PMID- 31056265
OWN - NLM
STAT- MEDLINE
DCOM- 20200706
LR  - 20200706
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 514
IP  - 2
DP  - 2019 Jun 25
TI  - Aminopeptidase N expression in the endometrium could affect endometrial 
      receptivity.
PG  - 469-474
LID - S0006-291X(19)30831-9 [pii]
LID - 10.1016/j.bbrc.2019.04.174 [doi]
AB  - Aminopeptidase N (ANPEP) is a membrane-bound zinc-dependent peptidase. Although 
      it is widely believed that ANPEP acts as an important angiogenesis regulatory 
      factor, there are few studies about its function in the female reproductive 
      system. In our previous research, we applied Isobaric Tags for Relative and 
      Absolute Quantitation (iTRAQ) to analyze the influence of different controlled 
      superovulation treatments for Assisted Reproductive Technology, In Vitro 
      Fertilization and Embryo Transfer (IVF-ET)) patients from a global proteomic 
      perspective to search for potential biomarkers associated with endometrium 
      receptivity and embryo implantation. ANPEP is one of the proteins that 
      demonstrated differential expression between different treatment groups and may 
      be closely associated with endometrial receptivity. In this study, we assessed 
      the expression of ANPEP in the endometrium of mice at different ages and found it 
      to be highest in the mature period. We also detected ANPEP expression in the 
      endometrium of IVF-ET patients in the proliferative, preimplantation and 
      implantation stages, and the highest expression level of ANPEP was found in the 
      last group. Human primary endometrial stromal cells were infected with an 
      adenovirus expression vector containing the ANPEP gene and a green fluorescent 
      protein (GFP) fusion protein; the mRNA levels of HOXA-10, LIF, and integrin beta3 
      were found to be increased. Therefore, we conclude that ANPEP could be involved 
      in the regulation of endometrial receptivity.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Shui, Li-Jun
AU  - Shui LJ
AD  - State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive 
      Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 
      China; Clinical Center of Reproductive Medicine, The First Affiliated Hospital of 
      USTC, Division of Life Science and Medicine, University of Science and Technology 
      of China, Hefei, China.
FAU - Meng, Yan
AU  - Meng Y
AD  - State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive 
      Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 
      China.
FAU - Huang, Cun
AU  - Huang C
AD  - Clinical Center of Reproductive Medicine, Ma'anshan Maternal and Child Health 
      Hospital, Ma'anshan, China.
FAU - Qian, Yi
AU  - Qian Y
AD  - State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive 
      Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 
      China. Electronic address: qianyi9118@126.com.
FAU - Liu, Jia-Yin
AU  - Liu JY
AD  - State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive 
      Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 
      China. Electronic address: jyliu@njmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190502
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - EC 3.4.11.2 (CD13 Antigens)
SB  - IM
MH  - Adenoviridae/physiology
MH  - Aging
MH  - Animals
MH  - Blastocyst/cytology/metabolism
MH  - CD13 Antigens/*metabolism
MH  - Endometrium/cytology/*enzymology/*physiology
MH  - Female
MH  - *Gene Expression Regulation, Enzymologic
MH  - Humans
MH  - Mice
MH  - Reproduction/*physiology
MH  - Stromal Cells/cytology/enzymology
MH  - Up-Regulation
OTO - NOTNLM
OT  - Adenovirus infection
OT  - Aminopeptidase N
OT  - Endometrial receptivity
OT  - Endometrial receptivity factor
EDAT- 2019/05/06 06:00
MHDA- 2020/07/07 06:00
CRDT- 2019/05/07 06:00
PHST- 2019/04/15 00:00 [received]
PHST- 2019/04/25 00:00 [accepted]
PHST- 2019/05/06 06:00 [pubmed]
PHST- 2020/07/07 06:00 [medline]
PHST- 2019/05/07 06:00 [entrez]
AID - S0006-291X(19)30831-9 [pii]
AID - 10.1016/j.bbrc.2019.04.174 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2019 Jun 25;514(2):469-474. doi: 
      10.1016/j.bbrc.2019.04.174. Epub 2019 May 2.