PMID- 31056368 OWN - NLM STAT- MEDLINE DCOM- 20200723 LR - 20200723 IS - 1879-0828 (Electronic) IS - 0953-6205 (Linking) VI - 64 DP - 2019 Jun TI - Predictive value of serum myostatin for the severity and clinical outcome of heart failure. PG - 33-40 LID - S0953-6205(19)30123-2 [pii] LID - 10.1016/j.ejim.2019.04.017 [doi] AB - BACKGROUND: The exact relationship between serum myostatin and the severity and prognosis of chronic heart failure (CHF) is unclear. In this study, we investigated the association between serum myostatin and the severity and prognosis in patients with CHF. METHODS: Two hundred and eighty-eight CHF patients and 62 healthy controls were studied. Cardiac ultrasound and serum myostatin, N-terminal pro-B-type natriuretic peptide (NT-proBNP) and other parameters were detected. CHF patients were divided into 3 groups according to tertiles of NT-proBNP or myostatin levels respectively. RESULTS: Serum myostatin levels were higher in CHF patients than in controls. New York Heart Association (NYHA) class IV patients had the highest levels of serum myostatin among the four NYHA classes. Compared with the low tertile NT-proBNP group, serum myostatin levels were significantly higher in the moderate and high tertile groups (15.47 +/- 4.25 vs. 14.18 +/- 3.69 ng/mL, p = .026; 16.28 +/- 5.34 vs. 14.18 +/- 3.69 ng/mL, p = .002). During 51-months follow-up, of 173 patients there were 36 deaths. Compared to survivors, nonsurvivors had significantly higher serum myostatin (18.11 +/- 4.52 vs. 14.85 +/- 5.11 ng/mL, p < .01). Patients in the high tertile myostatin group had lower survival rate (73.95% vs. 93.75%; p < .05) and larger number of CHF rehospitalization than those in the low tertile group. Cox regression analysis showed that serum myostatin was an independent predictor of mortality. CONCLUSIONS: Serum myostatin levels can reflect the severity of CHF and be a predictor of adverse prognosis in CHF patients. CI - Copyright (c) 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. FAU - Chen, Pingan AU - Chen P AD - Department of Cardiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China; Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China. Electronic address: cpadejxyx@gzhmu.edu.cn. FAU - Liu, Zhen AU - Liu Z AD - Department of Cardiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China; Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Luo, Yishan AU - Luo Y AD - Department of Cardiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China; Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Chen, Lushan AU - Chen L AD - Department of Cardiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China; Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Li, Shaonan AU - Li S AD - Department of Cardiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China; Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Pan, Yizhi AU - Pan Y AD - Department of Cardiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China; Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Lei, Xiaoming AU - Lei X AD - Department of Cardiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China; Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Wu, Daihong AU - Wu D AD - Ultrasonic Department, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. FAU - Xu, Dingli AU - Xu D AD - State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Key Laboratory for Organ Failure Research, Ministry of Education of the People's Republic of China, Guangzhou, China. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20190502 PL - Netherlands TA - Eur J Intern Med JT - European journal of internal medicine JID - 9003220 RN - 0 (Myostatin) RN - 0 (Peptide Fragments) RN - 0 (pro-brain natriuretic peptide (1-76)) RN - 114471-18-0 (Natriuretic Peptide, Brain) SB - IM MH - Aged MH - Aged, 80 and over MH - Case-Control Studies MH - China MH - Chronic Disease MH - Echocardiography MH - Female MH - Heart Failure/blood/*mortality MH - Humans MH - Male MH - Middle Aged MH - Multivariate Analysis MH - Myostatin/*blood MH - Natriuretic Peptide, Brain/*blood MH - Peptide Fragments/*blood MH - Predictive Value of Tests MH - Prognosis MH - Proportional Hazards Models MH - Survival Rate OTO - NOTNLM OT - Heart failure OT - Myostatin OT - Prognosis EDAT- 2019/05/06 06:00 MHDA- 2020/07/24 06:00 CRDT- 2019/05/07 06:00 PHST- 2018/10/30 00:00 [received] PHST- 2019/04/01 00:00 [revised] PHST- 2019/04/24 00:00 [accepted] PHST- 2019/05/06 06:00 [pubmed] PHST- 2020/07/24 06:00 [medline] PHST- 2019/05/07 06:00 [entrez] AID - S0953-6205(19)30123-2 [pii] AID - 10.1016/j.ejim.2019.04.017 [doi] PST - ppublish SO - Eur J Intern Med. 2019 Jun;64:33-40. doi: 10.1016/j.ejim.2019.04.017. Epub 2019 May 2.