PMID- 31057366
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1662-5099 (Print)
IS  - 1662-5099 (Electronic)
IS  - 1662-5099 (Linking)
VI  - 12
DP  - 2019
TI  - Relevance of ERK1/2 Post-retrieval Participation on Memory Processes: Insights in 
      Their Particular Role on Reconsolidation and Persistence of Memories.
PG  - 95
LID - 10.3389/fnmol.2019.00095 [doi]
LID - 95
AB  - Back in 1968, Misanin and his group posited that reactivation of consolidated 
      memories could support changes in that trace, similar to what might happen during 
      the consolidation process. Not until 2000, when Nader et al. (2000) studied the 
      behavioral effect of a protein synthesis inhibitor on retrieved memories, could 
      this previous statement be taken under consideration once again; suggesting that 
      consolidated memories can become labile after reactivation. The process of 
      strengthening after memory labilization was named memory reconsolidation. In 
      recent years, many studies pointed towards a critical participation of the 
      extracellular signal-regulated kinase (ERK)/mitogen activated protein kinases 
      (MAPKs) pathway in different memory processes (e.g., consolidation, extinction, 
      reconsolidation, among others). In this review article, we will focus on how this 
      system might be modulating the processes triggered after retrieval of 
      well-consolidated memories in mice.
FAU - Krawczyk, Maria C
AU  - Krawczyk MC
AD  - Laboratorio de Neurofarmacologia de los Procesos de Memoria, Catedra de 
      Farmacologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires 
      (UBA), Buenos Aires, Argentina.
FAU - Millan, Julieta
AU  - Millan J
AD  - Laboratorio de Neurofarmacologia de los Procesos de Memoria, Catedra de 
      Farmacologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires 
      (UBA), Buenos Aires, Argentina.
FAU - Blake, Mariano G
AU  - Blake MG
AD  - Instituto de Fisiologia y Biofisica (IFIBIO UBA-CONICET), Facultad de Medicina, 
      Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.
FAU - Feld, Mariana
AU  - Feld M
AD  - CONICET-Universidad de Buenos Aires, Instituto de Fisiologia, Biologia Molecular 
      y Neurociencias (IFIBYNE), CABA, Argentina.
FAU - Boccia, Mariano M
AU  - Boccia MM
AD  - Laboratorio de Neurofarmacologia de los Procesos de Memoria, Catedra de 
      Farmacologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires 
      (UBA), Buenos Aires, Argentina.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190417
PL  - Switzerland
TA  - Front Mol Neurosci
JT  - Frontiers in molecular neuroscience
JID - 101477914
PMC - PMC6478671
OTO - NOTNLM
OT  - ERK/MAPK
OT  - PD098059
OT  - inhibitory avoidance
OT  - memory persistence
OT  - memory reconsolidation
OT  - mice
EDAT- 2019/05/07 06:00
MHDA- 2019/05/07 06:01
PMCR- 2019/01/01
CRDT- 2019/05/07 06:00
PHST- 2018/10/15 00:00 [received]
PHST- 2019/03/29 00:00 [accepted]
PHST- 2019/05/07 06:00 [entrez]
PHST- 2019/05/07 06:00 [pubmed]
PHST- 2019/05/07 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fnmol.2019.00095 [doi]
PST - epublish
SO  - Front Mol Neurosci. 2019 Apr 17;12:95. doi: 10.3389/fnmol.2019.00095. eCollection 
      2019.