PMID- 31057473 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 1664-2295 (Print) IS - 1664-2295 (Electronic) IS - 1664-2295 (Linking) VI - 10 DP - 2019 TI - Impulse Control Disorders in Parkinson's Disease. A Brief and Comprehensive Review. PG - 351 LID - 10.3389/fneur.2019.00351 [doi] LID - 351 AB - Impulse control and related disorders (ICDs-RD) encompasses a heterogeneous group of disorders that involve pleasurable behaviors performed repetitively, excessively, and compulsively. The key common symptom in all these disorders is the failure to resist an impulse or temptation to control an act or specific behavior, which is ultimately harmful to oneself or others and interferes in major areas of life. The major symptoms of ICDs include pathological gambling (PG), hypersexualtiy (HS), compulsive buying/shopping (CB) and binge eating (BE) functioning. ICDs and ICDs-RD have been included in the behavioral spectrum of non-motor symptoms in Parkinson's disease (PD) leading, in some cases, to serious financial, legal and psychosocial devastating consequences. Herein we present the prevalence of ICDs, the risk factors, its pathophysiological mechanisms, the link with agonist dopaminergic therapies and therapeutic managements. FAU - Gatto, Emilia M AU - Gatto EM AD - Department of Neurology, Sanatorio de la Trinidad Mitre, Buenos Aires, Argentina. AD - Instituto de Neurociencias Buenos Aires, Ineba, Buenos Aires, Argentina. FAU - Aldinio, Victoria AU - Aldinio V AD - Department of Neurology, Sanatorio de la Trinidad Mitre, Buenos Aires, Argentina. LA - eng PT - Journal Article DEP - 20190417 PL - Switzerland TA - Front Neurol JT - Frontiers in neurology JID - 101546899 PMC - PMC6481351 OTO - NOTNLM OT - ICD OT - Parkinson disease OT - binge eating OT - compulsive buying OT - hypersexual disorder OT - impulse control disorders OT - pathological gambling EDAT- 2019/05/07 06:00 MHDA- 2019/05/07 06:01 PMCR- 2019/04/17 CRDT- 2019/05/07 06:00 PHST- 2018/08/02 00:00 [received] PHST- 2019/03/22 00:00 [accepted] PHST- 2019/05/07 06:00 [entrez] PHST- 2019/05/07 06:00 [pubmed] PHST- 2019/05/07 06:01 [medline] PHST- 2019/04/17 00:00 [pmc-release] AID - 10.3389/fneur.2019.00351 [doi] PST - epublish SO - Front Neurol. 2019 Apr 17;10:351. doi: 10.3389/fneur.2019.00351. eCollection 2019.