PMID- 31059702 OWN - NLM STAT- MEDLINE DCOM- 20191211 LR - 20191217 IS - 1873-3492 (Electronic) IS - 0009-8981 (Linking) VI - 495 DP - 2019 Aug TI - Increased plasma sestrin2 concentrations in patients with chronic heart failure and predicted the occurrence of major adverse cardiac events: A 36-month follow-up cohort study. PG - 338-344 LID - S0009-8981(19)31839-X [pii] LID - 10.1016/j.cca.2019.04.084 [doi] AB - BACKGROUND: Previous study had demonstrated that sestrin2 (Sesn2) expression was increased in human failing heart. Although, the circulating Sesn2 concentrations in patients with chronic heart failure (CHF) remains unknown. This study investigated plasma Sesn2 concentrations in patients with CHF and the role between Sesn2 and the occurrence of major adverse cardiac events. METHODS: A total of 80 control subjects and 220 CHF patients were enrolled and the Sesn2 concentrations of each sample were measured. Additionally, the occurrence of major adverse cardiac events in each CHF patient were followed prospectively for 36 months. RESULTS: Increased plasma Sesn2 concentrations were found in CHF patients and gradually increased from New York Heart Association (NYHA) functional class II to IV. The Sesn2 concentrations were positively correlated with N-terminal B-type natriuretic peptide (NT-pro BNP) but negatively correlated with left ventricular ejection fraction (LVEF) in CHF patients. The ROC curve suggested that Sesn2 had a certain value in predicting major adverse cardiac events during CHF patients, although, the predictive role of Sesn2 is not as good as NT-pro BNP. In addition, the multivariate Cox hazard analysis was performed after the CHF patients were divided into 3 groups (low, middle, and high) base on the plasma Sesn2 concentrations category, and the results showed that both high and middle Sesn2 concentrations increased the incidence of major adverse cardiac events when compared with low Sesn2 group. Furthermore, CHF patients with major adverse cardiac events showed higher Sesn2 concentrations when compared with CHF without major adverse cardiac events. The Kaplan-Meier analysis was performed after the CHF patients were divided into 2 groups according to the median Sesn2 concentrations and the results revealed that patients with high Sesn2 concentrations had a higher risk of major adverse cardiac events compared with those with low Sesn2. CONCLUSIONS: Plasma Sesn2 concentrations were increased in CHF patients and positively correlated with the severity of CHF. Increased Sesn2 concentrations significantly increased the occurrence of major adverse cardiac events and suggested poor outcome in CHF patients. CI - Copyright (c) 2019. Published by Elsevier B.V. FAU - Wang, Haixiong AU - Wang H AD - Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, China. FAU - Li, Na AU - Li N AD - Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, China. FAU - Shao, Xin AU - Shao X AD - Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, China. FAU - Li, Jun AU - Li J AD - Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, China. FAU - Guo, Liping AU - Guo L AD - Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, China. FAU - Yu, Xingyan AU - Yu X AD - Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, China. FAU - Sun, Yuehui AU - Sun Y AD - Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, China. FAU - Hao, Jinlin AU - Hao J AD - Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, China. FAU - Niu, Huaimin AU - Niu H AD - Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, China. FAU - Xiang, Jie AU - Xiang J AD - Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, China. FAU - Li, Xiaofang AU - Li X AD - Department of geriatric medicine，Shanxi Dayi Hospital, Taiyuan, Shanxi, China. Electronic address: lxf838428781@163.com. FAU - Han, Xuebin AU - Han X AD - Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, China. Electronic address: hanxuebin669799@163.com. LA - eng PT - Journal Article DEP - 20190503 PL - Netherlands TA - Clin Chim Acta JT - Clinica chimica acta; international journal of clinical chemistry JID - 1302422 RN - 0 (Nuclear Proteins) RN - 0 (Peptide Fragments) RN - 0 (SESN2 protein, human) RN - 0 (pro-brain natriuretic peptide (1-76)) RN - 114471-18-0 (Natriuretic Peptide, Brain) SB - IM MH - Aged MH - Cardiovascular Diseases/*etiology MH - Case-Control Studies MH - Cohort Studies MH - Female MH - Follow-Up Studies MH - Heart Failure/*blood/diagnosis MH - Humans MH - Male MH - Middle Aged MH - Natriuretic Peptide, Brain/blood MH - Nuclear Proteins/*blood MH - Peptide Fragments/blood MH - Predictive Value of Tests MH - Prognosis MH - Stroke Volume OTO - NOTNLM OT - Chronic heart failure OT - Major adverse cardiac events OT - Prognosis OT - Sestrin2 EDAT- 2019/05/07 06:00 MHDA- 2019/12/18 06:00 CRDT- 2019/05/07 06:00 PHST- 2019/03/12 00:00 [received] PHST- 2019/04/10 00:00 [revised] PHST- 2019/04/29 00:00 [accepted] PHST- 2019/05/07 06:00 [pubmed] PHST- 2019/12/18 06:00 [medline] PHST- 2019/05/07 06:00 [entrez] AID - S0009-8981(19)31839-X [pii] AID - 10.1016/j.cca.2019.04.084 [doi] PST - ppublish SO - Clin Chim Acta. 2019 Aug;495:338-344. doi: 10.1016/j.cca.2019.04.084. Epub 2019 May 3.