PMID- 31054113
OWN - NLM
STAT- MEDLINE
DCOM- 20190813
LR  - 20200309
IS  - 1179-1969 (Electronic)
IS  - 1170-229X (Linking)
VI  - 36
IP  - 7
DP  - 2019 Jul
TI  - Relative Risk of Adverse Events and Treatment Discontinuations Between Older and 
      Non-Older Adults Treated with Antimuscarinics for Overactive Bladder: A 
      Systematic Review and Meta-Analysis.
PG  - 639-645
LID - 10.1007/s40266-019-00674-9 [doi]
AB  - INTRODUCTION: Overactive bladder (OAB) affects adults of all ages. The risk for 
      medication-related adverse events (AEs) may differ between age groups, given 
      age-related changes in pharmacokinetics and pharmacodynamics. No previous study 
      has differentiated the risk of AEs between older and non-older adults with OAB. 
      OBJECTIVE: Our objective was to assess the risk of AEs and treatment 
      discontinuations between older and non-older adults with OAB initiated on an 
      antimuscarinic. METHODS: We searched MEDLINE (PubMed interface), Embase, SCOPUS, 
      and Cochrane Central Register for Controlled Trials in a previous analysis in 
      February 2015 and repeated the search in August 2018, with no additional studies 
      identified. Studies that delineated AEs or treatment discontinuations between the 
      older and non-older (age <65 years) subjects were included. RESULTS: Six studies 
      that made nine comparisons between older and non-older subjects met the inclusion 
      criteria. The AEs of dry mouth (46.7%), constipation (10.3%), and headache (7.7%) 
      were most frequently reported. Older subjects were more likely to experience dry 
      mouth (relative risk [RR] 1.09; 95% confidence interval [CI] 1.00-1.19), 
      constipation (RR 1.92; 95% CI 1.52-2.43), dizziness (RR 2.37; 95% CI 1.21-4.62), 
      and urinary retention (RR 4.17; 95% CI 1.76-9.89) than were non-older subjects. 
      Headache was less likely to occur in older subjects (RR 0.58; 95% CI 0.40-0.86). 
      Treatment discontinuations due to AEs were more likely to occur in the older 
      subjects (RR 1.59; 95% CI 1.20-2.11). CONCLUSION: Treatment of OAB with 
      antimuscarinics in the older population resulted in significantly higher rates of 
      AEs, barring headache, when compared with non-older subjects.
FAU - Usmani, Silken A
AU  - Usmani SA
AD  - College of Pharmacy, University of Florida, PO Box 100496, Gainesville, FL, 
      32610, USA.
FAU - Reckenberg, Kristine
AU  - Reckenberg K
AD  - College of Pharmacy, St. Louis County Department of Public Health, St. Louis, MO, 
      USA.
FAU - Johnson, Olivia
AU  - Johnson O
AD  - Walmart Neighborhood Market, Mansfield, TX, USA.
FAU - Stranges, Paul M
AU  - Stranges PM
AD  - College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
FAU - Teshome, Besu F
AU  - Teshome BF
AD  - St. Louis College of Pharmacy, St. Louis, MO, USA.
FAU - Kebodeaux, Clark D
AU  - Kebodeaux CD
AD  - College of Pharmacy, University of Kentucky, Lexington, KY, USA.
FAU - Vouri, Scott Martin
AU  - Vouri SM
AUID- ORCID: 0000-0002-0411-2160
AD  - College of Pharmacy, University of Florida, PO Box 100496, Gainesville, FL, 
      32610, USA. SVouri@cop.ufl.edu.
AD  - Center for Drug Evaluation and Safety, University of Florida, Gainesville, FL, 
      USA. SVouri@cop.ufl.edu.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - New Zealand
TA  - Drugs Aging
JT  - Drugs & aging
JID - 9102074
RN  - 0 (Muscarinic Antagonists)
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Constipation/chemically induced
MH  - Headache/chemically induced
MH  - Humans
MH  - Muscarinic Antagonists/*administration & dosage/*adverse effects
MH  - Randomized Controlled Trials as Topic
MH  - Risk
MH  - Urinary Bladder, Overactive/*drug therapy
MH  - Xerostomia/chemically induced
EDAT- 2019/05/06 06:00
MHDA- 2019/08/14 06:00
CRDT- 2019/05/05 06:00
PHST- 2019/05/06 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
PHST- 2019/05/05 06:00 [entrez]
AID - 10.1007/s40266-019-00674-9 [pii]
AID - 10.1007/s40266-019-00674-9 [doi]
PST - ppublish
SO  - Drugs Aging. 2019 Jul;36(7):639-645. doi: 10.1007/s40266-019-00674-9.