PMID- 31057987
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2155-9562 (Print)
IS  - 2155-9562 (Electronic)
VI  - 10
IP  - 1
DP  - 2019
TI  - Assessing Retinal Structure in Patients with Parkinson's Disease.
LID - 485 [pii]
LID - 10.4172/2155-9562.1000485 [doi]
AB  - OBJECTIVE: The retina is an extension of the central nervous system (CNS), and 
      ocular symptoms can precede manifestations of CNS disorders. Given that several 
      neurodegenerative conditions that affect the brain exhibit ocular symptoms, the 
      retina may be an accessible biomarker to monitor disease progression. Dopamine, 
      the key neurotransmitter related to Parkinson's disease (PD), is contained in 
      amacrine and interplexiform cells, which reside in specific retinal layers. 
      Understanding how loss of dopaminergic cells affects retinal anatomy could be 
      relevant for monitoring disease progression. Here, our objective is to evaluate 
      retinal structure (foveal pit morphology and thickness) in patients with PD. 
      METHODS: Thirty-three Caucasian subjects diagnosed with PD and 40 age-matched 
      Caucasian control subjects underwent retinal imaging with spectral-domain optical 
      coherence tomography (SD-OCT). Axial length measurements were used to correct the 
      lateral scale of each macular volume scan. From these corrected volumes, foveal 
      morphology was quantified with previously described algorithms, and Early 
      Treatment Diabetic Retinopathy Study (ETDRS) grids of retinal thickness were 
      generated and incorporated into a logistic regression model to predict PD. 
      RESULTS: Interocular foveal morphology measurements were highly symmetrical in PD 
      patients and control subjects. There were no significant differences in foveal 
      pit morphology between PD patients and control subjects. Using a model 
      incorporating sex and axial length corrected ETDRS regions, we generated a 
      receiver operating characteristic curve with a C-statistic of 0.80. CONCLUSION: 
      Our study, which to our knowledge is the first to properly scale OCT measurements 
      when quantifying retinal thickness, demonstrates that PD patients retain foveal 
      symmetry between eyes. When constructing a model to predict PD, sex, along with 
      the center 1 mm and temporal outer ETDRS regions, were significant predictors of 
      PD. In addition to proper scaling of OCT measures, gender and racial differences 
      in retinal anatomy should be considered in building future predictive PD models 
      when using OCT.
FAU - Young, Jonathon B
AU  - Young JB
AD  - Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, 
      Milwaukee, USA.
FAU - Godara, Pooja
AU  - Godara P
AD  - Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, 
      Milwaukee, USA.
FAU - Williams, Vesper
AU  - Williams V
AD  - Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, 
      Milwaukee, USA.
FAU - Summerfelt, Phyllis
AU  - Summerfelt P
AD  - Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, 
      Milwaukee, USA.
FAU - Connor, Thomas B
AU  - Connor TB
AD  - Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, 
      Milwaukee, USA.
FAU - Tarima, Sergey
AU  - Tarima S
AD  - Division of Biostatistics, Institute for Health and Equity, Medical College of 
      Wisconsin, USA.
FAU - Visotcky, Alexis
AU  - Visotcky A
AD  - Division of Biostatistics, Institute for Health and Equity, Medical College of 
      Wisconsin, USA.
FAU - Cooper, Robert F
AU  - Cooper RF
AD  - Department of Biomedical Engineering, Marquette University, Milwaukee, USA.
FAU - Blindauer, Karen
AU  - Blindauer K
AD  - Department of Neurology, Medical College of Wisconsin, USA.
FAU - Carroll, Joseph
AU  - Carroll J
AD  - Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, 
      Milwaukee, USA.
AD  - Department of Biomedical Engineering, Marquette University, Milwaukee, USA.
AD  - Department of Cell Biology, Neurobiology and Anatomy, Medical College of 
      Wisconsin, USA.
LA  - eng
GR  - C06 RR016511/RR/NCRR NIH HHS/United States
GR  - P30 EY001931/EY/NEI NIH HHS/United States
GR  - R01 EY017607/EY/NEI NIH HHS/United States
GR  - UL1 TR001436/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20190307
PL  - United States
TA  - J Neurol Neurophysiol
JT  - Journal of neurology & neurophysiology
JID - 101569484
PMC - PMC6494090
MID - NIHMS1017407
OTO - NOTNLM
OT  - Fovea
OT  - Optical coherence tomography
OT  - Parkinson's disease
OT  - Retina
EDAT- 2019/05/07 06:00
MHDA- 2019/05/07 06:01
PMCR- 2019/05/01
CRDT- 2019/05/07 06:00
PHST- 2019/05/07 06:00 [entrez]
PHST- 2019/05/07 06:00 [pubmed]
PHST- 2019/05/07 06:01 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - 485 [pii]
AID - 10.4172/2155-9562.1000485 [doi]
PST - ppublish
SO  - J Neurol Neurophysiol. 2019;10(1):485. doi: 10.4172/2155-9562.1000485. Epub 2019 
      Mar 7.