PMID- 31056812 OWN - NLM STAT- MEDLINE DCOM- 20200430 LR - 20200430 IS - 1098-2396 (Electronic) IS - 0887-4476 (Linking) VI - 73 IP - 8 DP - 2019 Aug TI - Can the effects of environmental enrichment modulate BDNF expression in hippocampal plasticity? A systematic review of animal studies. PG - e22103 LID - 10.1002/syn.22103 [doi] AB - BACKGROUND AND AIM: Environmental enrichment (EE) can be related to changes in the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of adult rodents. Exposure to EE may also induce neurogenesis in the dentate gyrus (DG). The aim of this systematic review was to analyze the current literature on the correlation between neurogenesis and BDNF expression in the hippocampal DG region resulting from exposure to EE, which is associated with changes in memory, in rodents. METHODS: Bibliographic searches of the Medline/PubMed and ScienceDirect databases were carried out, and 334 studies were found. A predefined protocol was used and registered on PROSPERO, and 32 studies were included for qualitative synthesis. The PRISMA was used to report this systematic review. RESULTS: Most of the included studies showed that there is little evidence in the literature demonstrating that memory changes resulting from EE are dependent on BDNF expression and that there is an induction of neurogenesis in the hippocampal DG. However, the observed increase in molecular expression levels and cell proliferation is dependent on the age, the timing and duration of exposure to EE. Regarding the methodological quality of the studies, the majority presented a risk of bias due to the high variability in the age of the animals. CONCLUSION: There are few studies in the literature that correlate the molecular and cellular mechanisms involved in neurogenesis in the hippocampal DG with BDNF expression in this region in rodents exposed to EE; however, there are other factors that can modulate this neurogenesis. CI - (c) 2019 Wiley Periodicals, Inc. FAU - Barros, Waleska AU - Barros W AUID- ORCID: 0000-0002-9033-8165 AD - Programa de Pos-Graduacao em Neuropsiquiatria e Ciencias do Comportamento, Universidade Federal de Pernambuco (UFPE), Recife, Brazil. AD - CITENC (Centro integrado de tecnologia em neurociencia), Centro Integrado de Tecnologia e Pesquisa (CINTEP) - Centro Universitario Osman Lins (FACOL), Vitoria de Santo Antao, Brazil. FAU - David, Mirian AU - David M AUID- ORCID: 0000-0002-7152-8852 AD - Programa de Pos-Graduacao em Neuropsiquiatria e Ciencias do Comportamento, Universidade Federal de Pernambuco (UFPE), Recife, Brazil. FAU - Souza, Ana AU - Souza A AUID- ORCID: 0000-0002-3144-2616 AD - Fisioterapia, Centro Universitario Osman Lins (FACOL), Vitoria de Santo Antao, Brazil. FAU - Silva, Mariluce AU - Silva M AUID- ORCID: 0000-0003-4352-7120 AD - Fisioterapia, Centro Universitario Osman Lins (FACOL), Vitoria de Santo Antao, Brazil. FAU - Matos, Rhowena AU - Matos R AUID- ORCID: 0000-0001-5914-7304 AD - Programa de Pos-Graduacao em Neuropsiquiatria e Ciencias do Comportamento, Universidade Federal de Pernambuco (UFPE), Recife, Brazil. AD - Nucleo de Educacao Fisica e Ciencias do Esporte, Universidade Federal de Pernambuco Centro Academico de Vitoria (CAV), Vitoria de Santo Antao, Brazil. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20190517 PL - United States TA - Synapse JT - Synapse (New York, N.Y.) JID - 8806914 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/*metabolism MH - *Environment MH - Hippocampus/*physiology MH - Neurogenesis/*physiology MH - Neuronal Plasticity/*physiology OTO - NOTNLM OT - environmental enrichment OT - hippocampus OT - memory OT - neurogenesis EDAT- 2019/05/06 06:00 MHDA- 2020/05/01 06:00 CRDT- 2019/05/07 06:00 PHST- 2019/01/24 00:00 [received] PHST- 2019/04/28 00:00 [revised] PHST- 2019/04/29 00:00 [accepted] PHST- 2019/05/06 06:00 [pubmed] PHST- 2020/05/01 06:00 [medline] PHST- 2019/05/07 06:00 [entrez] AID - 10.1002/syn.22103 [doi] PST - ppublish SO - Synapse. 2019 Aug;73(8):e22103. doi: 10.1002/syn.22103. Epub 2019 May 17.