PMID- 31055052
OWN - NLM
STAT- MEDLINE
DCOM- 20200313
LR  - 20200313
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 87
DP  - 2019 Aug
TI  - Reproductive evaluations in female rat offspring exposed to metformin during 
      intrauterine and intrauterine/lactational periods.
PG  - 1-7
LID - S0890-6238(19)30013-9 [pii]
LID - 10.1016/j.reprotox.2019.04.009 [doi]
AB  - Metformin (MET) is a widely-used drug for the treatment of type 2 diabetes 
      mellitus and gestational diabetes. It is known that metformin crosses the 
      placenta and can to be transferred through milk. In vitro studies show that MET 
      decreases gonadotropin-releasing hormone and gonadotropins release in rat 
      neurons, and decreases progesterone and estradiol in rat granulosa cells and 
      androstenedione synthesis in human theca cells. This study evaluated whether MET 
      maternal exposure might interfere with reproductive parameters of female 
      offspring. Wistar female rats were treated with MET 293 mg/kg/day, by gavage, 
      from gestational day (GD) 0 to GD 21 (METG) or GD 0 until lactation day (LD) 21 
      (METGL). Controls groups received water. An increase in plasmatic estradiol 
      levels was observed during the estrus stage in the METGL group. This result 
      suggests that exposure to MET during gestational and lactational periods might be 
      related to programming in theca and/or granulosa cells during development.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Forcato, Simone
AU  - Forcato S
AD  - Department of Physiological Sciences, Center of Biological Sciences, Londrina 
      State University, Londrina, PR, Brazil.
FAU - Montagnini, Bruno Garcia
AU  - Montagnini BG
AD  - Department of Physiological Sciences, Center of Biological Sciences, Londrina 
      State University, Londrina, PR, Brazil.
FAU - de Goes, Maria Luiza Marino
AU  - de Goes MLM
AD  - Department of Physiological Sciences, Center of Biological Sciences, Londrina 
      State University, Londrina, PR, Brazil.
FAU - da Silva Novi, Daniella Regina Barrionuevo
AU  - da Silva Novi DRB
AD  - Department of Physiological Sciences, Center of Biological Sciences, Londrina 
      State University, Londrina, PR, Brazil.
FAU - Inhasz Kiss, Ana Carolina
AU  - Inhasz Kiss AC
AD  - Department of Physiology, Sao Paulo State University, Botucatu, SP, Brazil.
FAU - Ceravolo, Graziela Scalianti
AU  - Ceravolo GS
AD  - Department of Physiological Sciences, Center of Biological Sciences, Londrina 
      State University, Londrina, PR, Brazil.
FAU - Ceccatto Gerardin, Daniela Cristina
AU  - Ceccatto Gerardin DC
AD  - Department of Physiological Sciences, Center of Biological Sciences, Londrina 
      State University, Londrina, PR, Brazil. Electronic address: dcgerardin@uel.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190502
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Hypoglycemic Agents)
RN  - 4TI98Z838E (Estradiol)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Estradiol/blood
MH  - Estrous Cycle/drug effects
MH  - Female
MH  - Fertility/drug effects
MH  - Hypoglycemic Agents/*toxicity
MH  - Lactation
MH  - Maternal Behavior/drug effects
MH  - *Maternal-Fetal Exchange
MH  - Metformin/*toxicity
MH  - Ovary/drug effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats, Wistar
MH  - Sexual Maturation/drug effects
MH  - Uterus/drug effects
OTO - NOTNLM
OT  - Antidiabetic drug
OT  - Estrous cycle
OT  - Maternal exposure
EDAT- 2019/05/06 06:00
MHDA- 2020/03/14 06:00
CRDT- 2019/05/06 06:00
PHST- 2019/01/17 00:00 [received]
PHST- 2019/04/26 00:00 [revised]
PHST- 2019/04/30 00:00 [accepted]
PHST- 2019/05/06 06:00 [pubmed]
PHST- 2020/03/14 06:00 [medline]
PHST- 2019/05/06 06:00 [entrez]
AID - S0890-6238(19)30013-9 [pii]
AID - 10.1016/j.reprotox.2019.04.009 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2019 Aug;87:1-7. doi: 10.1016/j.reprotox.2019.04.009. Epub 2019 
      May 2.