHST- 2019/04/29 00:00 [accepted]
PHST- 2019/05/05 06:00 [entrez]
PHST- 2019/05/06 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - ijms20092159 [pii]
AID - ijms-20-02159 [pii]
AID - 10.3390/ijms20092159 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 May 1;20(9):2159. doi: 10.3390/ijms20092159.