PMID- 31053482
OWN - NLM
STAT- MEDLINE
DCOM- 20201029
LR  - 20201029
IS  - 1878-4046 (Electronic)
IS  - 1076-6332 (Linking)
VI  - 27
IP  - 2
DP  - 2020 Feb
TI  - Assessment of Myocardial Viability in Ischemic Heart Disease by PET/MRI: 
      Comparison of Left Ventricular Perfusion, Hibernation, and Scar Burden.
PG  - 188-197
LID - S1076-6332(19)30180-1 [pii]
LID - 10.1016/j.acra.2019.03.021 [doi]
AB  - RATIONALE AND OBJECTIVES: Hybrid positron emission tomography-magnetic resonance 
      (PET-MR) is a novel imaging technology that enables a comprehensive assessment of 
      myocardial viability. The aim of this study was to intra-individually compare 
      simultaneously acquired viability parameters from MRI and PET to determine 
      complementary and redundant information. MATERIALS AND METHODS: Thirty-nine 
      patients with ischemic heart disease (IHD) underwent cardiac PET-MR for 
      myocardial viability assessment. Cardiac magnetic resonance (CMR), including late 
      gadolinium enhancement (LGE), and PET, including a dynamic dual-tracer 
      acquisition of [(13)N]ammonia ([(13)N]NH(3))/[(18)F]fluorodeoxyglucose 
      ([(18)F]FDG), were performed simultaneously. Allocation, extent, and transmural 
      degree of left ventricular (LV) scars were measured from LGE. Perfusion, 
      viability, and hibernation were assessed by PET. RESULTS: A comparison of scar 
      location revealed six more areas of infarction on MR than on PET. Mean LV 
      scarring by CMR was 14% (range, 2% to 42%) and 14% (range, 1% to 46%) by PET (CMR 
      vs. PET: p = 0.9). An intra-individual comparison of scarring showed a good 
      inter-method correlation (r = 0.7), which was also evident in the subgroup with 
      low ejection fraction (EF) (r = 0.6). Hibernation and transmural degree of scars 
      showed a moderate to weak correlation (r = 0.4), which was even worse in the low 
      EF group (r = 0.1). CONCLUSIONS: In patients with IHD, there was a good 
      correlation between PET and CMR for the LV scar extent using hybrid cardiac 
      PET-MR. The degree of transmural scarring by CMR showed no correlation to PET 
      hibernation. Therefore, cardiac PET-MR might be a suitable tool for a 
      comprehensive assessment of myocardial viability if used to predict response to 
      cardiac reperfusion strategies.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Beitzke, Dietrich
AU  - Beitzke D
AD  - Department of Biomedical Imaging and Image-Guided Therapy, Division of 
      Cardiovascular and Interventional Radiology, Medical University of Vienna, 
      Vienna, Austria.
FAU - Rasul, Sazan
AU  - Rasul S
AD  - Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear 
      Medicine, Medical University of Vienna, Waehringer Gurtel 18-20, 1090 Vienna, 
      Austria.
FAU - Lassen, Martin Lyngby
AU  - Lassen ML
AD  - QIMP Group, Center for Medical Physics and Biomedical Engineering, Medical 
      University of Vienna, Vienna, Austria.
FAU - Pichler, Verena
AU  - Pichler V
AD  - Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear 
      Medicine, Medical University of Vienna, Waehringer Gurtel 18-20, 1090 Vienna, 
      Austria.
FAU - Senn, Daniela
AU  - Senn D
AD  - Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear 
      Medicine, Medical University of Vienna, Waehringer Gurtel 18-20, 1090 Vienna, 
      Austria.
FAU - Stelzmuller, Marie Elisabeth
AU  - Stelzmuller ME
AD  - Department of Surgery, Division of Cardiac Surgery, Medical University of Vienna, 
      Vienna, Austria.
FAU - Nolz, Richard
AU  - Nolz R
AD  - Department of Biomedical Imaging and Image-Guided Therapy, Division of 
      Cardiovascular and Interventional Radiology, Medical University of Vienna, 
      Vienna, Austria.
FAU - Loewe, Christian
AU  - Loewe C
AD  - Department of Biomedical Imaging and Image-Guided Therapy, Division of 
      Cardiovascular and Interventional Radiology, Medical University of Vienna, 
      Vienna, Austria.
FAU - Hacker, Marcus
AU  - Hacker M
AD  - Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear 
      Medicine, Medical University of Vienna, Waehringer Gurtel 18-20, 1090 Vienna, 
      Austria. Electronic address: marcus.hacker@meduniwien.ac.at.
LA  - eng
PT  - Journal Article
DEP - 20190430
PL  - United States
TA  - Acad Radiol
JT  - Academic radiology
JID - 9440159
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - *Cicatrix/diagnostic imaging
MH  - Contrast Media
MH  - Gadolinium
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - *Myocardial Ischemia/diagnostic imaging
MH  - Positron-Emission Tomography
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Myocardial ischemia
OT  - Myocardium
OT  - hybrid imaging
OT  - magnetic resonance imaging
OT  - myocardial stunning
EDAT- 2019/05/06 06:00
MHDA- 2020/10/30 06:00
CRDT- 2019/05/05 06:00
PHST- 2018/10/18 00:00 [received]
PHST- 2019/03/08 00:00 [revised]
PHST- 2019/03/24 00:00 [accepted]
PHST- 2019/05/06 06:00 [pubmed]
PHST- 2020/10/30 06:00 [medline]
PHST- 2019/05/05 06:00 [entrez]
AID - S1076-6332(19)30180-1 [pii]
AID - 10.1016/j.acra.2019.03.021 [doi]
PST - ppublish
SO  - Acad Radiol. 2020 Feb;27(2):188-197. doi: 10.1016/j.acra.2019.03.021. Epub 2019 
      Apr 30.