PMID- 31057114
OWN - NLM
STAT- MEDLINE
DCOM- 20200928
LR  - 20200928
IS  - 1875-6212 (Electronic)
IS  - 1570-1611 (Linking)
VI  - 18
IP  - 2
DP  - 2020
TI  - Microvascular Complications of Type 2 Diabetes Mellitus.
PG  - 117-124
LID - 10.2174/1570161117666190502103733 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic, non communicable, 
      multisystem disease that has reached epidemic proportions. Chronic exposure to 
      hyperglycaemia affects the microvasculature, eventually leading to diabetic 
      nephropathy, retinopathy and neuropathy with high impact on the quality of life 
      and overall life expectancy. Sexual dysfunction is an often-overlooked 
      microvascular complication of T2DM, with a complex pathogenesis originating from 
      endothelial dysfunction. OBJECTIVE: The purpose of this review is to present 
      current definitions, epidemiological data and risk factors for diabetic 
      retinopathy, nephropathy, neuropathy and sexual dysfunction. We also describe the 
      clinical and laboratory evaluation that is mandatory for the diagnosis of these 
      conditions. METHODS: A comprehensive review of the literature was performed to 
      identify data from clinical studies for the prevalence, risk factors and 
      diagnostic methods of microvascular complications of T2DM. RESULTS: Diabetic 
      nephropathy and retinopathy affect approximately 25% of patients with T2DM; 
      diabetic neuropathy is encountered in almost 50% of the diabetic population, 
      while the prevalence of erectile dysfunction ranges from 35-90% in diabetic men. 
      The duration of T2DM along with glycemic, blood pressure and lipid control are 
      common risk factors for the development of these complications. Criteria for the 
      diagnosis of these conditions are well established, but exclusion of other causes 
      is mandatory. CONCLUSION: Early detection of microvascular complications 
      associated with T2DM is important, as early intervention leads to better 
      outcomes. However, this requires awareness of their definition, prevalence and 
      diagnostic modalities.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Faselis, Charles
AU  - Faselis C
AD  - VA Medical Center, Washington, D.C., United States.
FAU - Katsimardou, Alexandra
AU  - Katsimardou A
AD  - 2nd Prop Department of Internal Medicine, Aristotle University, Thessaloniki, 
      Greece.
FAU - Imprialos, Konstantinos
AU  - Imprialos K
AD  - 2nd Prop Department of Internal Medicine, Aristotle University, Thessaloniki, 
      Greece.
FAU - Deligkaris, Pavlos
AU  - Deligkaris P
AD  - Department of Neurology, Hippokrateion Hospital, Thessaloniki, Greece.
FAU - Kallistratos, Manolis
AU  - Kallistratos M
AD  - Cardiology Department, Asklepeion Hospital, Athens, Greece.
FAU - Dimitriadis, Kiriakos
AU  - Dimitriadis K
AD  - 1st Department of Cardiology, University of Athens, Athens, Greece.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Vasc Pharmacol
JT  - Current vascular pharmacology
JID - 101157208
SB  - IM
MH  - Diabetes Mellitus, Type 2/diagnosis/*epidemiology/physiopathology
MH  - Diabetic Angiopathies/diagnosis/*epidemiology/physiopathology
MH  - Diabetic Nephropathies/diagnosis/*epidemiology/physiopathology
MH  - Diabetic Neuropathies/diagnosis/*epidemiology/physiopathology
MH  - Diabetic Retinopathy/epidemiology/physiopathology
MH  - Early Diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Prevalence
MH  - Prognosis
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sexual Dysfunction, Physiological/diagnosis/*epidemiology/physiopathology
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - diabetic kidney disease
OT  - diabetic neuropathy
OT  - diabetic retinopathy
OT  - erectile dysfunction
OT  - microvascular complications.
EDAT- 2019/05/07 06:00
MHDA- 2020/09/29 06:00
CRDT- 2019/05/07 06:00
PHST- 2018/10/18 00:00 [received]
PHST- 2018/11/06 00:00 [revised]
PHST- 2018/11/12 00:00 [accepted]
PHST- 2019/05/07 06:00 [pubmed]
PHST- 2020/09/29 06:00 [medline]
PHST- 2019/05/07 06:00 [entrez]
AID - CVP-EPUB-98322 [pii]
AID - 10.2174/1570161117666190502103733 [doi]
PST - ppublish
SO  - Curr Vasc Pharmacol. 2020;18(2):117-124. doi: 10.2174/1570161117666190502103733.