PMID- 3105460
OWN - NLM
STAT- MEDLINE
DCOM- 19870427
LR  - 20131121
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 14
IP  - 3 Pt 2
DP  - 1987 Mar
TI  - [Research related to hormones in Nagase analbuminemic rats].
PG  - 763-70
AB  - The levels of hormones in the anterior pituitary gland and serum in Nagase 
      analbuminemic rats (NAR) were examined. For the anterior pituitary gland, the 
      contents of prolactin, TSH, GH, LH and FSH in male NAR were lower than those of 
      normal rats. In female NAR, prolactin and TSH levels were also lower than those 
      in normal rats, whereas LH, FSH and GH were unchanged. In serum, the 
      concentrations of TSH, T3, T4, estradiol, testosterone and prolactin (female 
      only) were examined. The serum prolactin level in female NAR was lower than that 
      of normal rats, whereas a higher level of serum TSH was seen in NAR. Male NAR had 
      a higher T3 level and a lower T4 level. Although the estradiol concentration in 
      male NAR was normal, the serum testosterone level was only a quarter of that in 
      normal rats. We investigated the reason for the low level of serum testosterone 
      in male NAR through biochemical studies on steroid metabolism. The results 
      indicated that the low serum concentration of testosterone in NAR was mainly 
      attributable to decreased biosynthesis of testosterone in the testes. Prolactin 
      is the primary hormone for experimental mammary tumorigenesis. In association 
      with the lower prolactin level in female NAR, induction of tumors by 7, 
      12-dimethylbenz (a) anthracene (DMBA) was studied. NAR showed a significantly 
      lower mammary tumor response to DMBA. The incidences of spontaneous mammary tumor 
      in NAR and normal rats after 2 years were also compared. The incidence was much 
      lower in NAR than in the controls. Thus the lower mammary tumor induction in NAR 
      could mostly be ascribed to the lower level of circulating prolactin.
FAU - Nagase, S
AU  - Nagase S
FAU - Takahashi, M
AU  - Takahashi M
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
RN  - 0 (Pituitary Hormones, Anterior)
RN  - 0 (Serum Albumin)
RN  - 3XMK78S47O (Testosterone)
RN  - 4TI98Z838E (Estradiol)
RN  - 57-97-6 (9,10-Dimethyl-1,2-benzanthracene)
RN  - 9002-71-5 (Thyrotropin)
SB  - IM
MH  - 9,10-Dimethyl-1,2-benzanthracene
MH  - Animals
MH  - Estradiol/blood
MH  - Female
MH  - Male
MH  - Mammary Neoplasms, Experimental/*blood/chemically induced
MH  - Pituitary Hormones, Anterior/*blood
MH  - Rats
MH  - Rats, Mutant Strains
MH  - Serum Albumin/*deficiency
MH  - Testosterone/*blood
MH  - Thyrotropin/blood
EDAT- 1987/03/01 00:00
MHDA- 1987/03/01 00:01
CRDT- 1987/03/01 00:00
PHST- 1987/03/01 00:00 [pubmed]
PHST- 1987/03/01 00:01 [medline]
PHST- 1987/03/01 00:00 [entrez]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 1987 Mar;14(3 Pt 2):763-70.