PMID- 31058895
OWN - NLM
STAT- MEDLINE
DCOM- 20200324
LR  - 20200419
IS  - 1940-087X (Electronic)
IS  - 1940-087X (Linking)
IP  - 146
DP  - 2019 Apr 19
TI  - The Power of Interstimulus Interval for the Assessment of Temporal Processing in 
      Rodents.
LID - 10.3791/58659 [doi]
AB  - Temporal processing deficits have been implicated as a potential elemental 
      dimension of higher-level cognitive processes, commonly observed in 
      neurocognitive disorders. Despite the popularization of prepulse inhibition (PPI) 
      in recent years, many current protocols promote using a percent of control 
      measure, thereby precluding the assessment of temporal processing. The present 
      study used cross-modal PPI and gap prepulse inhibition (gap-PPI) to demonstrate 
      the benefits of employing a range of interstimulus intervals (ISIs) to delineate 
      effects of sensory modality, psychostimulant exposure, and age. Assessment of 
      sensory modality, psychostimulant exposure, and age reveals the utility of an 
      approach varying the interstimulus interval (ISI) to establish the shape of the 
      ISI function, including increases (sharper curve inflections) or decreases 
      (flattening of the response amplitude curve) in startle amplitude. Additionally, 
      shifts in peak response inhibition, suggestive of a differential sensitivity to 
      the manipulation of ISI, are often revealed. Thus, the systematic manipulation of 
      ISI affords a critical opportunity to evaluate temporal processing, which may 
      reveal the underlying neural mechanisms involved in neurocognitive disorders.
FAU - McLaurin, Kristen A
AU  - McLaurin KA
AD  - Program in Behavioral Neuroscience, Department of Psychology, University of South 
      Carolina.
FAU - Moran, Landhing M
AU  - Moran LM
AD  - Program in Behavioral Neuroscience, Department of Psychology, University of South 
      Carolina.
FAU - Li, Hailong
AU  - Li H
AD  - Program in Behavioral Neuroscience, Department of Psychology, University of South 
      Carolina.
FAU - Booze, Rosemarie M
AU  - Booze RM
AD  - Program in Behavioral Neuroscience, Department of Psychology, University of South 
      Carolina.
FAU - Mactutus, Charles F
AU  - Mactutus CF
AD  - Program in Behavioral Neuroscience, Department of Psychology, University of South 
      Carolina; mactutus@mailbox.sc.edu.
LA  - eng
GR  - R01 DA013137/DA/NIDA NIH HHS/United States
GR  - R01 HD043680/HD/NICHD NIH HHS/United States
GR  - R01 MH106392/MH/NIMH NIH HHS/United States
GR  - R01 NS100624/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Video-Audio Media
DEP - 20190419
PL  - United States
TA  - J Vis Exp
JT  - Journal of visualized experiments : JoVE
JID - 101313252
SB  - IM
MH  - *Acoustic Stimulation/methods
MH  - Age Factors
MH  - Animals
MH  - Female
MH  - Male
MH  - Mental Processes
MH  - *Prepulse Inhibition
MH  - Rats
PMC - PMC6702946
MID - NIHMS1030218
COIS- Disclosures None of the authors have conflicts of interest to declare.
EDAT- 2019/05/07 06:00
MHDA- 2020/03/25 06:00
PMCR- 2020/04/19
CRDT- 2019/05/07 06:00
PHST- 2019/05/07 06:00 [entrez]
PHST- 2019/05/07 06:00 [pubmed]
PHST- 2020/03/25 06:00 [medline]
PHST- 2020/04/19 00:00 [pmc-release]
AID - 10.3791/58659 [doi]
PST - epublish
SO  - J Vis Exp. 2019 Apr 19;(146):10.3791/58659. doi: 10.3791/58659.