PMID- 31058998
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230412
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 104
IP  - 9
DP  - 2019 Sep 1
TI  - Cardiorespiratory Fitness Does Not Offset Adiposity-Related Systemic Inflammation 
      in Physically Active Older Women.
PG  - 4119-4126
LID - 10.1210/jc.2019-00067 [doi]
AB  - CONTEXT: Chronic inflammation increases diabetes risk and may be exacerbated by 
      excess adipose tissue. Whether cardiovascular fitness can offset chronic 
      inflammation associated with excess adipose tissue in older adults is unclear. 
      OBJECTIVE: The study aimed to examine the influence of cardiorespiratory fitness 
      on links between adiposity and pro- and anti-inflammatory biomarkers related to 
      metabolic risk in physically active older women. DESIGN, SETTING, AND 
      PARTICIPANTS: Cross-sectional study comprising older community-dwelling women (n 
      = 109; age, 65 to 70 years). MAIN OUTCOME: Cardiorespiratory fitness was assessed 
      using a standardized submaximal test and participants were categorized into high- 
      and low-adiposity-related metabolic risk [body mass index, waist-to-hip ratio 
      (WHR), and total fat mass]. The inflammatory biomarkers C-reactive protein (CRP), 
      IL-6, IL-10, IL-18, adiponectin, monocyte chemoattractant protein-1 (MCP-1), and 
      macrophage inflammatory protein (MIP)-1alpha were analyzed. RESULTS: Regardless of 
      adiposity measure, women in the metabolic high-risk group had substantially 
      elevated (P < 0.05) CRP and lower adiponectin levels. Levels of IL-6 and MIP1-alpha 
      were elevated in the high-risk group defined by WHR and total fat mass. The IL-18 
      level was elevated in the high-risk group based on WHR only. Importantly, a high 
      cardiorespiratory fitness level did not attenuate the detrimental links between 
      adiposity measures and inflammation. CONCLUSIONS: Cardiorespiratory fitness does 
      not offset the detrimental links between adiposity and several inflammatory 
      biomarkers related to metabolic risk in physically active older women. Reducing 
      abdominal adipose tissue in older adults should be emphasized in efforts aiming 
      to attenuate age-related systemic inflammation and metabolic risk regardless of 
      cardiorespiratory fitness.
CI  - Copyright (c) 2019 Endocrine Society.
FAU - Bergens, Oscar
AU  - Bergens O
AD  - School of Health Sciences, Orebro University, Orebro, Sweden.
FAU - Nilsson, Andreas
AU  - Nilsson A
AD  - School of Health Sciences, Orebro University, Orebro, Sweden.
FAU - Kadi, Fawzi
AU  - Kadi F
AUID- ORCID: 0000-0002-9831-0896
AD  - School of Health Sciences, Orebro University, Orebro, Sweden.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
SB  - IM
EDAT- 2019/05/07 06:00
MHDA- 2019/05/07 06:01
CRDT- 2019/05/07 06:00
PHST- 2019/01/09 00:00 [received]
PHST- 2019/04/30 00:00 [accepted]
PHST- 2019/05/07 06:01 [medline]
PHST- 2019/05/07 06:00 [pubmed]
PHST- 2019/05/07 06:00 [entrez]
AID - 5485086 [pii]
AID - 10.1210/jc.2019-00067 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2019 Sep 1;104(9):4119-4126. doi: 10.1210/jc.2019-00067.