PMID- 31059136
OWN - NLM
STAT- MEDLINE
DCOM- 20210106
LR  - 20210109
IS  - 1469-8986 (Electronic)
IS  - 0048-5772 (Print)
IS  - 0048-5772 (Linking)
VI  - 57
IP  - 1
DP  - 2020 Jan
TI  - Experiencing community and domestic violence is associated with epigenetic 
      changes in DNA methylation of BDNF and CLPX in adolescents.
PG  - e13382
LID - 10.1111/psyp.13382 [doi]
LID - e13382
AB  - Experiencing violence changes behavior, shapes personalities, and poses a risk 
      factor for mental disorders. This association might be mediated through 
      epigenetic modifications that affect gene expression, such as DNA methylation. 
      The present study investigated the impact of community and domestic violence on 
      DNA methylation measured in saliva collected from 375 individuals including three 
      generations: grandmothers (n = 126), mothers (n = 125), and adolescents (n = 124, 
      53% female). Using the Infinium HumanMethylation450 BeadChip array, in 
      adolescents, we detected two CpG sites that showed an association of DNA 
      methylation and lifetime exposure to community and domestic violence even after 
      FDR correction: BDNF_cg06260077 (logFC -0.454, p = 3.71E-07), and CLPX_cg01908660 
      (logFC = -0.372, p = 1.38E-07). Differential DNA methylation of the CpG 
      BDNF_cg06260077 associated with exposure to violence was also observed in the 
      maternal but not the grandmaternal generation. BDNF (brain-derived neurotrophic 
      factor) and CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit) 
      genes are involved in neural development. Our results thus reveal altered 
      molecular mechanisms of developmental and intergenerational trajectories in 
      survivors of repeated violent experiences.
CI  - (c) 2019 The Authors Psychophysiology published by Wiley Periodicals, Inc. on 
      behalf of Society for Psychophysiological Research.
FAU - Serpeloni, Fernanda
AU  - Serpeloni F
AUID- ORCID: 0000-0001-6222-0162
AD  - Clinical Psychology and Neuropsychology, Department of Psychology, University of 
      Konstanz, Konstanz, Germany.
AD  - National School of Public Health of Rio de Janeiro and National Institute of 
      Women, Children and Adolescents' Health Fernandes Figueira, Oswaldo Cruz 
      Foundation, Rio de Janeiro, Brazil.
FAU - Natt, Daniel
AU  - Natt D
AD  - Department of Clinical and Experimental Medicine, Center for Social and Affective 
      Neuroscience, Linkoping University, Linkoping, Sweden.
FAU - Assis, Simone Goncalves de
AU  - Assis SG
AD  - National School of Public Health of Rio de Janeiro and National Institute of 
      Women, Children and Adolescents' Health Fernandes Figueira, Oswaldo Cruz 
      Foundation, Rio de Janeiro, Brazil.
FAU - Wieling, Elizabeth
AU  - Wieling E
AD  - Family Social Science, University of Minnesota, Minneapolis and St. Paul, 
      Minnesota.
FAU - Elbert, Thomas
AU  - Elbert T
AD  - Clinical Psychology and Neuropsychology, Department of Psychology, University of 
      Konstanz, Konstanz, Germany.
LA  - eng
GR  - 323977/ERC_/European Research Council/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190506
PL  - United States
TA  - Psychophysiology
JT  - Psychophysiology
JID - 0142657
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 3.4.21.92 (Endopeptidase Clp)
RN  - EC 3.6.1.3 (CLPX protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - DNA Methylation/*genetics
MH  - *Domestic Violence
MH  - Endopeptidase Clp/*genetics
MH  - Epigenesis, Genetic/*genetics
MH  - *Exposure to Violence
MH  - Female
MH  - Grandparents
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mothers
MH  - Residence Characteristics
MH  - Survivors
MH  - Young Adult
PMC - PMC7003421
OTO - NOTNLM
OT  - BDNF
OT  - DNA methylation
OT  - adolescents
OT  - epigenetics
OT  - intergenerational
OT  - violence
EDAT- 2019/05/07 06:00
MHDA- 2021/01/07 06:00
PMCR- 2020/02/06
CRDT- 2019/05/07 06:00
PHST- 2018/05/30 00:00 [received]
PHST- 2019/04/03 00:00 [revised]
PHST- 2019/04/04 00:00 [accepted]
PHST- 2019/05/07 06:00 [pubmed]
PHST- 2021/01/07 06:00 [medline]
PHST- 2019/05/07 06:00 [entrez]
PHST- 2020/02/06 00:00 [pmc-release]
AID - PSYP13382 [pii]
AID - 10.1111/psyp.13382 [doi]
PST - ppublish
SO  - Psychophysiology. 2020 Jan;57(1):e13382. doi: 10.1111/psyp.13382. Epub 2019 May 
      6.